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Not great news for hubby today. What is next?
Just updated my husband's profile so you can see his journey from 2016. Oncologist today said to continue the Abiraterone for another month and see where we are at with PSA results. Was up again today. He did have 6 rounds of targeted radiation last month, so would that cause PSA to go up. We were hoping
Just updated my husband's profile so you can see his journey from 2016. Oncologist today said to continue the Abiraterone for another month and see where we are at with PSA results. Was up again today. He did have 6 rounds of targeted radiation last month, so would that cause PSA to go up. We were hoping
Docker53
in
Advanced Prostate Cancer
13 days ago
My experience with Docetaxel
I know everyone doesn’t respond the same but here is my experience and what I went through with 10 rounds of chemo. Before I started I had already been on Lupron for five years, I had radiation to multiple bone Mets, took zytiga/xtandi, had Provenge and did a clinical trial. October 26 2023 I started
I know everyone doesn’t respond the same but here is my experience and what I went through with 10 rounds of chemo. Before I started I had already been on Lupron for five years, I had radiation to multiple bone Mets, took zytiga/xtandi, had Provenge and did a clinical trial. October 26 2023 I started
Oct18
in
Advanced Prostate Cancer
14 days ago
What comes after, what comes next?
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
lgutman
in
Advanced Prostate Cancer
14 days ago
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Phase 1 trial shows promising results for fractionated dose of 225Ac-J591 in PCa treatment
The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good! https://www.urotoday.com/conference-highlights
The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good! https://www.urotoday.com/conference-highlights
Maxone73
in
Advanced Prostate Cancer
15 days ago
177Lu-PSMA-617: Trial shows it's more effective than changing ARPIs
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
Maxone73
in
Advanced Prostate Cancer
15 days ago
225Ac-J591 Yields Responses in Difficult-to-Treat Metastatic Prostate Cancer
It seems to work better on visceral and bone metastatis... https://www.cancertherapyadvisor.com/home/news/conference-coverage/suo-2023/225ac-j591-yields-responses-in-difficult-to-treat-metastatic-prostate-cancer/
It seems to work better on visceral and bone metastatis... https://www.cancertherapyadvisor.com/home/news/conference-coverage/suo-2023/225ac-j591-yields-responses-in-difficult-to-treat-metastatic-prostate-cancer/
Maxone73
in
Advanced Prostate Cancer
6 months ago
Rising PSA
Year 7… No prostate. Clear everything in 2017 … but 6 months after surgery rising PSA. Casodex/Lupron/39 Rounds Radiation. Presently on Lupron/Nubeqa PSA rising PSMA Scan Clear CT scan with Contrast today plus Fractionated Blood Biopsy. PSA 10.8 Waiting on CT results but Dr. Aggarwal wants
Year 7… No prostate. Clear everything in 2017 … but 6 months after surgery rising PSA. Casodex/Lupron/39 Rounds Radiation. Presently on Lupron/Nubeqa PSA rising PSMA Scan Clear CT scan with Contrast today plus Fractionated Blood Biopsy. PSA 10.8 Waiting on CT results but Dr. Aggarwal wants
JolleySprings
in
Advanced Prostate Cancer
3 months ago
Recurrence after prostatectomy
I have a relative who had surgery 6.5 years ago. Pathology was very favorable, 3+3+tertiary 4 i.e. less than 5%, no pos margins, no ECE, no nodes. He remained undetectable for 6.5 years, but now is .07 verified. What would SOC be for him? Prostate bed or wide radiation, length of ADT, just Lupron or
I have a relative who had surgery 6.5 years ago. Pathology was very favorable, 3+3+tertiary 4 i.e. less than 5%, no pos margins, no ECE, no nodes. He remained undetectable for 6.5 years, but now is .07 verified. What would SOC be for him? Prostate bed or wide radiation, length of ADT, just Lupron or
Fred312
in
Advanced Prostate Cancer
6 months ago
radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
16 days ago
radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
16 days ago
Advice - Surgery or Radiation?
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Blue1320
in
Prostate Cancer Network
16 days ago
Rising PSA on ADT
Prostatectomy 2015, Gleason 4 + 3. 31 external radiation tx, ADT (Zoladex) 2015-17, post nadir Oct 2017 rising PSA until Jan 2022. Degarelix for 8 months. Two months after end of Degarelix PSA rising rapidly (doubling time 5 weeks). Started ADT (Zoladex) Feb 2023. By Oct PSA 0.40 ug/L, Dec 0.43 ug
Prostatectomy 2015, Gleason 4 + 3. 31 external radiation tx, ADT (Zoladex) 2015-17, post nadir Oct 2017 rising PSA until Jan 2022. Degarelix for 8 months. Two months after end of Degarelix PSA rising rapidly (doubling time 5 weeks). Started ADT (Zoladex) Feb 2023. By Oct PSA 0.40 ug/L, Dec 0.43 ug
MGBman
in
Advanced Prostate Cancer
3 months ago
Xofigo anyone?
So my PSA is rising after Chemo, Lupron and NUBEQA (Darolutamide). It rose from 0.04 in June 2023 to 0.84 at the end on April 2024 with latest time of doubling about 5 weeks, 2.3 years after diagnosis. I don't have organ on lymph node metastasis yet. My oncologists team suggests Xofigo/Ra-223 as a next
So my PSA is rising after Chemo, Lupron and NUBEQA (Darolutamide). It rose from 0.04 in June 2023 to 0.84 at the end on April 2024 with latest time of doubling about 5 weeks, 2.3 years after diagnosis. I don't have organ on lymph node metastasis yet. My oncologists team suggests Xofigo/Ra-223 as a next
Oldie68
in
Advanced Prostate Cancer
18 days ago
Almost 3 years on ADT + Erleada
I am almost 3 years on ADT I was diagnosed as stage 4 with a bone biopsy on a lesion.My MO started me with monthly firmagon injections and zytiga in 2021 july then switched to lupron and Erleada after a few months since I had a reaction to Abi after a couple of months .Erleada also gave me rash in
I am almost 3 years on ADT I was diagnosed as stage 4 with a bone biopsy on a lesion.My MO started me with monthly firmagon injections and zytiga in 2021 july then switched to lupron and Erleada after a few months since I had a reaction to Abi after a couple of months .Erleada also gave me rash in
mynacho
in
Advanced Prostate Cancer
18 days ago
Brachyboost and PSA progression free survival question
We just received our appointment summary from the radiation oncologist and there is a comment in it that is confusing me. It’s not how I remember the conversation, so I am wondering if someone can clarify ( Tall_Allen ?). ”We can proceed with EBRT followed by LDR brachytherapy boost and minimum 6 months
We just received our appointment summary from the radiation oncologist and there is a comment in it that is confusing me. It’s not how I remember the conversation, so I am wondering if someone can clarify ( Tall_Allen ?). ”We can proceed with EBRT followed by LDR brachytherapy boost and minimum 6 months
EvFC
in
Advanced Prostate Cancer
18 days ago
Pet Scan Below, Does Non Avid PSMA Liver Lesions mean possible Neuroendocrine Cancer
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
Shorehousejam
in
Advanced Prostate Cancer
19 days ago
PSA test
my husband had a PSA done and it raised from 0,5 to 0,7. He finished proton radiation las year January, the PSA went down to 0,5. is this normal, or should he take any action? He will be 81 years old this coming September, would it be okay to let it go. Has anybody have this experience? Thank you for
my husband had a PSA done and it raised from 0,5 to 0,7. He finished proton radiation las year January, the PSA went down to 0,5. is this normal, or should he take any action? He will be 81 years old this coming September, would it be okay to let it go. Has anybody have this experience? Thank you for
Grommi
in
Advanced Prostate Cancer
19 days ago
Should go into the OMAHA2a ODM-208 (MK-5684-004): phase 3 trial?
I had my 3 monthly OC visit last week. Blood test is showing 0.3 up from 0.15 six weeks ago. MO is suggesting that I should go into the ODM-208 (MK-5684): phase 3 trial if PSA rises above 1.0. PSA of 1.0 or above is a entry requirement for the trial, presumable to be sure that my current treatment
I had my 3 monthly OC visit last week. Blood test is showing 0.3 up from 0.15 six weeks ago. MO is suggesting that I should go into the ODM-208 (MK-5684): phase 3 trial if PSA rises above 1.0. PSA of 1.0 or above is a entry requirement for the trial, presumable to be sure that my current treatment
LakeT
in
Advanced Prostate Cancer
19 days ago
Proteolysis-Targeting Chimeras (PROTACs): targeting cancer by deleting deleterious proteins?
There seem to be a kind of superiority of PROTACs over conventional inhibitors in treating prostate cancer. The article examines various targets for PROTACs in prostate cancer, including the androgen receptor and other critical oncoproteins, while addressing future prospects and challenges in this
There seem to be a kind of superiority of PROTACs over conventional inhibitors in treating prostate cancer. The article examines various targets for PROTACs in prostate cancer, including the androgen receptor and other critical oncoproteins, while addressing future prospects and challenges in this
Maxone73
in
Advanced Prostate Cancer
6 months ago
Had Pet Scan, PSA rising 0.77 Found Liver Metastases, Am I a dead man? What can I do?
Going for MRI and Biopsy What can I do?
Going for MRI and Biopsy What can I do?
Shorehousejam
in
Advanced Prostate Cancer
20 days ago
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