I’m continuing with the Apalutamide monotherapy, still enjoying working full time and just back from an Italian lake holiday.
So no movement on my PSA but interesting to see testosterone creeping up ( 11 months since my last Zoledex injection so 8 months from the first missed ADT injection).
Not noticing major impact from having a little bit of testosterone but carrying on with this pathway building up to potential chat about dropping Apalutamide..
Appreciate in December 20 I had bone mets popping up everywhere pre all my treatments so Soc is ADT for life but my treatment pathway wasn’t Soc ( early Lu-177 x 3 plus 3 Docetaxel, 20 Vmat sessions. 2 brachitherapy. 3 SBRT to more stubborn mets and the OVM 200 vaccine on trial). I of course had ADT throughout this period and subsequently did ADT and Apalutamide for a year so who knows what’s going on wit my PCa but for now scans are clear and I really did want to try without the injections .
So another testing day, another undetectable .. maybe all down to the Apalutamide of course.
Hope you guys are all well
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Brysonal
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I was born and lived for a long time 10 minutes from Lazise (in the middle between the lake and Verona) and now I live in a different place...that is still 20 minutes from Peschiera anyway
Let's hope it doesn't and in the event it does, it will plateau somewhere very low. But, my gestimate is that as long as you are taking ARPI it will not.
Thanks Nugger. I had to travel to Helsinki for the Lu-177 and then chose to do the Docetaxel and Vmat there as I knew them by then. They also did the brachys ( which my London MO was not happy about!). Monitored and meds in London with OVM 200 clinical trial out of UCLH. UK based but if it’s not available here prepared to travel!
Awesome news! Can you get darolutamide? Since you are not taking ADT and your T is climbing why not let your brain enjoy some T conversion to estrogen? Apalutamide and Enza both cross the BBB but daro has near zero penetration.
As we certainly know estrogen is crucial in the brain for mental health.
I asked the question in my MO consult and hes fine if i want to switch. I have a relatively current stack of apalutamide to finish but will try darolutamide for next prescription. I am starting to feel more normal tbh
Thanks for sharing your results. Great news... Here's hoping that things continue smoothly on your journey... On OVM-200, did they look at your wbc count post vaccine or for increased T cell clonicity in response to the vaccine??
Will they give it to you at some point?? I guess you will have some idea post study, based on the reported results , of what the odds were that you had a positive reaction...I am keeping well... more testing coming up, but so far, so good...
I can't get any info! If they get funding for phase 2 or indeed scrop it all together i guess they may tell me. In the meantime I guess my own test results may unfortunately tell me at some point it hasn't worked for me so I will continue monitoring!
No information is unfair.... I just don't get what giving you the Elispot results would threaten the integrity of the data...Grateful to be on the Monitoring Train as well...
I haven't switched but my MO retired this month so due a chat with the new guy. No idea what he will think of my none standard story!
So still undetectable PSA and NED on scans. Taking my standard apalutamide still (and tamoxifen due to risk of boobs on monotherapy!)
Still working full time, following my football team at home and in Europe, bring a grandad to a 15 month old and tried paragliding for firsttime in Turkey last month!
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