Experiences with

Dopamine

Maybe someone can help explain the effect of magnesium on dopamine levels.I thought a dopamine agonist was helpful in calming rls. Magnesium is an antagonist so decreases dopamine levels, yet is touted as effective in controlling rls. Don't know if I'm making any sense here.

Editing my edit: (yes, I know, but I’m trying) Not only do dopamine agonists make RLS worse but so do meds that increase dopamine. Azilect was not mentioned specifically but increasing dopamine is a “cause of RLS augmentation.” Levodopa increases augmentation meaning it makes RLS worse.

https://mybiohack.com/blog/all-ways-increase-dopamine-naturally

I read that levodopa carbadopa increases your blood level of glucose does anyone take any non-dopamine therapy that works when I take levadopa I can’t stand up. And all of my te tendons, get weak and burn. I also have Lyme disease I’ll read that to her and dopamine enhance Lyme disease.

And, I now think the dopamine agonists are prodding the tired dopamine receptors until they die instead of nurturing them back to health.)

Cell replacement therapy makes dopamine nerve precursor cells from stem cells derived from the midbrain of the fetus. Then, dopamine nerve precursor cells can be transplanted into the patient's brain.

And, I now think the dopamine agonists are prodding the tired dopamine receptors until they die instead of nurturing them back to health.) 

In particular, the team found that the naturally occurring molecule 5,6-dihydroxyindole (DHI), a dopamine metabolite, binds directly to and modulates the activity of Nurr1. https://parkinsonsnewstoday.com/news/new-parkinsons-strategy-targets-nurr1-protein/

The symptoms of Parkinson’s are caused by the loss of dopamine-producing nerve cells or neurons in the brain; and researchers have long proposed using cell transplantation as a treatment option for replacing these lost dopamine cells.

So low seratonin kicks off the loop or cascade that culminates in low dopamine. Would increasing seratonin have a disease modifying affect or just aid in more dopamine and reduce symptoms?

https://area1255.blogspot.com/2015/05/how-to-preventreverse-dopamine-receptor.html “While it is certainly notable that many neurodegenerative diseases can cause malfunction in dopamine neurons (Parkinson's, MS, Infections, FMNP, CFS) - that doesn't mean that dopamine issues can not occur without their

"Discontinuation of dopamine agonists because of severe augmentation or other adverse effects and substitution of a drug of a different class (such as an alpha2-delta ligand) can be achieved in 2 ways.

Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108570/

The neurologist prescribed a low dose of an oral dopamine agonist but it made him too sleepy. He is now offering a choice between trying Artane, or a Neupro (dopamine agonist) patch, perhaps left on only during the day, or commencing low dose Madopar. Does the community have thoughts on this?

I’m learning other means of increasing dopamine to wean off of Azilect.

My guess is it’s because of his dopamine beta hydroxylase running fast, (genetic testing picked this up) breaking down the dopamine too fast so it runs out too quickly and causes rigidity and anxiety.

Why does https://www.rls-uk.org/faqs still say under Treatments for RLS "Dopamine agonists are often recommended for people with more frequent symptoms. These include ropinirole, pramipexole and rotigotine."

This was the answer I got: "Chronic inflammation can contribute to the dysfunction of the dopamine system by damaging the dopaminergic neurons in the brain. This can lead to a reduction in dopamine levels, which can cause the symptoms of RLS.

The study will evaluate the safety and efficacy of dopamine neural precursor cell transplantation therapy derived from homogeneous embryonic stem cells in patients who have been diagnosed with Parkinson's disease for more than five years.

Parkinson's has a long presymptomatic period, it's caused for the newborn, from magnesium deficiency during pregnancy & nursing which makes it so fewer dopamine nerves are created. https://www.ncbi.nlm.nih.gov/books/NBK507269/#_NBK507269_pubdet_