Latest results, thoughts appreciated.

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Hi,

I hope everyone is staying safe and strong in these difficult times.

I have just received these blood test results following taking the following medication/vitamins for 3 months:

1. Ferrous Sulfate 200mg twice daily (started 13/7, ended 4/10/20)

2. B Complex (started 27/7, ended 18/10/20)

3. Vitamin D 4,000iu alongside Vitamin K2-MK7 and Magnesium (started 27/7, ended 18/10/20)

All were fasting tests taken 4th November at 9.10am:

FULL BLOOD COUNT (NHS)

Haemoglobin estimation 123 g/L (115 - 160)

Total white cell count 6.1 10*9/L (4.0 - 11.0)

Platelet count 167 10*9/L (150 - 450)

Haematocrit 0.37 (0.37 - 0.47)

Red blood cell (RBC) count 4.15 10*12/L. (3.90 - 5.60)

Mean corpuscular volume (MCV) 88.4 fL (80.0 - 100)

Mean corpusc. haemoglobin (MCH) 29.6 pg (27.0 - 32.0)

Mean corpusc. Hb. conc. (MCHC) 335 g/L (320 - 360)

DIFFERENTIAL COUNT

Neutrophil count 3.5 10*9/L (1.8 - 7.7)

Lymphocyte count 1.8 10*9/L (1.0 - 4.8)

Monocyte count 0.5 10*9/L (0.1 - 1.0)

Eosinophil count 0.2 10*9/L (0.0 - 1.0)

Basophil count 0.1 10*9/L (0.0 - 0.1)

MEDICHECKS TESTS

RETICULOCYTE COUNT BLOOD TEST

Reticulocyte Count % 1.14% (0.45 - 2.42)

Reticulocyte Antibodies 50.0 x10^9/L (19.6 - 101.9)

DIET & LIFESTYLE CHECK

Kidney Health

Urea 4.10 mmol/L (2.5 - 7.8)

Creatinine 91umol/L (45 - 84)

eGFR 57.24 ml/min/1.73m2 (>60 unless evidence of CKD)

Liver Health

Bilirubin 9.70 umol/L (< 21)

ALP 51.00 IU/L (< 130)

ALT 20.30 IU/L (< 35)

GGT 15.00 IU/L (6 - 42)

Proteins

Total Protein 72.20 g/L (60 - 80)

Albumin 41.00 g/L (35 - 50)

Globulin 31.2 g/L (19 - 35)

Diabetes

HbA1c 33.64 mmol/mol (20 - 42)

Cholesterol Status

Total Cholesterol 4.73 mmol/L (0 - 5)

LDL Cholesterol 1.85 mmol/L (< 3)

Non HDL Cholesterol 2.22 mmol/L (< 4)

HDL Cholesterol level 2.51 mmol/L (> 1.3)

Total Cholesterol : HDL 1.88 (< 4)

Triglycerides 0.82 mmol/L (< 1.7)

Gout Risk

Uric Acid 189.00 umol/L (140 - 360)

Muscle Health

Creatine Kinase 55.00IU/L (26 -192)

Iron Status

Iron 22.08 umol/L (5.8 - 34.5)

TIBC 69.38 umol/L (45 - 72)

UIBC 47.30 umol/L (24.2 - 70.1)

Transferrin Saturation 31.82 % (20 - 50)

Ferritin 20.00 ug/L (13 - 150)

Vitamins

Folate - Serum 12.63 ug/L (> 3.89)

Vitamin B12 - Active 97.500 pmol/L (> 37.5)

Vitamin D 86.10 nmol/L (50 - 175)

THYROID CHECK PLUS

TSH 2.37 ml/U/L (0.27 - 4.2)

Free T3 4.33 pmol/L (3.1 - 6.8) so 33.24% through range (as per thyroid hormones original calculator)

Free T4 13.100 pmol/L (12- 22) so 11% through range (as per thyroid hormones original calculator)

Thyroglobulin Antibodies <10 klU/L (< 115)

Thyroid Peroxidase Antibodies <9.0 klU/L (< 34)

I am pleased to see that my folate has improved following my Vitamin B course, (previously 4.2), so I intend to resume this, although I still have some way to go.

I am also pleased to see further improvement in my Vitamin D level, (previously 64.3), although it is still lower than I had hoped. I was aiming to reach 125 as recommended by the Vitamin D Council. I am unsure what dose I need to take to further improve this for a retest in 3 months. Should I stay at a dose 4,000iu per day?

My haemoglobin estimation is now back in range (previously 110 on 1/7/20, pre last course of Ferrous Sulfate), and my Ferritin too (previously 7). However, I hoped both of these readings would be higher given my course only ended one month ago.

I was wondering whether the bouts of anaemia I am having could be attributable to a bone marrow problem which is why I decided to have a Reticulocyte test also. However, I do not know whether I should have had this test so soon after my course of iron to get a true indication of whether this is the case. Any guidance on this would be appreciated.

My TSH reading is lower (previously 3.2) and my Free T3 and Free T4 has decreased too (previously 4.85 and 14.100 respectively). I do not know the significance of this and wonder whether the thyroid has any bearing on the other matters, i.e. is my thyroid not part of the problem or if it is related, is it that it is not the source but a consequence of?

Although I feel I have made progress since my last post I still feel a little overwhelmed with all that I am trying to make sense of, particularly as my latest results show 2 of my 3 kidney health bio markers to be out of range too (Creatinine over range and eGFR under range).

I am truly grateful for this facility to enable me to reach out for help and advice, thanking you in advance for your time.

[SlowDragon Administrator]

I replied with research links on previous post

Suspect you need to look in-depth at isotretinoin as possibly causing thyroid disruption

[silverfox7]

I wasalways told that if you need to supplement it’s usually for life! I would add to that it depends on your starting amount but usually most of us are low on at least one so get everything you to scratch then taking one at a time so what you need to take to keep things optimal but do one at a time as easy to get confused.