Experiences with

Ursodeoxycholic acid

Hi everyone, I was recently diagnosed with Primary Biliary Cholangitis (PBC), and my doctor started me on UDCA. Unfortunately, I’m struggling to tolerate it. For those who have faced a similar situation, what alternatives worked for you? Did the alternatives provide results comparable to UDCA?

Diagnosis was this week and ursodeoxycholic acid prescribed, don't get to see gastroenterologist until May. Would like to know as much as I can beforehand and have suitable questions to ask. Thank you 😊

This is exciting news as it provides an additional second line therapy to be used in combination with Ursodeoxycholic Acid (UDCA) for patients who have had an inadequate response to UDCA alone or as a new treatment for patients who are unable to tolerate UDCA.

The paper below is the most detailed and well referenced I have read regarding UDCA and TUDCA. Incredibly thorough. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258966/#CR128

I could not take Azapriothine or Methotrexate but have settled reasonably happily with a daily routine of Bisoprolol, Levothyroxine, Amlodipine, Prednisolone, Ursodeoxycholic Acid, Losartan, Rosuvastatin and Famitidine.This is of course just my routine for my particular conditions.

I've been on ursodiol about 8 months now and for the past month or so have had brittle nails that have been breaking far enough in that it's not safe to cut off the broken part. Obviously there can be many causes such as diet or other diseases, but I wondered if anyone else has experienced this specifically

I was diagnosed with PBC in July 2021. I have been on Urso since my diagnosis. I take 600 mg daily. I had lab a week ago & don't have the results but I decided to quit the Urso. My liver enzymes has never gotten anywhere near normal. They have come down. I'm just stopping the Urso for a few months

Has anyone had any experience with taking montelukast ( generic for singulair) which I have taken for many years for asthma. I have been diagnosed with PBC and am taking Ursodiol; however, I do not have any fatigue or itching. My liver ultrasound and sonogram shows a normal liver. My gastroenterologist

Hello everyone, I've been taking ursodiol for 8 years, since diagnoses in September 2016. All this time, I've been taking 500 mg, two tabs a day, generic brand called Actavis. My pharmacy (Cigna-Express Scripts) was able to supply me this generic brand every time. This year my insurance Medicare Plan

I was diagnosed with PBC and 2017. My alkaline phosphate levels were 277. I was told I was gonna go in the liver transplant list or I was going to die. I was prescribed URSODIOL and Oclavia. My levels started to go down, but I was starting to have a reaction from the Oclavia, causing me to have eczema

Fibrates can be considered as off‐label alternatives for patients with PBC and inadequate response to ursodeoxycholic acid, although fibrates are discouraged in patients with decompensated liver disease. 10. OCA is contraindicated in patients with advanced cirrhosis.

Hi, I've been on urso 2000mg daily for 8 years now, but it seems to give me diarrhoea lately. Does anyone else have this trouble, also does it mean it has stopped working? Thank you for any help.

I have had PBC since 2004 with stable liver enzymes until approximately one year ago. I realize it may be disease progression but am wondering because I had an insurance company change just before their elevation and my new insurance company switched me to a different generic brand of ursodiol. Does

i’ve been on Urso for about two years now with good results and bringing my numbers back to the normal range. In the last year, I’ve been dealing with significant anxiety and I’ve not had this before. I am postmenopausal and have also been trying hormone replacement therapy in the form of patches and

Doctor had given me just one tablet ( ursodeoxycholic acid ) i have been taking that as well but they keep on going up . The Ratio is still normal though . Is this common in Fatty liver ?

I take 300mg of ursodiol 3 times a day and I’ve been taking this for 6 years. My only one problem is that I have never been able to swallow pills before and still can’t get it right. I been getting complaints from my dentist about cavities popping up often when I visit for fillings. I try to rinse

Anyone on here involved with the trial of Urso, a liver drug that showed so promise to treatment of PD Drug: ursodeoxycholic acid Subjects will be provided ~50mg/kg/day (based on the use of 250 and 500mg capsules) of UDCA to be divided into 3 equal daily doses and titrated up over ~2 weeks to a stable

The short version is, as the paper summarises, “these results suggest that the beneficial effects of ursodeoxycholic acid in PBC is mediated in part by immuno suppression”.

Hello Everyone, I was diagnosed in 2018 and have had no issues, as bloodwork abnormalities led to my diagnosis, rather than symptoms. Fortunately for me, after I began taking Ursodiol, I have had normal bloodwork also. However, I've bounced around providers, in part due to the pandemic, and in part

Biliary CirrhosisPrimary Biliary Cirrhosis – Condition and Symptoms The liver secretes bile, a bodily fluid that is essential for the body to digest fats. It also helps the body to rid itself of toxic substances, cholesterol, and worn-out red blood cells. The ducts that release bile can become damaged