Experiences with

Levodopa

Has anyone tried this to manage FND symptoms? My gp gave me a 7 day trial, by 3rd day my jerks had decreased, which was my main concern. Just not sure of adding another med to my long list of medications. Or whether more symptoms will decrease. Would like to hear from others who had success. Take care

My husband has been prescribed Levodopa but has MSA -C . I appreciate we are all different but wondered what experiences people have had ? Side affects ? Benefits etc . He has been to take 150mg daily , is it usual to start low and gradually increase ?

How safe is Levodopa? I'm looking for a recent post on side effects of Levodopa? What are the side effects? What symptoms does it improve? How many people in this group are taking Levodopa and have h ad positive results Thanks for your help

https://parkinsonsnewstoday.com/2021/12/07/oral-molecule-lessens-levodopa-induced-dyskinesia-in-parkinsons-primate-model/

Might a standard 100/25 C/L tablet be as powerful as 500mg of levodopa from mucuna? And are there deleterious effects from the extra levodopa in the non-brain blood system when taking higher amounts of mucuna-sourced levodopa?

Since levodopa metabolism has been associated with reactive oxygen species [15, 16], findings in the study offer a novel option for use in integrative medicine i. e. use of levodopa and propolis to minimize on the side effects of levodopa therapy.

After taking levodopa for some time, typically a few years, patients may begin to experience a wearing off period, when symptoms return before it's time for their next dose of levodopa. This is also referred to as "off time.”

It is reassuring that early levodopa initiation and appropriately maximal tolerated dose do not appear to predispose to major, disabling dyskinesia.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329327/?fbclid=IwAR3cBU8HRtHndGoqLJ_X9x2nhr7o1_tKnx8w0L1saK_oSy0C7i1kh1bCxdI#!po=0.862069

Is it too much or too little levodopa?

In this 2021 study they showed through fecal DNA of 107 PwP that levodopa and especially Levodopa/Carbidopa Intestinal Gel (LCIG) are associated with an inflammatory microbiome.

"Or" maybe it flushed out the bacteria eating your Levodopa - Like when I was on antibiotics and didn’t need any L-dopa for a month (didn't/haven't got up to previous dose).

“Each capsule contains 350 mg of extract of the Mucuna pruriens seed in a concentration of 15%, which is 50 mg of natural levodopa (equivalent to the synthetic levodopa in half a tablet of Sinemet Plus or one fifth of Sinemet 250). “ Any feedback is appreciated.

Abbvie’s subcutaneous, pump-delivered levodopa-carbidopa formulation ABBV-951 scores a goal in Phase III for #Parkinsons; A 2.7-hour increase in “On” time; Planned approval filings.

Perhaps you saw Jim's recent excellent post "The Value Of Carbidopa Levodopa Demonstrated in Two Signatures" at https://healthunlocked.com/cure-parkinsons/posts/146518581/the-value-of-carbidopa-levodopa-demonstrated-in-two-signatures How has carbidopa/levodopa helped you?

It aims to enroll 40 patients, ages 30 to 75, who are taking levodopa at 400 mg or more daily but have a history of motor fluctuations and “reliable” early morning “off” periods — a state in which levodopa is no longer working and symptoms, such as tremors, rigidity, and slow movement, are re-emerging

Let us consider the fact that many Parkinson's patients use levodopa, and the more severe the Parkinson's the more levodopa is used. Protein interferes with absorption of levodopa, so patients using levodopa tend to avoid ingesting protein at the same time.

'On time' from levodopa has decreased. I'm having much trouble walking. There have been no other supplements added during this time. Does this sound familiar to those who have tried the HDT with this form of thiamine?

My Dose Carbidopa levodopa IR 25/100 (2) Thiamine hcl 4 grams daily. Tentatively Carbidopa levodopa IR 25/100 (1) Thiamine hcl 6 grams daily.

So during the day in addition to his levodopa 100/25, 3 times per day, he takes 40mg of propranolol which relieves tremor, and 150mg of Venlafaxine for anxiety twice per day.

My Dad is currently on natural levadopa as he doesn’t like the thought of western medicine. He watched his brother suffer terribly with western medicine. Is this still beneficial with Thiamine therapy?