Osteoarthritis: Prevented with Diet & Exercise? University of Surrey (U.K.) study in 'Nature Reviews Rheumatology'

Osteoarthritis: Prevented with Diet & Exercise? University of Surrey (U.K.) study in 'Nature Reviews Rheumatology'

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Osteoarthritis: Prevented with Diet & Exercise?

University of Surrey (U.K.) study in 'Nature Reviews Rheumatology'

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Press release that may interest those of us with Osteoarthritis (OA), Rheumatoid Arthritis (RA), and/ or other (or multiple) autoimmune conditions:

Osteoarthritis could be prevented with good diet and exercise: surrey.ac.uk/mediacentre/pr...

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(Text is copied below for convenience.) 🙏 🍀 🌺 🌞

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  • Osteoarthritis could be prevented with good diet and exercise: surrey.ac.uk/mediacentre/pr...

    Osteoarthritis can potentially be prevented with a good diet and regular exercise, a new expert review published in the "Nature Reviews Rheumatology" reports.

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    During the expert review, researchers from the University of Surrey identified a crucial link between metabolism and osteoarthritis. Metabolic changes, caused by a poor diet and a sedentary lifestyle, trigger’s the genetic reprogramming of cells in the body and joints.

    Such metabolic changes impact upon the cells ability to produce energy, forcing it to generate alternative sources to function. The stress this places on cells leads to the overproduction of glucose, which when not used for energy transforms into lactic acid, which is difficult for the body to flush out. Abnormal levels of this acid in the body leads to the inflammation of the joint’s cartilage which impedes on movement and causes pain.

    By identifying metabolic changes in cells, it is potentially possible to control or significantly slow down the symptoms of osteoarthritis, alleviating the suffering of millions of people.

    Osteoarthritis is the most common form of arthritis in the United Kingdom with 8.75 million people seeking medical advice for the condition. This debilitating condition disproportionately affects post-menopausal women who are more pre-disposed to the condition because of biology, genetics and hormones. Currently there is no effective treatment for this painful ailment, with only painkillers available to treat symptoms and no known cure.

    Lead author Professor Ali Mobasheri, Professor of Musculoskeletal Physiology at the University of Surrey, said: “For too long osteoarthritis has been known as the ‘wear and tear disease’ and it has been assumed that it is part and parcel of getting older. However, this is not the case and what we have learnt is that we can control and prevent the onset of this painful condition.

    “It is important never to underestimate the significance of a healthy diet and lifestyle as not only does it impact upon our general wellbeing but can alter the metabolic behaviour of our cells, tissues and organs leading to serious illnesses.”

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  • The referenced University of Surrey study in 'Nature Reviews Rheumatology':

    The role of metabolism in the pathogenesis of osteoarthritis: nature.com/nrrheum/journal/...

    (As 10-page pdf file if you prefer: nature.com/nrrheum/journal/... )

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    Abstract

    Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative proteins, which in turn activate key transcription factors and inflammatory signalling pathways involved in catabolic processes, and the persistent perpetuation of drivers of pathogenesis. In the past few years, several studies have demonstrated that metabolism has a key role in inflammatory joint diseases. In particular, metabolism is drastically altered in osteoarthritis (OA) and aberrant immunometabolism may be a key feature of many phenotypes of OA. This Review focuses on aberrant metabolism in the pathogenesis of OA, summarizing the current state of knowledge on the role of impaired metabolism in the cells of the osteoarthritic joint. We also highlight areas for future research, such as the potential to target metabolic pathways and mediators therapeutically.

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  • Conclusions

    The pathogenesis of OA involves metabolic alterations in articular cartilage, subchondral bone and synovium. These changes influence metabolic pathways in chondrocytes, synoviocytes and bone cells and their interactions with the immune system via inflammatory mediators. Accumulating evidence suggests that a metabolic switch towards glycolysis is important for immune responses and the activation of inflammatory pathways in chronic diseases, including OA and RA. This change in metabolism enables immune and inflammatory cells to gain energy to meet the increased demands for the biosynthesis of proinflammatory and degradative proteins during periods of acute cellular stress or nutrient deprivation. Similar mechanisms seem to operate in cells of the synovial joint in OA. A deeper mechanistic understanding of these complex metabolic pathways is therefore likely to provide insight into potential novel therapeutic strategies for treating OA and other inflammatory diseases of joints. At this point, research into immunometabolism in OA is still in its infancy; however, if the availability of glucose and oxygen are impaired in immune cells in OA, then regulators such as mTOR, AMPK and hypoxia-inducible factor 1α represent potential starting points for the discovery of therapeutic targets. An improved understanding of physiologic and pathophysiologic regulators of cartilage and synovial metabolism is also likely to provide new insights into the aetiology and pathophysiology of OA. Omics techniques such as metabolomics are likely to identify some of the underlying metabolic changes in OA131 and help to define the metabolic phenotype of OA132, 133, especially in the early stages of disease134. When combined with proteomics, lipidomics and bioinformatics, metabolomics will help to reveal the pathways, proteins and metabolites that drive inflammatory processes in synovial joints, hopefully also revealing new therapeutic targets. Future research should also focus on delineating the role of metabolism in macrophages that infiltrate the synovium in OA and in FLS in OA.

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  • Reminiscent of what Dr. Neal Barnard & Dr. Dean Ornish discuss — genes not being our destiny, turning genes on & off/ reprogramming . . .

    yada, yada, yada . . .

    The kind of talk that gets your rheumatologist looking at you like you've 2 heads 🙃🙃 . . . 😂 😂 😂 . . .

    (Dean Ornish, Neal Barnard, T. Colin Campbell, Caldwell Esselstyn, John McDougall, Michael Klaper, Michael Greger: healthunlocked.com/nras/pos... )

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