Experiences with

Azilect

I’m learning other means of increasing dopamine to wean off of Azilect.

I was prescribed Azilect (dopamine agonist) which I’ve been on since. My doctor said that the effectiveness of Azilect was a confirmation of Parkinson’s and he therefore did not pressure me to get a DAT scan (brain scan) to further confirm my PD diagnosis.

Azilect was not mentioned specifically but increasing dopamine is a “cause of RLS augmentation.” Levodopa increases augmentation meaning it makes RLS worse. So thinking Azilect does was not necessarily incorrect. If you have PD and develop RLS, well, it is horrid.

My 69 year old HwP has had tremor dominant PD for the past 7 years - taking only Azilect (that he started a year ago). The tremor is much worse, embarrassing him at work, so he needs more therapy. Shooting pain in one foot (and numbness in both) is another recent problem.

I take Ritary, Azilect and carb/lev and had heart valve replacement surgery at the end of August. Lots of side effects including hallucinations. Haven’t found much history on this but hear it common with PWP’s.. Mogul 1

My Pd improved so much I considered stopping Azilect. Doctor said no need to wean. Just stop. I did. I was fine for about 10 days and I was elated! Then it HIT. Internal tremors that felt like what I believe seizures are like. My head felt like it was bouncing on the pillow.

I believe RASAGALINE Azilect has given me restless leg syndrome. Has anyone else had this experience? What I have read from various sources is that dopamine agonists are a short term fix for RLS but can make it much worse long term.

When I started Azilect I did not have RLS. Now I do and it is getting worse. I’m very fearful that it is going to be what pushes me over the edge in to a downward trajectory because RLS = poor or no sleep.

Hwp started Azilect a week ago and is quite nauseous from the med. Does the nausea get better with time? Have you found ways to mitigate this side effect that worked for you? Thank you in advance!

Today I went back to my old regime of Madopar 100/25 3 times a day and 1 Azilect. I feel fine again - but the twitchy leg is back. If I take 2 a day with the up to 12 hour gap I don’t have off periods and the twitching is much less.

Both compounds are approved therapies for Parkinson’s — marketed as Mirapex (pramipexole) and Azilect (rasagiline). The low doses used in P2B001 are not currently available on the market. https://parkinsonsnewstoday.com/news/new-phase-3-trial-data-back-p2b001-therapy-early-parkinsons/

Does anyone benefit from this?Thanks

Most bang for your bucks Carbadopa/Levadopa  L-5-hydroxytryptophan (5-HTP) Actylcholine Actigal/Ursolic acid Adderil (amphetamine) Alcohol Alpha GBC Alpha-Ketobutyric acid Alpha Lipoic Acid Amantadine Artemisinin Ashwagandha Astragalus Azilect Berberine BioVie Brain derived neurotropic

Based on my neurologist prescription I am actually taking weekly b1 injection and 07h 1 azilect, 1 requip 2mg, 1 madopar 125mg capsule and i feel fine 12h 1 madopar 62.5mg capsule et 1/4 madopar comprimé and i feel not so fine, a bit slow 17h 1 madopar 62.5mg capsule et 1/4 madopar comprimé, 1 requip

I believe that Azilect, an MAOB inhibitor that increases available dopamine might be a cause of my having RLS. brain?“Inflammation – The Connecting Factor in Almost Every Restless Legs Case…”3.

I believe that Azilect, an MAOB inhibitor that increases available dopamine might be a cause of my having RLS. brain?“Inflammation – The Connecting Factor in Almost Every Restless Legs Case…”3.

®) [125] (Figure 2) thus inheriting some of their neuroprotective/neurorestorative properties and have additional neurorestorative activity associated with the introduction of a propargylamine monoamine oxidase (MAO) inhibitor moiety of anti-Parkinson drug rasagiline (Azilect®).

This despite the initial effectiveness of the standard medication L/C (increased from 400/40 in a relatively short time to 1000/130) + Azilect.

Rasagiline (Azilect®) Available Doses: 0.5 mg, 1 mg doses. ... Safinamide (Xadago) Available Doses: 200 mg.

Grapefruit and Azilect (MAO-B) safe interaction? Getting mixed input on web search. Looking at some supplements, and occasionally grapefruit pops up in the ingredients. Any thoughts appreciated. Thanks!