Experiences with

Levodopa

I certainly was not aware of that until my levodopa stopped working. I wonder why a Neurologist would not inform his patients with Parkinson's about such a serious drug interaction. drugs.com LORazepam can decrease the effects of in some people.

Also, were you adviced by your Neurologist that you need to adjust the dose of the levodopa you were taking at the time as Lorazepam makes levodopa ineffective? drugs.com LORazepam can decrease the effects of in some people.

This seems very promising https://parkinsonsnewstoday.com/news/study-review-highlights-limits-levodopa-effectiveness/

The plasma half-life of levodopa is about 50 minutes, without carbidopa. When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?

Is there a definitive impact to how h.pyloi affects levodopa absorbtion?

I am not sure my muscle spasm/ dystonia is caused by levodopa itself or amandatine. anyone has experience?

I already have movement disorders after less than two years with an daily input of 3 x 100 mg Levodopa. Who has the same symptoms at such an early stage and what is your experience? Have you found out what is helpful?

Miller, PhD, a professor at Columbia University, will assess how to prevent further damage of dopamine-producing neurons by levodopa and its derivatives. Levodopa is the precursor of dopamine and a gold standard therapy for Parkinson’s that effectively reduces early motor symptoms.

female PD patient complicated with dopamine-induced FOG, which was identified during levodopa challenge test. Her symptoms were alleviated after adjusting the medication. https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2024.1464152/full#SM1

dyskinesia compared with immediate-release levodopa/carbidopa (IR-LD/CD) at week 12.

This is the first and only 24-hour continuous subcutaneous infusion levodopa-based therapy for treating motor fluctuations in this population.

Levodopa meds don’t do much for me, I say that I feel like bad crap on the meds and really bad crap off the meds,. Does anyone else have the punch drunk feeling in off time and/or levodopa not really helping a lot?

For the trial, 381 patients with Parkinson's disease in 16 countries were randomised to receive continuous subcutaneous infusion of levodopa, or oral levodopa.

Early levodopa initiation in Parkinsons does neither postpone nor accelerate mortality or PD-related complications, nor does it precipitate earlier occurrence of PD-related complications or mortality https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mdc3.14174

Extreme gait issues which have been treated with higher dosages of Levodopa. I am experiencing body pain when I get close to my next dose, which is down to a 3 hour interval. Could the pain be withdrawal as my dosage is usually worn off by then?

I’ve found a way to use Levodopa, and it finally works for me—previously, I had very negative effects. In short, I take it not before going to bed but after I start experiencing RLS symptoms.

I can try this for 2-3 weeks, then stop if I feel to, then restart the levodopa at any time. This treatment should not be expected to have any positive impact on my balance issues or drooling.

Anyone taking Nourianz and Gocovori together with Carbidopa /Levodopa? I am following this regimen which has been largely benign. Just wanted to know if anyone else has experiences to share.

Anyway, during Mums period of fixating that the Parkinson’s levodopa medication has some sort of super power and is the answer to everything that isn’t working with her, she’s been calling the Parkinson’s nurses trying to increase the levodopa. They are hesitant due to her blood pressure.

What do you do when carbidopa-levodopa "off" times get inconsistent, more frequent, or it seems the C/L didn't work at all? I get extremely uncomfortable, uncoordinated and so incredibly weak.Thank you!