I have been putting together a really strong drink. I guess it's about $15 a day, with most of the cost being in the powder extracts, $2 to $3 per day each, straight from China in bulk.
12 oz pomegranate juice from Hispanic store (not the expensive POM)
added sweet concentrates:
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black cherry concentrate 12 g
black molasses 12 g (sugar cane juice after most of the white sugar is removed)
Jallab 12 g (Arabic grape skin extract plus others)
powder 10:1 extracts:
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blueberry extract 12 g (my eyesight sharpened enough to not need my barely-needed glasses in 4 days)
strawberry extract 12 g
apple peel extract 12 g
tangerine peel extract 12 g
Citrus flavonoids with animal studies in PD, bought from china in bulk.
These doses are 1/4 the human-equivalent doses because the studies are "shock" studies on the animals by which I mean they are very short term to see how the chemicals work in response to PD-like toxin challenges.
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nobiletin 500 mg
naringin 300 mg
tangeretin 100 mg
Other stuff in pills with strong animal and epidemiological evidence for PD and ability to absorb and cross blood brain barrier (pills not in the drink):
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black tea extract
green tea extract
grape seed extract
fisetin
(inosine to be added)
The American producer of patented fisetin is not clear that it is pure fisetin and the brand is hiding details about what it is, exactly, so I'll spend 1/3 as much to get pure fisetin from China and then sell the excess on ebay. Inosine in bulk is also 1/3 the cost from china.
Canola mayonnaise, the bomb!
Broccoli, Sardines, home-made very yeasty beer, olive oil
1 hour exercise, then drink it to absorb the sugar.
Written by
zawy
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While i applaud your efforts, I am not sure I trust the Chinese stuff to be 100% pure. I have purchased items from China and found them to be not as advertised. Be wary of any unregulated products you buy. Are there any essential oils you can buy that are equivalent to what you are using? I am a firm believer in Essential Oils. Just be sure you buy those that are Pharmaceutical grade.
Right, I have no promise of quality like I could from a trusted American brand who knows their Chinese suppliers and checks the quality. The best I can do is buy an American brand and compare color and bitterness, which is really a good test. The bitterness of the 3 select flavonoids I listed is very strong and distinct. The naringin tastes like the STRONG part of grapefruit juice, so I'm sure it's there. The price is already high and I'm sure oils will be more expensive. The flavonoids I'm targeting should be fine in powder form and survive typical extraction methods. I do not know if they come out in the oils.
Something I'm doing is working great. It's the heavy exercise, canola oil-based mayonnaise, this cocktail, or the combination. It's going to take months of observation and experimentation to determine what's working the most.
I'm SOOOOO happy to see our friendly online shaman has been busy at his cauldron there in Zawy's Magical Kitchen brewing up yet another magical mystical potion for his fans!!! Now we finally have a drink to chase down his fantabulous "1 part bread to 2 parts mayonnaise" prescription - HOORAY!!. If the wondrous shaman continues to stir up his fantastical elixirs (a.k.a. whacky concoctions) the Nobel Prize certainly awaits!!! (not)
Which further confirms your complete ignorance of LEGITIMATE neuroprotective compounds vs the nonsensical voodoo concoctions brewed up in Zawy's Magical Kitchen (but, you're still entertaining - keep stirring your potions!)
YAY! I can hardly contain my excitement!!! A bumpkin wanna-be witch doctor is going to show me what is wrong with scholarly studies from UCLA, NIH, and others in regards to tumeric/curcumin and, specifically, the improved bioavailability of the longvida formulation (you are a natural born entertainer!).
I suspect this is merely a blatant attempt to promote Zawy's Magical Kitchen and your famous '1 part bread 2 parts mayonnaise' concoction... nevertheless, I anxiously await your unveiling of the diabolical scam behind the longvida formulation of curcumin.
To get you started NIH/PubMed has a chart of the numerous reformulations of curcumin to address the bioavailability factor (so you have an idea of the extent of efforts made in this regard): ncbi.nlm.nih.gov/pmc/articl...
NIH/PubMed cites the endless continuum studies over the years confirming the numerous benefits of curcumin in general, and the improved bioavailability of the various 'reformulations' specifically: ncbi.nlm.nih.gov/pmc/articl...
And, specific to 'longvida' formulation (studies from UCLA, Ohio State University, and the 'longvida' fact sheet respectively:
I remain on the edge of my seat as I await the illustrious Shaman Zawy to unleash his brilliance on this quackery and unmask, once and for all, the evil fraud!!!
For your first and second link you neglect to mention the authors' conclusion despite these numerous attempts: "Despite its efficacy and safety, limited curcumin bioavailability continues to be highlighted as a major concern."
I believe UCLA has the longvida formulation patent or otherwise directly funded by longvida, so it's not an unbiased source. They have not made the full report publicly available so they have not provided evidence that it is active in people. (your 4th link). Even worse, they recommend DHA which some research indicates makes PD worse. They are conducting trials in Alzheimer's so maybe in the future they will have evidence. They want you to take 8 pills a day, so a $36 bottle will last 7 days.
Your 3rd link has comments about the general health benefits that might apply just as well to any other forms of curcumin, and still not reach the brain or otherwise affect PD. Vitamin C has similar effects and is a lot cheaper. He is also funded my longvida. That was his only publish paper on curcumin and PD. Most of us have already read more about PD than he has.
Your 5th link is another paid advertisement by longvida directly to their website. I already reviewed their website and could not find anything that indicates it will help PD any more than any other supplement.
This addresses all your links to each of the longvida profiteers that have no evidence curcumin is bioavailable in humans not too mention useful in PD. You forgot the Australian study that was horribly done and again funded by longvida. They are more shameless and less regulated than pharmaceuticals.
I took your original longvida recommendation seriously and investigated it thoroughly only to come up empty-handed.
Wowie Zawy! You promised to unveil the diabolical longvida "scam" yet you've failed miserably to provide anything but another rambling collection of witless drivel in your frantic efforts to promote Zawy's Magical Kitchen. The ruse is obvious! In order to attract the suffering masses to your magical mystical (and nonsensical) "1 part bread 2 part mayonnaise" concoction, you must first discredit more viable remedies.
When you attached the word "scam" to 'longvida' (a bioavailable reformulation of the proven neuroprotectant curcumin), and then promised to expose "what's wrong" with it, I expected that a dazzling display of scholarly brilliance would be forthcoming.
Instead, however, what we find in your response is merely a sad display of incoherent, juvenile petulance. You display an enormous talent for spewing volumes of childish gibberish - all peppered with the occasional clinical term in an amateurish attempt to add credibility - but zero concrete evidence to support your presumptions. Nowhere in your entire text of meandering blather and lofty claims is a single hint of credible science to back your claims of fraud.
Now, the question remains: (without further blather-flows) where can we find a single scientific source of evidence to support your dubious claims of "scam" (a double-dose of your magical '1 part bread 2 parts mayonnaise' formula may help your reply)? Still awaiting a LUCID response...
Your only response is to ridicule the messenger? You don't have any information to defend the advertising efforts of longvida that act under the guise of science? You're still going to pay $5 a day for literally $0.02 worth of micronized curcumin cooked in oil? If longvida makes it 70 times more bioavailable, then what not take 70 times straight curcumin at 1/4 the cost? Or better yet, cook it in a turmeric meal and get maybe 20 times more curcumin than longvida at 1/4 the cost. Why should I bother giving you another response if you only want to ridicule me?
It's heartbreaking to have to break the tragic news, Zawy, but you're clearly displaying the telltale signs of late stage dementia. Your bizarre replies show only fractured connection to the original subject of our exchange and absolutely no recollection whatsoever of the fact that it was YOU, Shaman Zawy of Zawy's Magical Kitchen fame, that promised to expose the "scam" of any links posted.
Your original promise remains unfulfilled: "Post links to any research paper to it and I'll show you what's wrong."
Does that spark your memory... can you guess the author?
Yet now, like a tottering geriatric who's mind has reverted to some distant point in early adolescence, you ask ME to defend the very subject that you yourself have leveled the charges of fraud against. Apparently the contradiction escapes you.
I'm very worried for you. I hope you have assistance to keep your disposables changed and someone to steer you through the course of your daily routine.
Try not to regret your inability to maintain a train of thought for more than a minute or two, nor your inability to follow through on your promises - it's an unfortunate yet understandable consequence of senility. Best of luck!
Apparently we simply disagree as to what constitutes evidence. For me, a single abstract from the patent holder (UCLA) is not enough.
You might be interested to know that the U.S. government, through the department of veteran's affairs who apparently funded UCLA owns the patent and that only longvida has permission to use it.
If longvida is coupling curcumin with DHA (like the patent mentions in one embodiment) in order to target cancer and Alzheimer's, then it could make PD cases worse since DHA causes the mis-folding a-syn protein to spread. Only 1 of their 6 formulation possibilities in the patent do not contain DHA.
The patent gives many options for making your own absorbable curcumin (consume half as tetrahydrocurcumin, mix it with vitamin C, olive oil, and peperine). They do not like peperine only because it may interfere with other drugs people are taking as stated in the patent, not because it does not help. They state tetrahydrocurcumin is 6 to 7 times better absorbed as curcumin by itself, and synergizes with regular curcumin.
They state "Our data shows that when curcumin is dissolved in oil, plasma curcumin remains low, but red blood cell curcumin is quite high, which explains bioavailability despite negligible plasma levels. No other group has reported this fundamental observation that appears to be the simplest method of enhancing bioavailability. " Notice that do not say it requires any special formulation, just curcumin and oil, like in an Indian meal.
So it might be that special formulations are not needed at all: just mix with oil and it has always been there in people's red blood cells and researchers just couldn't see it. So now I might be changing my mind about curcumin (not longvida) afterall. Like I said, it's half price to take 70 times more curcumin than longvida contains in order to get a stronger dose, but if the primary delivery is through red blood cells, then longvida is no better than curcumin mixed with oil by the patent holder's own statements.
Filing a freedom-of-information act request through the government's website might obtain the exact formulation longvida is using and get the full UCLA paper for free, not to mention all the emails between UCLA and verdue sciences (longvida).
What do you call it when the department of veterans affairs finances, patents, and licenses an idea that results in people paying $10 a gram for ingredients that cost $0.02 ?
Judging by the enormous volume of mindless, nonsensical crap that continues to spew forth onto the pages of the forum here (now with random links tossed in along with the occasional medical term in your futile efforts to appear intelligent), I can only suggest that your care assistant increase the frequency by which they empty your disposables. We need to keep all that crap away from here...
I just started it, so I have no idea, except the 25% proanthocyanodins blueberry extract is awesome, giving me much better vision. There's a clock at the pool that I previously could barely read at 30 feet, and now after about 10 doses I can read it sharply at 50 feet. Only the strawberry and apples are in epidemiological studies for men with 20% protection each, and the grape, green tea, and black tea are in epidemiological studies for both, and there are animal studies in the others with some evidence they can reach the brain. So far in terms of experience I am only completely sure about exercise.
I think you need to be wary of pomegranates and PD.
Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.
Tapias V1, Cannon JR2, Greenamyre JT3.
Author information
Abstract
Numerous factors contribute to the death of substantia nigra (SN) dopamine (DA) neurons in Parkinson's disease (PD). Compelling evidence implicates mitochondrial deficiency, oxidative stress, and inflammation as important pathogenic factors in PD. Chronic exposure of rats to rotenone causes a PD-like syndrome, in part by causing oxidative damage and inflammation in substantia nigra. Pomegranate juice (PJ) has the greatest composite antioxidant potency index among beverages, and it has been demonstrated to have protective effects in a transgenic model of Alzheimer's disease. The present study was designed to examine the potential neuroprotective effects of PJ in the rotenone model of PD. Oral administration of PJ did not mitigate or prevent experimental PD but instead increased nigrostriatal terminal depletion, DA neuron loss, the inflammatory response, and caspase activation, thereby heightening neurodegeneration. The mechanisms underlying this effect are uncertain, but the finding that PJ per se enhanced nitrotyrosine, inducible nitric oxide synthase, and activated caspase-3 expression in nigral DA neurons is consistent with its potential pro-oxidant activity.
I’m no scientist, but my hugely uninformed guess is that large amounts of pomegranate juice are harmful simply due to the natural sugar content. I hope that I’m right because I love pomegranate seeds and buy the fruit in season. I eat the seeds, not just the juice, thus getting the fiber.
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