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PSA drops with decreasing Testosterone
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Prostate Cancer Network
4 months ago
Currently in phase 1 but promising: Bispecific Antibody Programs and IL-12 Cytokine, XmAb662
early results are positive on solid tumors, including prostate https://www.pharmaceutical-technology.com/data-insights/xmab-662-xencor-metastatic-castration-resistant-prostate-cancer-mcrpc-likelihood-of-approval-2/ Thanks mhamle01 !!
early results are positive on solid tumors, including prostate https://www.pharmaceutical-technology.com/data-insights/xmab-662-xencor-metastatic-castration-resistant-prostate-cancer-mcrpc-likelihood-of-approval-2/ Thanks mhamle01 !!
Maxone73
in
Advanced Prostate Cancer
7 months ago
At the crossroads (again)
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
rsgdmd
in
Advanced Prostate Cancer
4 months ago
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Rising PSA
Going into 7 years. No prostate. ADT on and off. Recently while on Lupron & NUBEQA PSA continues to rise. Now at 10.1 and Testosterone nondectable. PSMA/PET/CT scan last weeks states no metastases present. We meet with Dr. Aggarwal next week. Last month at our visit he told us at this point “Scans
Going into 7 years. No prostate. ADT on and off. Recently while on Lupron & NUBEQA PSA continues to rise. Now at 10.1 and Testosterone nondectable. PSMA/PET/CT scan last weeks states no metastases present. We meet with Dr. Aggarwal next week. Last month at our visit he told us at this point “Scans
JolleySprings
in
Advanced Prostate Cancer
5 months ago
Rising PSA
I'm Poollover, Just got the results of a blood test and my PSA went up from 0.67 to 0.77. I'm on Orgovyx and Zytiga. I'm 86 years old. How concerned should I be? 8 months ago it was about 12. That was before medication. Also slightly anemic. What are my options? Terry
I'm Poollover, Just got the results of a blood test and my PSA went up from 0.67 to 0.77. I'm on Orgovyx and Zytiga. I'm 86 years old. How concerned should I be? 8 months ago it was about 12. That was before medication. Also slightly anemic. What are my options? Terry
Poollover
in
Advanced Prostate Cancer
4 months ago
Failed Pluvicto
Hello warriors, especially Tall Allen. I'm going on 6 years since Gleason 9 advanced metastatic diagnosis. Had a good run on Zytiga and all the usual other treatments, but just failed last ditch treatment of Pluvicto (after treatment 3). Did genetic testing and no significant mutations. My PSA is
Hello warriors, especially Tall Allen. I'm going on 6 years since Gleason 9 advanced metastatic diagnosis. Had a good run on Zytiga and all the usual other treatments, but just failed last ditch treatment of Pluvicto (after treatment 3). Did genetic testing and no significant mutations. My PSA is
jersy
in
Advanced Prostate Cancer
4 months ago
PSA relapse rate vs testosterone nadir - 3
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
This plot shows the PSA relapse rate after RT and ADT, for Intermediate and High Risk men, comparing different levels of testosterone nadir ( 50 nd/dL). (ref: 2019) The
best
outcomes
are significantly associated with a
lower testosterone nadir ( < 20 ng/dL),
and the relationship
janebob99
in
Advanced Prostate Cancer
4 months ago
Testosterone back to normal
I was diagnosed with PC last April 2023 with PSA of 125. Darilutimide and Relogolix, along with HIIT, plant based diet, and various supplements brought it down to .006. My MO granted a holiday about 6-7 weeks ago, and yesterday, I had my testosterone score. It is back to 312, which is above the number
I was diagnosed with PC last April 2023 with PSA of 125. Darilutimide and Relogolix, along with HIIT, plant based diet, and various supplements brought it down to .006. My MO granted a holiday about 6-7 weeks ago, and yesterday, I had my testosterone score. It is back to 312, which is above the number
Cape1
in
Advanced Prostate Cancer
4 months ago
Triplet and now Radiation?
Hi all - just wanting your thoughts on this. In my profile you would see full details but I will summarize here. 50yr old diagnosed Aug 2nd with PCA with spread to L5 and pubic bone. Original PSA was around 9 and put on Casodex for month, then Lupron every 3 months, plus Darolutamide. Just completed
Hi all - just wanting your thoughts on this. In my profile you would see full details but I will summarize here. 50yr old diagnosed Aug 2nd with PCA with spread to L5 and pubic bone. Original PSA was around 9 and put on Casodex for month, then Lupron every 3 months, plus Darolutamide. Just completed
Yzinger
in
Advanced Prostate Cancer
4 months ago
Prostap injections and bleeding
hello everyone, I’m having a bit of a tough time at the moment, I started prostap injections last year in may without HRT until December, and up until present day having the injection every three months with my daily tibilone tablet. The thing is when I started everything was fine no pain, no bleeding
hello everyone, I’m having a bit of a tough time at the moment, I started prostap injections last year in may without HRT until December, and up until present day having the injection every three months with my daily tibilone tablet. The thing is when I started everything was fine no pain, no bleeding
Leenie0811
in
Endometriosis UK
11 months ago
No more enzalutamide: docetaxel next up
So enzalutamide has stopped doing its thing. PSA up to 3.9 but it’s worked for 3.5 years. Also got a new lesion in my thoracic spine so in addition to docetaxel, a single dose of radiotherapy. Hope that will all be underway within a couple of weeks. Some fear for a while about the meds not working and
So enzalutamide has stopped doing its thing. PSA up to 3.9 but it’s worked for 3.5 years. Also got a new lesion in my thoracic spine so in addition to docetaxel, a single dose of radiotherapy. Hope that will all be underway within a couple of weeks. Some fear for a while about the meds not working and
FortyWinks
in
Advanced Prostate Cancer
4 months ago
How Genomic Biomarkers are Shaping Treatment Decisions
Big Data and AI are powerful... https://www.urotoday.com/video-lectures/prostate-cancer-genomic-classifier/video/mediaitem/3634-deciphering-prostate-cancer-how-genomic-biomarkers-are-shaping-treatment-decisions-paul-nguyen.html
Big Data and AI are powerful... https://www.urotoday.com/video-lectures/prostate-cancer-genomic-classifier/video/mediaitem/3634-deciphering-prostate-cancer-how-genomic-biomarkers-are-shaping-treatment-decisions-paul-nguyen.html
Maxone73
in
Advanced Prostate Cancer
7 months ago
Dual Action Hormone Therapy Targeting Two Parts of Androgen Receptor for mCRPC
Phase I/II trial of masofaniten combined with enzalutamide, a novel hormonal therapy for mCRPC. Masofaniten, a first-in-class N-terminal ligand antagonist for the androgen receptor, shows promise in overcoming resistance to current hormonal therapies. Hopefully a new weapon for us!
Phase I/II trial of masofaniten combined with enzalutamide, a novel hormonal therapy for mCRPC. Masofaniten, a first-in-class N-terminal ligand antagonist for the androgen receptor, shows promise in overcoming resistance to current hormonal therapies. Hopefully a new weapon for us!
Maxone73
in
Advanced Prostate Cancer
7 months ago
Warren Farr
Hi, my name is warren I was diagnosed in late November 2023 with Prostrate Cancer from a MRI I then had a PSMA CT Scan and the next day Robotic removal of my prostrate RRP. The Biopsy showed staging pT3b 30% ductal after a Gleason score of 5+4=9 My PSA after removal was 0.22 then 4 weeks later 0.38
Hi, my name is warren I was diagnosed in late November 2023 with Prostrate Cancer from a MRI I then had a PSMA CT Scan and the next day Robotic removal of my prostrate RRP. The Biopsy showed staging pT3b 30% ductal after a Gleason score of 5+4=9 My PSA after removal was 0.22 then 4 weeks later 0.38
Snoopy8125
in
Advanced Prostate Cancer
4 months ago
PSA Gone Up
I had RP in January of 2023, started ADT in May of 2023 and went through 38 session of SRT between July and August. In am currently on my second six month dose of Eligard and it should be done in May of this year. In November 2023, I had my first PSA test since SRT and it was .008 ng/mL. I just got
I had RP in January of 2023, started ADT in May of 2023 and went through 38 session of SRT between July and August. In am currently on my second six month dose of Eligard and it should be done in May of this year. In November 2023, I had my first PSA test since SRT and it was .008 ng/mL. I just got
toyman79912
in
Advanced Prostate Cancer
5 months ago
Pinostilbene inhibits the Enz-resistant CRPC cell line by inhibiting AR variant 7
i take pterostilbene daily which pinostilbene is a metabolite of pterostilbene. in any event if you are failing on enzalutamide or any PCa warrior you probably should take pterostilbene. Below is a 2023 in-depth article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550987/ Pinostilbene inhibits
i take pterostilbene daily which pinostilbene is a metabolite of pterostilbene. in any event if you are failing on enzalutamide or any PCa warrior you probably should take pterostilbene. Below is a 2023 in-depth article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550987/ Pinostilbene inhibits
KocoPr
in
Fight Prostate Cancer
7 months ago
My Oligometastatic PCa Journey Continues...coming up on year 9!
It's been a while since I've posted. But wanted to offer a note of
encouragement
for those here that have
oligometastatic prostate cancer
. I was diagnosed in 2015 (227 PSA, Gleason 8, 1 MET in the spine) and still going strong. After years of
hormone therapy
, 6 rounds of
chemo
It's been a while since I've posted. But wanted to offer a note of
encouragement
for those here that have
oligometastatic prostate cancer
. I was diagnosed in 2015 (227 PSA, Gleason 8, 1 MET in the spine) and still going strong. After years of
hormone therapy
, 6 rounds of
chemo
JamesAtlanta
in
Advanced Prostate Cancer
5 months ago
Studies help explain why some prostate cancers become resistant to hormone therapy
https://www.sciencedaily.com/releases/2023/12/231204135037.htm
https://www.sciencedaily.com/releases/2023/12/231204135037.htm
zeitgeistxx
in
Advanced Prostate Cancer
7 months ago
Avodart and Flomax
Hello brothers. Is it safe to use Avodart and Flomax with advanced prostate cáncer? I am tired of getting up to pee 7 or 8 times a night.
Hello brothers. Is it safe to use Avodart and Flomax with advanced prostate cáncer? I am tired of getting up to pee 7 or 8 times a night.
CountryJoe
in
Advanced Prostate Cancer
7 months ago
After 2 Nuclear Ligand treatments should I still have severe bone pain in my lower back?
My SO was diagnosed last year with stage 4 Prostate cancer. Although his PSA never went extremely high (8.0) his Gleason scores were two 8's and a 9. The cancer when diagnosed consumed his complete prostate and was found in the vertebras of his neck, shoulder and shoulder socket plus his pelvis and
My SO was diagnosed last year with stage 4 Prostate cancer. Although his PSA never went extremely high (8.0) his Gleason scores were two 8's and a 9. The cancer when diagnosed consumed his complete prostate and was found in the vertebras of his neck, shoulder and shoulder socket plus his pelvis and
chuigk
in
Advanced Prostate Cancer
4 months ago
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