PSMA-Addition Trial can give access to Pluvicto for DeNovo or mHSPC

[MateoBeach]

The range of access to Pluvicto (Lu177-PSMA-617) radionuclide treatment is expanding. Great news. The PSMA-Fore trial recently showed that it iis very beneficial before docetaxel chemotherapy in mCRPC. Now a worldwide trial is exploring it in metastatic hormone sensitive PC, including de novo metastatic. Requirements include no prior chemotherapy (taxane) and generally no ADT or less than 45 days. In my opinion this PSMA-Addition Trial is a great opportunity for those eligible. Thanks to Oliver Sartor and Scott Tagawa et al. Paul/MB

ascopubs.org/doi/10.1200/JC...

clinicaltrials.gov/study/NC...

[MateoBeach]

Have to acknowledge T-A for annnouncing this at the outset in 2021. 👍

[MoonRocket]

This is good news. Thanks for sharing. I'll keep my eye on how this progresses. At the moment I'm on mono-enzalutamide thanks to the EMBARK trial.

[GP24]

Yes, a very interesting trial. But the PSMAddition trial [NCT04720157] has already completed accrual.

[MateoBeach in reply to GP24]

Didn't know that. Dr. Sartor spoke of it this week at the international conference in Melbourne. Perhaps prelim analysis may be not too far off.

[GP24 in reply to MateoBeach]

The new clinicaltrials.gov website makes it difficult to determine this:

Screenshot clinicaltrials.gov

[treedown]

I was excluded from PSMA Addition due to use of Zytiga. The wanted only Lupron. That was year ago.

[MoonRocket in reply to treedown]

You can still get in on the PSMA-Subtraction trial: ADT + Zytiga without Lu177.

[treedown in reply to MoonRocket]

I got lucky on that one, and I'm in. Trial of 1.

[MoonRocket in reply to treedown]

I think I heard of that...Study Numero Uno.

[Brysonal]

very interesting. I applied for PSMAaddition here in the UK when I first went metastatic but it hadn’t started and with mets popping up everywhere I needed to start my ADT so had to travel to Finland to access it whilst treatment naive and hormone sensitive.

No regrets over using ADT combined with Lu-177 x 3 infusions as my first line treatment ( or indeed with follow g up with 3 x Docetaxel ) and I will follow the PSMA addition trial results with interest.

The OVM-200 vaccine trial I did volunteer for is in phase 1b and published its 3 year stability results today so I continue to follow that one too.

PSA negative still this month and still no idea what helped/ didn’t as I tried it all but Lu-177 up front just seems to make sense and as a symptomless fit man with a deadly silent disease it was a very straight forward treatment worth commuting countries to give it a try. It seems much riskier the sicker you get so I have huge hope for OSMAddition to be a positive trial.

Thanks for sharing

[MateoBeach in reply to Brysonal]

So glad to hear your update Brysonal and that you are still doing so well. We are of liike-mind on that. I ask: "What can I do now that may make the difference later, rather than waiting for the disease to advance?" Possibly deflect the trajectory (arrow) of the natural course of progression. Kind regards. Paul

[Maxone73 in reply to Brysonal]

New data for OVM-200?? Now, this is good!!

[Brysonal in reply to Maxone73]

Well news that it’s passed it’s stability tests which they say is an important milestone.

I believe another 24 patients are the plan for this phase of testing which is underway

‘ OVM-200 Drug Product, manufactured to Good Manufacturing Process (GMP), has been certified stable three years post manufacture – a major milestone for OVM’s lead cancer vaccine, OVM-200 Oxford, UK – 31st January 2024 Press Release – OVM-200 major milestone three year stabilty Oxford Vacmedix (OVM), the clinical stage company developing therapeutic cancer vaccines, announced today […]

[Maxone73 in reply to Brysonal]

Can I ask: has it worked for you?

[Brysonal in reply to Maxone73]

No idea but my last scan was clean and PSA undetectable still

I had a lot of beyond SOC treatment so will need the trial to complete to know if it does trigger an immune response.

No regrets taking part in the trial though as no side effects and maybe it works!

[Maxone73 in reply to Brysonal]

Well, no SE is a good starting point! 😀

[Shorehousejam in reply to Brysonal]

Glad you responded, Lu 177 gives no response buy hyper / hypo progression in guys with mutations….cNt wait to they acknowledge that…

[Shellhale]

I would like to know more about this. Dr. Is wanting my husband to start Pluvicto. He is feeling great but urologist seems to think he is failing Xtandi. I was concerned about white blood cell side effects, since he didn't tolerate docetaxel at all and was discontinued. He only has lymph node mets and PSMA shows all mets significantly decreased uptake, no longer lighting up on scan. Just wondering if this is to extreme. PSA has only gone up 1.5 to 2.5. Waiting on new PSA results. DX gleason 9, Oct 2023.