Experiences with

Tyrosine

It has vitamin A, vitamin C, riboflavin, zinc, selenium, copper (all 100% apart from vit C - 278%) , ashwagandha, L-Tyrosine, guggui gum extract

I think I may test my iodine and tyrosine levels next! Ever learning. Love and Peace.

Bruton’s tyrosine kinase (BTK) degraders are a new class of medications that have potential to be effective in this scenario. This review describes the mechanism of action of BTK degraders, and their pre-clinical and clinical development to date, including emerging clinical trial data.

Since I know I'm chronically low in dopamine and that L tyrosine benefits me in other ways, I decided to try trickle dosing. I got some L Tyrosine powder from Bulk Supplements.

I've just read a study published in the British Journal of Cancer (August 2024) that looked at the possible role of CLL in accelerating SCC development due to receptor tyrosine kinase AXL secretion (https://pubmed.ncbi.nlm.nih.gov/38886556/).

The mutation, converting phenylalanine to tyrosine, basically adding a hydroxyl, seems kinda minor but my biology diploma is 50 years old (I moved to chemistry and materials for my career but stayed interested in molecular biology - a dilettante).

AJ1-11095 is a novel orally bioavailable small molecule type II non-covalent tyrosine kinase inhibitor that binds both the active and inactive conformations of JAK2 and prevents heterodimerization with JAK1 and TYK2, overcoming a common mechanism of clonal persistence and drug resistance to type I inhibitors

The Phase 3 HERCULES trial showed tolebrutinib, an oral Bruton's kinase (BTK) inhibitor, delayed the time to onset of 6-month confirmed disability progression by 31% compared with placebo.

Anyone seen this? This is what JSBMD is talking about https://pmc.ncbi.nlm.nih.gov/articles/PMC11083272/#sec6-ijms-25-04643 Conclusions TH inhibitors down-regulate DA levels and protect DA neurons, while DA receptor agonists function to activate post-synaptic DA receptors to alleviate PD symptoms

randomized trial with 238 patients, with my emphasis; https://www.medpagetoday.com/meetingcoverage/ashhematology/113337 [i]Pirtobrutinib (Jaypirca) delayed disease progression versus other available options in patients with chronic lymphocytic leukemia (CLL) who had previously received a covalent Bruton's tyrosine

Approvals of multiple covalent Bruton's tyrosine kinas inhibitors (cBTKis) as well as the B-cell lymphoma-2 inhibitor (BCL2i) venetoclax targeting these pathways have revolutionized the treatment of CLL and small lymphocytic lymphoma (SLL).

Hello, I'd like to take Tyrosine to support my sluggish thyroid. I see that many brands offer two forms of tyrosine: L-Tyrosine and Acetyl l Tyrosine. The latter seems to be more bioavailable but with a lower absorption rate Which form is anyone taking? Thank you

Rocbrutinib is a new drug offering hope to patients with what are known as gatekeeper mutations that confer resistance to Pirtobrutinib. This BTKi is unique in being both a covalent and non covalent inhibitor of BTK. Patients with gatekeeper mutations have poor outcomes and short survival and demonstrate

Any negative effects anyone has had with Tyrosine? I went through prior posts but could not find much on this. Thank you for any information you can provide. Have a fabulous day!!!

Methods: The therapeutic efficacy of curcumin was evaluated using behavioral tests, immunofluorescence of tyrosine hydroxylase (TH). Network pharmacology and transcriptomics predicted the mechanisms of curcumin in PD.

' 'L-theanine shields the dopaminergic neurons from degeneration and improves the number of hydroxylase-positive cells. ' ' The principal mechanism involves reducing neuroinflammation, precisely astrogliosis, and diminishing NOS-positive neurons.

In addition, I got a Bulk Supplements package of L-tyrosine powder. Meaning it does not have anything else in it -- no magnesiun stearate, no capsule, etc. And I dissolved 1/4 teaspoon in the measured water I drink daily.

My son bought L-Tyrosine for me, and said it helps PD by research, it can help you make dopamine . It is a kind of Amino Acid. My doctor said that you can try it, but, should not take it with levodopa the same time, should take it apart from levodopa. Has someone tried it ?

A CD19-directed cellular therapy, liso-cel is the first CAR-T product specifically for CLL/SLL; the one-time infusion is indicated for patients with relapsed or refractory disease following two or more prior therapies, including both a BCL-2 inhibitor such as venetoclax (Venclexta) and a Bruton's tyrosine

., Bruton tyrosine kinase (BTK) inhibitors such as ibrutinib (Imbruvica) or the BCL-2 inhibitor venetoclax -- "the treatment of patients with Richter transformation remains a crucial unmet need," they said.