Medications, supplements and other therapies used in Parkinsons

[healthyheart7]

Here is a partial list of medication, supplements for other therapies used in Parkinsons

What do you believe are the most beneficial/essential to treating Parkinsons and/or mitochondrial damage

Which way should I go?

Most bang for your bucks

Carbadopa/Levadopa

 L-5-hydroxytryptophan (5-HTP)

Actylcholine

Actigal/Ursolic acid

Adderil (amphetamine)

Alcohol

Alpha GBC

Alpha-Ketobutyric acid

Alpha Lipoic Acid

Amantadine

Artemisinin

Ashwagandha

Astragalus

Azilect

Berberine

BioVie

Brain derived neurotropic factor (BDNF)

Black Seed Oil (Nigella Saliva)

BMPS/7

Broccoli Sprout

Butyric acid

B-carotene

Cannabis

CBD

Celastrol

Celebrex

Choline

Cinnamon, Ceylon

Coffee

Coconut Oil

CoEnzyme Q10

Collagen

COMT inhibitors (entacapone, tolcapone)

Caffeine

Cerebral Dopamine Neurotrophic Factor (CDNF)

Cordyceps Mushroom

Creatine

Curcumin/Tumeric

L-Alpha Cysteine

Diet

DA01

Dopamine agonists (pramipexole, ropinirole, rotigotine patch)

Dark Choolate

Doxycycline

Epigallocatechin-3-Gallate (from Green Tea)

Entracapon or istradefylline

Exercise

Estrogen

Fish oil

Flavanoids

GABA

Ginkgo Biloba Extract

Glutathione

GLP-1 (Victoza)

Hydrogen water

Ibuprofen

Infrared light therapy

K2

Kelp

Lactoferrin

Leucitine

Lecithin

Licorice

Luteolin

L-Theanine

Lycopene

Magnesium

Mannitol

MAO-B inhibitors Selegiline, Rasagiline, and Safinamide

Melatonin

MRx0005 and MRx0029

Miraplex

Mitochondrial NRG

Mitochondrial Basics with PQQ Life Extension

Mulberry

N-acetyl cystine

Niacin

Nicotine

Nicotinamide

NuPro

Olive Oil

Omega-3 Fatty Acid

Optimized Yinxieling Formula

Oregano Extract

Oxytocin

Palmogrant

Phosphatidylserine synthase(PEA)

Phenylethylamine

Progesterone

Phoshatidylserine

Prebiotics

Polygala root extract (PRE)

Prednisone

Probiotics

Progesterone

Pueraria Mirifica

Probiotics/Prebiotics

Quercetin (Relaxin)

Quercetin (from pollen)

Red wine

Resevatro

RoseMary

Saw Palmento

Sesame Seed Oil

SGLT2 inhibitor

Shogaol ( Zingiber officinale) Ginger

Spirulina

Telos95

Terazosin/possibly Tamsulosin

Testosterone

Theanine

Thunder Root

Trihexyphenidyl (Artane)

Triptolide

L-Trypophan

Tauoursodeoxycholic acid

Tyrosine

Urothin A/ Urolithin A

Ursolic Acid

Ursodeoxycholic acid

UDCA

Viagra

Vitamin B1

Vitamin B2

Vitamin B6

Vitamin B12

Vitamin C

Vitamin D

Vitamin E

High dose thiamine

Berries

Stem Advanced Support (american Health Limited

Focus Ultrasound

Mito PQQ

Mito_NR

Whole Food Multi-Vitamin

Licorice

Platlet Rich Plasma restores smell and taste in Covid pts

NAC

Glutatione

Caffeine and Eicosanoyl-5-hydroxytryptamide (EHT) may work together

Black tea

Curcumin and tauroursodeoxycholic (TUDCA) 

Principal neuroprotective substances.

Peptides

Glycoproteins

Pigments

Lipids

Glycolipids

Glycosaminoglycans

Polysaccharides

Macrolides

Polycyclic ethers

Guanidine neurotoxins

Indole alkaloids

Marine drugs affecting the CNS.

Beta-secretase 1 inhibitors

Glycogen synthase kinase-3 inhibitors

Cholinesterase inhibitors

Nicotinic acetylcholine receptor antagonists

Glycine receptors modulators

Neuronal growth inducers

[Bolt_Upright]

Vinpocetine regulates levels of circulating TLRs in Parkinson's disease patients 2018 sci-hub.se/10.1007/s10072-0...

I get 30 mg capsules from Swanson and take one a day with food.

Per this article: nootropicsexpert.com/vinpoc...

Vinpocetine helps:

• Cerebral Circulation. Vinpocetine helps boost blood flow to and within the brain. Improving the flow of oxygen and glucose that feed ATP to power brain cells. Improving alertness, cognition, concentration, memory and mood.

• Neuroprotectant. Vinpocetine blocks the accumulation of sodium in neurons, reduces the toxic effects of oxidative stress, inhibits the enzyme PDE1 and boosting blood flow, scavenges free radicals, and protects neurons from glutamate and NMDA toxicity.

• Neuroplasticity. Vinpocetine inhibits the enzyme PDE1 which can increase cAMP and cGMP. These cyclic nucleotides in turn activate a series of kinases that phosphorylate the transcription factors cAMP response element binding protein (CREB) and serum response factor (SRF), leading to the expression of plasticity-related genes.[iii] Boosting neuroplasticity enhances cognition and memory.

Special Precautions and Warnings: webmd.com/vitamins/ai/ingre...

• Pregnancy: Vinpocetine is possibly unsafe when used during pregnancy or by those who may become pregnant. Vinpocetine might increase the risk of miscarriage and might cause harm to the fetus. Avoid using.

• Breast-feeding: There isn't enough reliable information to know if vinpocetine is safe to use when breast-feeding. Stay on the safe side and avoid use.

• Bleeding disorders: Vinpocetine might increase the risk of bleeding. Use cautiously if you have a bleeding disorder.

• Weakened immune system: Vinpocetine might weaken the immune system in some people. This might reduce the body's ability to fight infections. If you already have a weakened immune system, check with your healthcare provider before using vinpocetine.

• Surgery: Vinpocetine might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using vinpocetine at least 2 weeks before you are scheduled for surgery.

[PDWarrior1900 in reply to Bolt_Upright]

thanks for the tip! I just bought Vinpocetine on eBay -- they weren't available on Amazon ... and thanks for your inquiry about what my 'stack' is... there are so many (over 30) that I was just too tired (and frustrasssssssssssted) to take the time and list them... nothing has worked ... and i mean... NOTHING .... sauna... PEMF mat ... exercise ... supplements ... sunshine (when it's available) ... vibration plate machine ... eating fermented foods ... eating pomegranates ... lots of green veggies... and O.M.A.D. (one meal a day) ... Today is day #285 (all calories eaten within a 90 minute window).. I have lost 54 pounds (another 35 to go and I'll be back to my weight in my early 30's .... almost 40 years ago!) ... So now I just added . Vinpocetine ...

------------------------

Personally I think my PD is either in my gut or my mouth/teeth as the 'source.' I have never had a drink of alcohol in my life... never had a single recreational drug ... no cigarettes... no family history of any neuro diseases ... (my mom lived just short of 100; my aunt 101; my dad 87 and it was a bad blood transfusion of hep C that got him) ... so i hit the lottery on good genes....

------------------------

Terribly, terribly baffling how I got PD.

Even more frustrating that I haven't been able to stop it -- yet.

[Sydney75]

Wow! that's quite a list. Some have been studied (CO-Q10), B1 etc. Many never get the extensive study (pharma phases) because there is no $$ to be made or like C0-Q10 later phases showed no real improvement. Many of these supplements help some but not others in PD. I think it may be trial and error for many people and it get expensive.

We did glutathione pushes (IV) did not see much benefit after doing it for 1 year and it was expensive. Started NAC the precursor to glutathione (cheaper) but hard on the gastro system.

Supplments are a rabbit hole. Good Luck!

[JustJeff]

Exercise

[LindaP50]

I'm curious as to why you ask? You ask "which way should I go"? Do you have Parkinson's? Do you suspect your PD originated from mitochondrial damage? Do you have any other medical conditions? Tell us more information.

However, quickly looking down the list -

Alcohol? Red wine one glass daily could help some.

Doxycycline - don't know of anyone taking for PWP or those with Doxycycline (requires a prescription).

Artemisinin is used to treat malaria and for Lyme disease. A supplement to be taken under doctor's care as there are time limits.

[healthyheart7 in reply to LindaP50]

I have Parkinson’s disease for over 11 years. Set timer for trying various supplements with questionable responses. The problem is which studies of reliable, who do you trust, whichh brand has the best quality, dosage do you use and what frequency is best.

My personal feeling is that in large part Parkinson’s disease is related to mitochondrial dysfunction. I am concentrating my supplements on the mitochondria

[PDWarrior1900 in reply to healthyheart7]

what are you taking now? thanks for the feedback

[LagLag37]

BTW…. My user name changed from laglag to LagLag37. I was diagnosed almost 20 years ago and these are the things that I currently take: Of course, exercise is a given, especially Rock Steady Boxing.

5-6 25/100 Carbidopa/Levodopa

2 0.5 Azilect

2 GOCOVRI 137 mg each

Dark chocolate

Coconut oil

Vit D3

Emergen C

If I could only pick 2, I would pick:

1) carbidopa/levadopa

2) Emergen C

# 3 & 4

3) Dark Chocolate

4) D3

I would not pick Azilect because I don’t think it helps enough. I quit taking it about 2 yrs, with my doctor’s approval, and it did seem to affect my fine motor skills. I started taking it when it first came out and I’m back on it again. At that time they thought it slowed the progression, but now they’re not so sure. 🥊

[lbrussell]

I like the way Dr Laurie Mischley thinks about supplements, medications and other lifestyle targets in relation to PD progression. What are the people who are doing well and have the fewest symptoms 10 or 20 years into their diagnosis doing (or taking or eating or exercising)? Do what they are doing! Google Dr Mischley and you'll find great data from her Pro-PD studies. Plus, her Online PD School has a whole course on supplements. The most important thing to me: do not not take any supplements not warranted either by my own blood or hair tests, or other very strong, PD-targeted evidence. One person may be low on iron and need supplements and yet another might have too much. Since iron is very dangerous for PD brains, this means we all need to customize our list of supplements, nutrition and other lifestyle options. Think targeted medicine. Don't throw everything against the wall see what sticks. Good luck.

[healthyheart7 in reply to lbrussell]

Good answer, but what are they taking?

[lbrussell in reply to healthyheart7]

Dr Mischley's general recommendations for most PD folks include: glutathione, fish oil, CoQ10 and newly added, NAD+. Her personalized medicine supplements, conditional upon blood/hair levels include: lithium rotate, vitamin D, B-12, C, turmeric, DHEA, melatonin and homocysteine lowering supplements. Chapter 8 of PD School covers "Supplements & Nutraceuticals" extensively in 20 different videos. Chapter 12 covers "Conditionally Essential Nutrients in PD" in 10 videos. Both chapters have handouts and slides to download and very interesting Q&A sections as well. Good luck.