Lithium with Rasagiline?: Dear all, I am... - Cure Parkinson's

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Lithium with Rasagiline?

MAJ88 profile image
20 Replies

Dear all,

I am reading about the benefits of Lithium for the brain and I am thinking of trying it.

However, I am concerned about it’s tolerability with 1mg Rasagiline. Does anyone have any experience with this or recommendations?

Many thanks! Stay strong!

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MAJ88
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PDTom profile image
PDTom

look here:

michael-nehls.com/infos/faq/

michael-nehls.com/

MAJ88 profile image
MAJ88 in reply toPDTom

Thank you Tom! Nehls is a great guy and I think it sounds reasonable to me what he is saying. However, I don’t see that he mentions the interaction of Lithium with Rasagiline, which ChatGPT warns against? I guess I would have to stop taking Rasagiline?

park_bear profile image
park_bear in reply toMAJ88

Large language model chatbots like chat GPT are not intelligent and are not a valid source of health information. They are best avoided. Drugs.com has got a good interactions checker: drugs.com/interactions-chec...

See my post: Using "AI" for research yields wrong answers. Often. Here: tinyurl.com/uzaa9wkn

MAJ88 profile image
MAJ88 in reply topark_bear

Thank you very much!

LAJ12345 profile image
LAJ12345

lithium is like a nutrient so it is to replace a deficiency. Rasagaline is a synthetic drug. I suppose lithium might reduce the amount of a drug required if that he deficiency was causing your problem otherwise I think they would be ok together, doing different things? Thoughts anyone?

MarionP profile image
MarionP in reply toLAJ12345

Smaller doses of lithium, those which our packaged with the supplement lithium rotate, do help moods so just lithium orotate is the version you get without a prescription and that level of dosing is often helpful, far far smaller doses than the prescription lithium which is for addressing actual serious mental illness. Whether, or how, lithium might interact with a dopamine treatment, couldn't say.

MAJ88 profile image
MAJ88 in reply toMarionP

Thank you very much!

00Mark profile image
00Mark

I understand lithium is used to treat bipolar disorder, but that it's potentially toxic, so approach with caution.

MAJ88 profile image
MAJ88 in reply to00Mark

Thank you, you are right. It should be carefully “micro dosed”, I am told.

MarionP profile image
MarionP in reply to00Mark

That concern is only with the far far stronger doses of lithium one can only get with a prescription, labeled for bipolar and severe depression. Comparatively, the over-the-counter lithium orotate is a very very small amount, doctor. See MarkPrama comment for a bit moreon the OTC.

MarkPrana profile image
MarkPrana

I've been using low dose lithium for over a year alongside rasagiline.

Low dose = 20mg-30mg, which is WAY below the dose useful to treat bi-polar disorder.

I believe there is some potential impact on thyroid function, so have been taking under supervision of my neurologist (although I buy as an OTC supplement i.e. not on prescription).

Why? Lithium is a promising treatment for PD that is currently receiving financial support from Cure Parkinson's. They are quite rigorous in choosing the potential treatments they select to invest in.

Thomas Gattuso's book on Amazon, The Promise of Lithium, gives a good overview of the rationale and research foundations to date.

Side Effects? As outlined in Gattuso's book, a touch of 'brain fog' is a potential side affect that can be reduced by lowering the dose.

I started on 30mg/day and felt I did notice a slight reduction in my mental sharpness. I've since reduced the dose to 20mg/day and the slight brain fog i was experiencing has disappeared.

Hope this helps.

Biscuit61 profile image
Biscuit61 in reply toMarkPrana

I had read about the benefits of lithium and my PWP takes 10mg a day - am wondering now if more benefit to increase to 20mg…

MarionP profile image
MarionP in reply toMarkPrana

Good comment mark, you helped counter a little bit of misinformation above. And yes really MAJ, chat GPT is definitely worth exactly what you paid for it, like a blind person asking somebody on the street: always use it only as a starting point with much suspicion.

MAJ88 profile image
MAJ88 in reply toMarionP

Will do. And - we have each other here!

MAJ88 profile image
MAJ88

Thank you so much, this is really helpful! My functional medicine doctor recommended to start with 5mg per day. Can’t wait for my delivery! Happy weekend!

renglaji12 profile image
renglaji12

To those of you using low dose lithium, which version are you taking? Lithium orotate or lithium aspartate?

Biscuit61 profile image
Biscuit61 in reply torenglaji12

It was lithium orotate that I saw on the study so that’s what my PWP takes 10 mg daily

MarionP profile image
MarionP in reply torenglaji12

That's a good question and you know I have never seen lithium aspartate used in a study or even heard of it so it may be more rare and much less studied. But aspartate itself is just another absorption aid, like hcl, your body already produces aspartate but in sweeteners aspartate can act like a sugar and neural stimulant and it makes me break out and intensely itch like crazy, only stops after a couple hours of antihistamine, so I avoid aspartate and aspartame in anything that goes in my mouth.

carrow_road profile image
carrow_road

i have been taking Lithium Orotate for at least 6 months alonside rasagiline. I started with 5 mg and ramped up to 2x10 mg with no negative effect. I noted mood improvement and less (close to none) panic attacks since on 20 mg.

MAJ88 profile image
MAJ88 in reply tocarrow_road

Thank you! That’s very helpful, as I am currently experiencing bouts of anxiety attacks.

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