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AMG 509 (Xaluritamig): update on this immunotherapy for mCRPC
They published the first findings on Cancer Discovery. "Efficacy as measured both by PSA and objective response by RECIST were encouraging in this heavily pretreated mCRPC population, and responses occurred with greater frequency in the higher-dose cohorts. PSA declines were seen starting with 0.1 mg
They published the first findings on Cancer Discovery. "Efficacy as measured both by PSA and objective response by RECIST were encouraging in this heavily pretreated mCRPC population, and responses occurred with greater frequency in the higher-dose cohorts. PSA declines were seen starting with 0.1 mg
Maxone73
in
Advanced Prostate Cancer
6 months ago
Radical prostatectomy consultant in the south of England
I've been diagnosed with prostate cancer, quite aggressive with a Gleason of 9 (4+5). No spread has been detected on a CT scan and I'm due to have a NM bone whole body scan on Friday to detect any spread to the bones. Assuming there is no or little spread, I am keen to have a radical laparoscopic prostatectomy
I've been diagnosed with prostate cancer, quite aggressive with a Gleason of 9 (4+5). No spread has been detected on a CT scan and I'm due to have a NM bone whole body scan on Friday to detect any spread to the bones. Assuming there is no or little spread, I am keen to have a radical laparoscopic prostatectomy
MarkS
in
Prostate Cancer Network
8 months ago
SRBT and EXTEND trial
Does anybody have the full text of EXTEND trial results from June 2023? (my payment attempt is rejected and the tips on how to get a study without cost doesn´t work) https://pubmed.ncbi.nlm.nih.gov/37022702/ Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic
Does anybody have the full text of EXTEND trial results from June 2023? (my payment attempt is rejected and the tips on how to get a study without cost doesn´t work) https://pubmed.ncbi.nlm.nih.gov/37022702/ Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic
Purple-Bike
in
Advanced Prostate Cancer
6 months ago
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Is there any order to when new medications or PARP inhibitor are tried?
My medical oncologist is hell bent on me doing Lu 177 pluvicto next, I was hoping to try other things first… Medical Oncologist suggested waiting for the next two months to see if PSA is still rising…and to do a pet scan Diagnosed 06/2022 Gleason 8/9 Oligo metastatic 3 lytic lesions two resolved
My medical oncologist is hell bent on me doing Lu 177 pluvicto next, I was hoping to try other things first… Medical Oncologist suggested waiting for the next two months to see if PSA is still rising…and to do a pet scan Diagnosed 06/2022 Gleason 8/9 Oligo metastatic 3 lytic lesions two resolved
Shorehousejam
in
Fight Prostate Cancer
6 months ago
Question, each month with rising PSA, when do I do a pet scan
Medical Oncologist suggested waiting for the next two months to see if it’s still rising… Diagnosed 06/2022 Gleason 8/9 Oligo metastatic 3 lytic lesions two resolved Started Firmagon 7/6/2022 Zytiga with Prednisone 7/20/2022 currently still on these meds Docetaxel Chemotherapy on 08/11/2022
Medical Oncologist suggested waiting for the next two months to see if it’s still rising… Diagnosed 06/2022 Gleason 8/9 Oligo metastatic 3 lytic lesions two resolved Started Firmagon 7/6/2022 Zytiga with Prednisone 7/20/2022 currently still on these meds Docetaxel Chemotherapy on 08/11/2022
Shorehousejam
in
Advanced Prostate Cancer
6 months ago
Concern - At 4 mo on Lupron/Abi, Testosterone hits 40
While PSA was again <.1 yesterday, testosterone jumped to 40 ng/dl or 1.4 nmole/L, which is a big move toward the 1.7 danger zone for faster movement toward CRPC ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472467/ ) , and I am interested
While PSA was again <.1 yesterday, testosterone jumped to 40 ng/dl or 1.4 nmole/L, which is a big move toward the 1.7 danger zone for faster movement toward CRPC ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472467/ ) , and I am interested
jackwfrench
in
Advanced Prostate Cancer
6 months ago
Heterogeneity and genomic evolution of metastatic prostate cancer, bioRxiv Preprint, Posted September 04, 2023.
A fine example of evolutionary principles applied to metastatic PCa with the development of a method (Mscore) for risk assessment based on key gene mutations. (U of Texas and Chinese U collaboration.) * * * [i]
Abstract
[/i] [i]
Background
[/i][i] Metastasis is the primary cause of prostate
A fine example of evolutionary principles applied to metastatic PCa with the development of a method (Mscore) for risk assessment based on key gene mutations. (U of Texas and Chinese U collaboration.) * * * [i]
Abstract
[/i] [i]
Background
[/i][i] Metastasis is the primary cause of prostate
CaptnMojoe
in
Fight Prostate Cancer
8 months ago
NY Times Darolutamide Ad
I wonder how much a two-page ad (pages 12-13) in the Sunday edition of the New York Times costs? It begins with a story about Dr. Tom Green, urologist, who has had PCa for 19 years, however, it became metastatic only recently . He has opted for Darolutamide. Segue to Dr. Matthew Smith, lead in
I wonder how much a two-page ad (pages 12-13) in the Sunday edition of the New York Times costs? It begins with a story about Dr. Tom Green, urologist, who has had PCa for 19 years, however, it became metastatic only recently . He has opted for Darolutamide. Segue to Dr. Matthew Smith, lead in
pca2004
in
Fight Prostate Cancer
8 months ago
Statin use and outcomes of oncological treatment for castration-resistant prostate cancer - From the Finnish poulation, Nature, 11/01/23
As a follow-up to recent posts on statins and PCa, here is another Euopean study, this time from the Finns. As noted in the Abstract below, they come to the conclusion of no/little benefit for crPCa, but maybe some for csPCa. The apparent pooling of data for specific type/form of statin does not provide
As a follow-up to recent posts on statins and PCa, here is another Euopean study, this time from the Finns. As noted in the Abstract below, they come to the conclusion of no/little benefit for crPCa, but maybe some for csPCa. The apparent pooling of data for specific type/form of statin does not provide
CaptnMojoe
in
Fight Prostate Cancer
8 months ago
? For fellow BATmen on daro and androgen stimulation. Great Article
I came across this 2023 article and i think it poses a great outcome for us who are cycling high T and darolutamide. Am I correct that this article correlates positively with our BAT with Daro? I find this article extremely fascinating although it is complex. I need to learn more about proteonomic
I came across this 2023 article and i think it poses a great outcome for us who are cycling high T and darolutamide. Am I correct that this article correlates positively with our BAT with Daro? I find this article extremely fascinating although it is complex. I need to learn more about proteonomic
KocoPr
in
Fight Prostate Cancer
8 months ago
RT results look good
After a bout of sepsis from a directed biopsy, 5 weeks of RT and 3 months of Eligard, my tests show undetectable PSA. I'm still dealing with side effects (interrupted sleep, urinary and bowel differences) but happy to report it looks like, for the time being, that my stage 2/3 PC may have been beaten
After a bout of sepsis from a directed biopsy, 5 weeks of RT and 3 months of Eligard, my tests show undetectable PSA. I'm still dealing with side effects (interrupted sleep, urinary and bowel differences) but happy to report it looks like, for the time being, that my stage 2/3 PC may have been beaten
Eadgbe
in
Fight Prostate Cancer
6 months ago
PSA 6 months after RT
Here is a review of a presentationby Dr. Ravi at ASCO 2023, regarding measuring the PSA at 6 months post radiation treatment, for all risk groups. He found that the 6-month post-RT PSA was highly prognostic of 5- and 10-year rates of metastasis free survival (MFS), Overall Survival (OS), and prostate
Here is a review of a presentationby Dr. Ravi at ASCO 2023, regarding measuring the PSA at 6 months post radiation treatment, for all risk groups. He found that the 6-month post-RT PSA was highly prognostic of 5- and 10-year rates of metastasis free survival (MFS), Overall Survival (OS), and prostate
janebob99
in
Prostate Cancer Network
6 months ago
LIQUID BIOPSY: Hello friends, what do you know about Liquid biopsy of circulating tumor ctDNA? Is it usefull with 6.2 PSA ?
Hello friends, what do you know about Liquid biopsy of circulating tumor ctDNA? Is it usefull with 6.2 PSA ? Depending on the results do we get access to some novel drugs like olapariv or nivolumab, etc, that might help us ? 🫠thanks, Manilo.
Hello friends, what do you know about Liquid biopsy of circulating tumor ctDNA? Is it usefull with 6.2 PSA ? Depending on the results do we get access to some novel drugs like olapariv or nivolumab, etc, that might help us ? 🫠thanks, Manilo.
Manilo
in
Advanced Prostate Cancer
6 months ago
Testosterone was nearly back to normal, then dropped
I had a year of Lupron and Enzalutamide in 2022. Testosterone slowly came back to a high of about 240 in June and Sept 2023. Normal for me is around 350 - 375. Now this week T is down to 156. Is this sort of fluctuation normal? I had 6 months of ADT in connection with radiation for recurrent PCa
I had a year of Lupron and Enzalutamide in 2022. Testosterone slowly came back to a high of about 240 in June and Sept 2023. Normal for me is around 350 - 375. Now this week T is down to 156. Is this sort of fluctuation normal? I had 6 months of ADT in connection with radiation for recurrent PCa
Teddy28
in
Advanced Prostate Cancer
6 months ago
EBRT - Is it the right thing and what to expect?
After DX in November 2018 with Stage IV and Gleason of 5+4 and 4+5, and 5 years of ADT of Lupron (then Orgovyx), prednisone 5mg, and Zytiga 250mg with low fat breakfast, my PSA stayed stable at 0.4 or 0.5. At end of 2013, PSA started rising to latest value of 0.84. Had PSMA PET Scan March 5, 2024
After DX in November 2018 with Stage IV and Gleason of 5+4 and 4+5, and 5 years of ADT of Lupron (then Orgovyx), prednisone 5mg, and Zytiga 250mg with low fat breakfast, my PSA stayed stable at 0.4 or 0.5. At end of 2013, PSA started rising to latest value of 0.84. Had PSMA PET Scan March 5, 2024
JazzMan42
in
Advanced Prostate Cancer
3 months ago
Irisin, released from skeletal muscles maybe one of the reasons that exercise is good for prostate cancer patients
The Effect of Irisin on Proliferation, Apoptosis, and Expression of Metastasis Markers in Prostate Cancer Cell Lines Original Research, Open access, Published: 25 April 2022, volume 10, pages 377–388 (2022) Atiye Saeedi Sadr, Hassan Ehteram, Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hassan Hassani
The Effect of Irisin on Proliferation, Apoptosis, and Expression of Metastasis Markers in Prostate Cancer Cell Lines Original Research, Open access, Published: 25 April 2022, volume 10, pages 377–388 (2022) Atiye Saeedi Sadr, Hassan Ehteram, Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hassan Hassani
Graham49
in
Advanced Prostate Cancer
8 months ago
Treatment after Lu /Pluvicto?
It seems that there is paucity of data related to the effectiveness of treatments after Lu/Pluvicto. I'm beginning to suspect that pubished survival benefits for Radium 223/Pluvicto and chemotherapy cannot be assumed to be anticipated if the patient has had Pluvicto. My husband has completed 6 sessions
It seems that there is paucity of data related to the effectiveness of treatments after Lu/Pluvicto. I'm beginning to suspect that pubished survival benefits for Radium 223/Pluvicto and chemotherapy cannot be assumed to be anticipated if the patient has had Pluvicto. My husband has completed 6 sessions
cancervictim
in
Advanced Prostate Cancer
8 months ago
Prostate cancer in liver
Have recently had a PSMA scan. This did show some hot spots for sure. But also, three smaller spots on my liver that did not give off PSMA. Did a liver Biopsy. which is rather painful I might add. Will meet with my 0ncologist on Monday to look at options. Any suggestion for the three rather small spots
Have recently had a PSMA scan. This did show some hot spots for sure. But also, three smaller spots on my liver that did not give off PSMA. Did a liver Biopsy. which is rather painful I might add. Will meet with my 0ncologist on Monday to look at options. Any suggestion for the three rather small spots
Parscore
in
Advanced Prostate Cancer
8 months ago
Declining psa #8
Gm folks, hope all is well during this Christmas season… I’ve just received my 8th psa test after getting off ADT, 9 months of using alternative meds ivermectin, cbd oil turmeric zinc ashwaganda n dim a natural estrogen blocker solely. Psa came in at .95 down from 1.29, 6 weeks ago and down from 1.95
Gm folks, hope all is well during this Christmas season… I’ve just received my 8th psa test after getting off ADT, 9 months of using alternative meds ivermectin, cbd oil turmeric zinc ashwaganda n dim a natural estrogen blocker solely. Psa came in at .95 down from 1.29, 6 weeks ago and down from 1.95
Nfler
in
Advanced Prostate Cancer
7 months ago
New Radiopharmaceutical Shows Antitumor Activity in Patients with Advanced Prostate Cancer: Tagawa did it again?
That guy is a machine! ARX517 and then this? wow...but what will we do with all the Lutetium?? https://news.weill.cornell.edu/news/2023/11/new-radiopharmaceutical-shows-antitumor-activity-in-patients-with-advanced-prostate It looks like Ac is better than Lu...but it looks like they can even be better
That guy is a machine! ARX517 and then this? wow...but what will we do with all the Lutetium?? https://news.weill.cornell.edu/news/2023/11/new-radiopharmaceutical-shows-antitumor-activity-in-patients-with-advanced-prostate It looks like Ac is better than Lu...but it looks like they can even be better
Maxone73
in
Advanced Prostate Cancer
8 months ago
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