PSA still undetectable and testosterone doubles to 1.6

[Brysonal]

Just an update as I yesterday was blood test day.

I’m continuing with the Apalutamide monotherapy, still enjoying working full time and just back from an Italian lake holiday.

So no movement on my PSA but interesting to see testosterone creeping up ( 11 months since my last Zoledex injection so 8 months from the first missed ADT injection).

Not noticing major impact from having a little bit of testosterone but carrying on with this pathway building up to potential chat about dropping Apalutamide..

Appreciate in December 20 I had bone mets popping up everywhere pre all my treatments so Soc is ADT for life but my treatment pathway wasn’t Soc ( early Lu-177 x 3 plus 3 Docetaxel, 20 Vmat sessions. 2 brachitherapy. 3 SBRT to more stubborn mets and the OVM 200 vaccine on trial). I of course had ADT throughout this period and subsequently did ADT and Apalutamide for a year so who knows what’s going on wit my PCa but for now scans are clear and I really did want to try without the injections .

So another testing day, another undetectable .. maybe all down to the Apalutamide of course.

Hope you guys are all well

[Maxone73]

really unusual path, but I am glad it's working...but my concern is: which italian lake?

[Brysonal in reply to Maxone73]

Lake Garda for a week following 2 nights in Verona

[Maxone73 in reply to Brysonal]

drop me a message next time!

[Brysonal in reply to Maxone73]

Ah - is that where you live - it was beautiful!

[Maxone73 in reply to Brysonal]

I was born and lived for a long time 10 minutes from Lazise (in the middle between the lake and Verona) and now I live in a different place...that is still 20 minutes from Peschiera anyway

[GreenStreet]

Thanks for the update. Glad it is going well for you. You deserve it

[Justfor_]

Testosterone is in nmol/L?

[Brysonal in reply to Justfor_]

It is

[Justfor_ in reply to Brysonal]

That is good. You are a tad bellow the castration cutoff point, i.e. 46 < 50 ng/dL. Very shortly you will get better visibility. All the best to you.

[Brysonal in reply to Justfor_]

Thanks for confirming, here in UK they do nmol/L.

I guess next tests may see a rise in PSA if my T continues to rise?

[Justfor_ in reply to Brysonal]

Let's hope it doesn't and in the event it does, it will plateau somewhere very low. But, my gestimate is that as long as you are taking ARPI it will not.

[Brysonal in reply to Justfor_]

Fingers crossed

[Nugger]

Great to hear a UK guy that's giving it,all he's got 👍

[Brysonal]

Thanks Nugger. I had to travel to Helsinki for the Lu-177 and then chose to do the Docetaxel and Vmat there as I knew them by then. They also did the brachys ( which my London MO was not happy about!). Monitored and meds in London with OVM 200 clinical trial out of UCLH. UK based but if it’s not available here prepared to travel!

[KocoPr]

Awesome news! Can you get darolutamide? Since you are not taking ADT and your T is climbing why not let your brain enjoy some T conversion to estrogen? Apalutamide and Enza both cross the BBB but daro has near zero penetration.

As we certainly know estrogen is crucial in the brain for mental health.

ncbi.nlm.nih.gov/pmc/articl....

[fast_eddie in reply to KocoPr]

I learn something new every day on this site. Thanks.

[NPfisherman]

Thanks for sharing your results. Great news... Here's hoping that things continue smoothly on your journey... On OVM-200, did they look at your wbc count post vaccine or for increased T cell clonicity in response to the vaccine??