Ordering a-Syn blockers in bulk. Master list of nutrients for PD.

[zawy]

I'm going to order the following plant extracts in bulk from China as powders and mix them for storage and later mixing in drinks.

I'll dump the powders in a 5 gallon bucket, shake, bottle, and label according to FDA. I'm already taking about 2/3 of them. Let me know if I'm missing anything. I take 1 tablespoon of the powder twice a day mixed in a juice/wine.

The dose simulates the animal and test tube research. Doses are between 200 mg and 2000 mg daily doses, but usually 500 mg to 1000 mg twice a day. So it's the equivalent of 30 pills per day, replaced by 2 bad-tasting drinks.

List of nutrients to be included in my next batch, not a-Syn blockers

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fisetin (strawberries)

apigenin (chamomile, parsley, celery, and in bee products, an MAO-AB inhibitor)

nobiletin (from citrus, may not include if the taste is too bad)

hesperidin (citrus, etc, very common)

Heptamethoxyflavone HMF (citrus)

citicoline (helps memory in AD, dopamine receptors, is bioavailable, neuroprotective, hormones (TSH, GH, TSH)

a-Syn blockers to be included (bioavailability possible but not known by me):

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naringin (the grapefruit bitterness)

gallic acid (from nutgall, black tea, teas, grapes, berries)

myricetin (bayberry bark)

morin (guava, osage)

Nordihydroguaiaretic acid

Genistein (ginseng)

cuminaldehyde (cumin)

quercetin (apples)

Considering:

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inosine (raises urate, should not take too much, raises activity of other compounds)

Tangeretin (tangerine, very expensive but requires only 1/5 as much as others)

alpha-lipoic acid

acetyl-L-carnitine

NAC

creatine

CoQ10

black tea extract (in case gallic acid is the not the primary benefit)

rutin (like quercetin)

peperine (for increasing bioavailability of some, hot taste will be tough to swallow straight)

Works or may work in PD and advisable in my opinion and not listed above included:

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Best evidence: nicotine (causes temporary imbalance and nausea), vitamins A, B's, D, E, fish oil, omega 3's from canola or flax, zinc, magnesium, melatonin, caffeine, 5-HTP, an NSAID like aspirin or ibuprofen, ellagic acid in olive and canola oil.

Whole extracts or foods: blueberry, apple, strawberry, teas, grape seed, beer, sardines.

Others with possibility: Co-Q10, theanine, selenium. Less evidence for: Mucuna pruriens, fava/broad beans, Bacopa monnieri, Gotu Kola, Ashwagandha. Bioavailable? PQQ, resveratrol, curcumin.

Not part of my a-Syn blockers/breakers listed above due to questions about bioavailability

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baicalein (skullcap flower, oxidized this breaks up existing a-Syn possibly like no other, seems completely unable to make it past liver to brain)

berberine (not strongly bioavailable, but can be helped with verapamil)

rosmarinc acid blocks a-Syn aggregation, but does not appear to be bioavailable.

resveratrol

curcuminoids

palmitoylethanolamide (PEA) is not orally bioavailable. (increases neurosteroidgenisis, affects cannaboid receptors, reduces inflammation and pain, improves mouse model for PD "Our results indicate that the PEA is neuroprotective even when administered once the insult has been initiated." ncbi.nlm.nih.gov/pmc/articl...

Pharmaceuticals useful in PD:

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L-DOPA, rasagiline, Ritalin, SSRI anti-depressants, synthetic triterpenoids, statins, ferriprox (iron chelator for PD), Nilotinib/Bafetinib/Dasanitib ($100,000 per year)

Warnings about drug interactions (not complete). These will amplify or reduce effects of some drugs by affecting liver enzymes. See the links for which pharmaceuticals are affected. This is more important than "grapefruit" interactions because the doses I want to take are very very high compared to grapefruit.

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quercetin: en.wikipedia.org/wiki/CYP2C8

piperine, curcumin, baicalein: en.wikipedia.org/wiki/CYP3A4

quercetin, naringin, naringenin, hesperitin: en.wikipedia.org/wiki/CYP1A2 and en.wikipedia.org/wiki/CYP3A4

apigenin: en.wikipedia.org/wiki/CYP2C9

tangeretin, nobiletin: SULT1A1

quercetin, naringin: SULT1A3 which increases beta(2) agonists (asthma)

Taking peperine, curcumin, naringin, and baicalein at same time can amplify each other.

Blocking CYP1A2 increases rasagiline

ncbi.nlm.nih.gov/pubmed/265...

notes:

citrulline: could not find support for it.

[Hidden]

zawy,

Pharmaceuticals:

For citruillne you may be looking for 'sertraline'. It is an antidepressant. If anybody has RLS do not take this. It exacerbates RLS a lot.

One that does not is Wellbutrin(or its generic). As far as I can tell it is the only one that doesn't. This information came from my neurologist who handles my PD, RLS and insomnia.

[KERRINGTON]

Hello ! How are you making out this October 2018, three yrs after this post of yours which I was drawn to because I had just been reading about apigenin ?

[Fumaniron in reply to KERRINGTON]

interested in thoughts for apigenin, as well.

[kaypeeoh]

I probably don't understand something. I know alpha synuclein is found on autopsy in the brain of PD patients. Does that mean it causes disease? Is it possibly coincidental? Is it possibly a positive effect, similar to white blood cells in abscesses? A deep abscess elevates the white blood count. First thought is high white count means disease. But white blood cells are attacking the infection. If the white blood count decreases over time that's a good indicator that it's curing the infection.