• Cerebral Circulation. Vinpocetine helps boost blood flow to and within the brain. Improving the flow of oxygen and glucose that feed ATP to power brain cells. Improving alertness, cognition, concentration, memory and mood.
• Neuroprotectant. Vinpocetine blocks the accumulation of sodium in neurons, reduces the toxic effects of oxidative stress, inhibits the enzyme PDE1 and boosting blood flow, scavenges free radicals, and protects neurons from glutamate and NMDA toxicity.
• Neuroplasticity. Vinpocetine inhibits the enzyme PDE1 which can increase cAMP and cGMP. These cyclic nucleotides in turn activate a series of kinases that phosphorylate the transcription factors cAMP response element binding protein (CREB) and serum response factor (SRF), leading to the expression of plasticity-related genes.[iii] Boosting neuroplasticity enhances cognition and memory.
• Pregnancy: Vinpocetine is possibly unsafe when used during pregnancy or by those who may become pregnant. Vinpocetine might increase the risk of miscarriage and might cause harm to the fetus. Avoid using.
• Breast-feeding: There isn't enough reliable information to know if vinpocetine is safe to use when breast-feeding. Stay on the safe side and avoid use.
• Bleeding disorders: Vinpocetine might increase the risk of bleeding. Use cautiously if you have a bleeding disorder.
• Weakened immune system: Vinpocetine might weaken the immune system in some people. This might reduce the body's ability to fight infections. If you already have a weakened immune system, check with your healthcare provider before using vinpocetine.
• Surgery: Vinpocetine might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using vinpocetine at least 2 weeks before you are scheduled for surgery.
thanks for the tip! I just bought Vinpocetine on eBay -- they weren't available on Amazon ... and thanks for your inquiry about what my 'stack' is... there are so many (over 30) that I was just too tired (and frustrasssssssssssted) to take the time and list them... nothing has worked ... and i mean... NOTHING .... sauna... PEMF mat ... exercise ... supplements ... sunshine (when it's available) ... vibration plate machine ... eating fermented foods ... eating pomegranates ... lots of green veggies... and O.M.A.D. (one meal a day) ... Today is day #285 (all calories eaten within a 90 minute window).. I have lost 54 pounds (another 35 to go and I'll be back to my weight in my early 30's .... almost 40 years ago!) ... So now I just added . Vinpocetine ...
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Personally I think my PD is either in my gut or my mouth/teeth as the 'source.' I have never had a drink of alcohol in my life... never had a single recreational drug ... no cigarettes... no family history of any neuro diseases ... (my mom lived just short of 100; my aunt 101; my dad 87 and it was a bad blood transfusion of hep C that got him) ... so i hit the lottery on good genes....
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Terribly, terribly baffling how I got PD.
Even more frustrating that I haven't been able to stop it -- yet.
Wow! that's quite a list. Some have been studied (CO-Q10), B1 etc. Many never get the extensive study (pharma phases) because there is no $$ to be made or like C0-Q10 later phases showed no real improvement. Many of these supplements help some but not others in PD. I think it may be trial and error for many people and it get expensive.
We did glutathione pushes (IV) did not see much benefit after doing it for 1 year and it was expensive. Started NAC the precursor to glutathione (cheaper) but hard on the gastro system.
I'm curious as to why you ask? You ask "which way should I go"? Do you have Parkinson's? Do you suspect your PD originated from mitochondrial damage? Do you have any other medical conditions? Tell us more information.
However, quickly looking down the list -
Alcohol? Red wine one glass daily could help some.
Doxycycline - don't know of anyone taking for PWP or those with Doxycycline (requires a prescription).
Artemisinin is used to treat malaria and for Lyme disease. A supplement to be taken under doctor's care as there are time limits.
I have Parkinson’s disease for over 11 years. Set timer for trying various supplements with questionable responses. The problem is which studies of reliable, who do you trust, whichh brand has the best quality, dosage do you use and what frequency is best.
My personal feeling is that in large part Parkinson’s disease is related to mitochondrial dysfunction. I am concentrating my supplements on the mitochondria
BTW…. My user name changed from laglag to LagLag37. I was diagnosed almost 20 years ago and these are the things that I currently take: Of course, exercise is a given, especially Rock Steady Boxing.
5-6 25/100 Carbidopa/Levodopa
2 0.5 Azilect
2 GOCOVRI 137 mg each
Dark chocolate
Coconut oil
Vit D3
Emergen C
If I could only pick 2, I would pick:
1) carbidopa/levadopa
2) Emergen C
# 3 & 4
3) Dark Chocolate
4) D3
I would not pick Azilect because I don’t think it helps enough. I quit taking it about 2 yrs, with my doctor’s approval, and it did seem to affect my fine motor skills. I started taking it when it first came out and I’m back on it again. At that time they thought it slowed the progression, but now they’re not so sure. 🥊
I like the way Dr Laurie Mischley thinks about supplements, medications and other lifestyle targets in relation to PD progression. What are the people who are doing well and have the fewest symptoms 10 or 20 years into their diagnosis doing (or taking or eating or exercising)? Do what they are doing! Google Dr Mischley and you'll find great data from her Pro-PD studies. Plus, her Online PD School has a whole course on supplements. The most important thing to me: do not not take any supplements not warranted either by my own blood or hair tests, or other very strong, PD-targeted evidence. One person may be low on iron and need supplements and yet another might have too much. Since iron is very dangerous for PD brains, this means we all need to customize our list of supplements, nutrition and other lifestyle options. Think targeted medicine. Don't throw everything against the wall see what sticks. Good luck.
Dr Mischley's general recommendations for most PD folks include: glutathione, fish oil, CoQ10 and newly added, NAD+. Her personalized medicine supplements, conditional upon blood/hair levels include: lithium rotate, vitamin D, B-12, C, turmeric, DHEA, melatonin and homocysteine lowering supplements. Chapter 8 of PD School covers "Supplements & Nutraceuticals" extensively in 20 different videos. Chapter 12 covers "Conditionally Essential Nutrients in PD" in 10 videos. Both chapters have handouts and slides to download and very interesting Q&A sections as well. Good luck.
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summary of a visit to my neurologist
Compounds that prevent a-syn misfolding
Parkinsons detox 
