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Thyroid UK
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Hi All, any help please, I have been on 100 levo for two weeks (previously 125) in preperation to start my T3 T4 combo, advise on how I should start, my Endo suggests 5 micrograms of liothyronine twice daily + 50 mcg levothyroxine once a day been advised that this is much to low, this is my latest blood results:-


CRP 3.10 <5.0 mg/L

Ferritin H 323.1 20 - 150 ug/L

Thyroid Function

TSH L 0.16 0.27 - 4.20 IU/L

T4 Total 107.8 64.5 - 142.0 nmol/L

Free T4 17.23 12 - 22 pmol/L

Free T3 3.85 3.1 - 6.8 pmol/L


Anti-Thyroidperoxidase abs H 154.8 <34 kIU/L

Anti-Thyroglobulin Abs 17.1 <115 kU/L


Vitamin D (25 OH) 72 Deficient <25 nmol/L

Insufficient 25 - 50

Consider reducing dose >175

Vitamin B12 405 Deficient <140 pmol/L

Insufficient 140 - 250

Consider reducing dose >725

Serum Folate 23.41 10.4 - 42.4 nmol/L

Cortisol (morning) 253 nmol/L with an ACTH of 21 ng/L

Corrected calcium was 2.3 with a PTH of 56

BLOOD TEST FEB 2012 on 25mcg Thyroxin

TSH Level 2.96 miu/L (0.27-4.20

T3 Level 4.3 pmol/L (3.1-6.8)

Serum cholesterol 6.8 mmol/L

Anti-TPO Antibodies 820 U/ml (0-150) HIGH will be filed as 43Gd.00 Thyroid peroxidase

antibody level 820 u/mL

Anti-Thyroglobulin Abs 13 U/ml (0 - 150) will be filed as 43G5.00 Thyroid autoantibodies 13 u/mL

Serum vitamin B12 436 ng/l (187-883) will be filed as 436 ng/L

6 Replies


FT4 17.23 is mid-range and FT3 is low in range so I wouldn't reduce dose and would add 2 x 5mcg T3 to 100mcg Levothyroxine. TSH is low and will almost certainly become suppressed by adding T3.

Thyroid peroxidase antibodies are positive for autoimmune thyroid disease (Hashimoto's) which causes 90% of hypothyroidism in the UK, Europe, USA and Canada. 100% gluten-free diet may improve symptoms and reduce antibodies.



If you are able to get sun on your face and arms a few hours per week there is no need to supplement vitamin D until October.

B12 is optimal around 1,000 so supplement 1,000mcg methylcobalamin and take a B Complex vitamin too.

Folate is fine.

I can't interpret results without ranges but calcium 2.3 is usually within range so there is unlikely to be a hypo or hyperparathyroidism.


I am not a medical professional and this information is not intended to be a substitute for medical guidance from your own doctor. Please check with your personal physician before applying any of these suggestions.


Hi Clutter Thank you, I have been doing as you say for the past three days (sourced my own T3), haven't noticed any improvement apart from heat rush just after taking, how long should I stay on this dose? I have been taking B12 + B complex for the past two weeks + Magnesium and Selenium. I will look into Gluten free. since droping to 100 levo I have put back on the little bit of weight I had lost, when I drop from 125 to 100 my hair starts to fall out and I gain weight. When should I start to feel any improvement. I have appointment with Dr in 3 weeks time I know after all that has gone on with the T3 debate he won't let me have any.



10mcg Liothyronine (T3) is equivalent to 30mcg Levothyroxine so hopefully the combined dose equivalent to 130mcg Levothyroxine will be fine for your hair and weight.

It takes 3-3.5 days to get into the cells so you may start feeling some improvement any time now but it will take a few weeks for FT3 level to build up. Most people will feel well when FT3 is >5.0.



Should I continue to split dose I take 5 + thyroxine early morning then the other 5 in the afternoon. Thanks for the links, are you gluton free if so did you find it hard ?



I'd certainly continue to split dose for a few weeks. You might want to try 1 x 10mcg after that.

I'm not gluten-free. I would have tried it to see if symptoms improved but wasn't aware of it at the time. Subsequent to thyroidectomy and RAI I no long have Hashimoto's and haven't any need to try g-f.


Thanks for prompt reply I will do as you say, lets hope I see an improvement in my symptoms.


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