Experiences with

Levodopa

New prescription is (1) ER 25/100 levodopa before bed, (1) entacapone & (1) 25/250 levodopa upon rising, (1) entacapone & (1) 25/100 levodopa at 11am, (1) 25/100 levodopa at 2pm, and (1) entacapone & (1) 25/100 levodopa at 5pm. Total levodopa is now 650mg/day.

My understanding is that levodopa needs to reach and be absorbed in the small intestine, so the drug needs much time to kick in. There are times however, when the levodopa is needed right away. Does anyone recall the post to have thoughts about getting levodopa absorbed faster?

Where might negative levodopa be useful: - as we have seen, reducing levodopa induced dyskinesia; - response to mistakenly taking a double dose - as soon as you find the mistake eat protein; - smooth out the peaks in levodopa levels.

My neurologidt prescribed it to me (50mg.) to take in combination with levodopa. Its function should be to neutralize those enzymes that degrade levodopa so as to make "on" effect more lasting. It only worked for me a few months.

Hello, Does Levodopa help a person who Has symptoms of mild cognative impairment with early onset PD? TIA Steve

Summary: Levodopa, a drug commonly prescribed for the treatment of Parkinson’s disease that increases dopamine in the brain was found to reverse the effects of neuroinflammation on the reward system and improve symptoms associated with depression. https://neurosciencenews.com/levodopa-inflammation-depression

BBB = Blood Brain Barrier CD = Carbidopa CD/LD = Comination of carbidopa and levodopa C/L = Carbidopa/levodopa CNS = Central Nervous System CR = Controlled Relase DA = Dopamine agonist DBS = Deep-brain stimulation DX = Diagnosis ER = Extended Release ET = Essential tremor Hcl = hydrochloride

h=c5d18a3956 https://www.oruen.com/home-video/levodopa-mythology-dr-alberto-espay Levodopa mythology revisited — a 20-minute tour of the things we once believed about the most important replacement therapy https://twitter.com/AlbertoEspay/status/1584886343124910080

https://parkinsonsnewstoday.com/news/trial-mesdopetam-levodopa-induced-dyskinesia-nears-end/ Mesdopetam is designed to block a dopamine receptor protein called D3 receptor, whose levels are increased in motor-related brain regions with prolonged levodopa treatment and associated dyskinesia.

Do pwp experience on times and off times when they’re on Neupro patches like they do with Levodopa and other Parkinson’s medication?

https://www.pdr.net/drug-summary/Sinemet-CR-carbidopa-levodopa-389.1769 Does anyone know the reason and possibly the link of the medical justification for this recommendation? Merci 🍀

If I understand correctly this therapy "is a co-adjuvant therapeutic measure to use with levodopa therapy". Does it mean this therapy won't have any effect on my friend not taking levodopa? They are taking amantadine and pramipexole. Can B1 therapy help?

I read that levodopa carbadopa increases your blood level of glucose does anyone take any non-dopamine therapy that works when I take levadopa I can’t stand up. And all of my te tendons, get weak and burn. I also have Lyme disease I’ll read that to her and dopamine enhance Lyme disease.

Occasionally I take Ibuprofen 400 mg once in a week or so and it fortifies the effects of levodopa by three times or higher. Wondering if there are any studies available on ibuprofen use for PD. Are there any negative side effects of its use for long ? Or long term positive effects for PD:

Carbidopa and Levodopa and Amantadine

Is anyone on the high dosage of vitamin B1 therapy and for those who are, are you also taking any meds for Parkinson's like "Levodopa"?

Hi folks Taking Levodopa Gabapentin and Tramadol for Parkinson and Restless legs and get bad constipation can you suggest any good things to take to help this .

There has been much concern that levodopa hastens the progression of PD. Many studies have found this not to be the case.

https://medicalxpress.com/news/2022-08-otc-supplements-high-levodopa-paranoia.html

Adverse events led to premature discontinuation of study drug in 16 (22%) of 74 participants in the foslevodopa-foscarbidopa group versus one (1%) of 67 participants in the oral levodopa-carbidopa group.