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Carnosine as potential initial PCa treatment
Researchers have discovered that a naturally-occurring molecule could potentially be an effective first line of treatment against prostate cancer. Nottingham Trent University (NTU) scientists investigated the anti-cancer properties of carnosine, which can be produced in the body and is also found
Researchers have discovered that a naturally-occurring molecule could potentially be an effective first line of treatment against prostate cancer. Nottingham Trent University (NTU) scientists investigated the anti-cancer properties of carnosine, which can be produced in the body and is also found
Derf4223
in
Advanced Prostate Cancer
6 months ago
PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
4 months ago
PSA Rising After PBRT
Underwent prostate bed radiation in 2022 with good results — about a year of PSA at .02 to .05 — past six months, .09 and now at .17 Will get a PSMA-PET, but am curious what’s next ??
Underwent prostate bed radiation in 2022 with good results — about a year of PSA at .02 to .05 — past six months, .09 and now at .17 Will get a PSMA-PET, but am curious what’s next ??
FLRichardson
in
Advanced Prostate Cancer
3 months ago
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Clinical Trial PT 112 ?
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
Enilorac63
in
Advanced Prostate Cancer
4 months ago
Good News! Pluvicto Update
Hey Guys, I just had my third round of Pluvicto this last Tuesday. I had bloodwork done last week. The news seems promising: On 28 January (after docetaxel, but before Pluvicto), my PSA was 36.2. After 2 rounds of Pluvicto on 8 April, my PSA had dropped to 14.5! So, I am remaining positive! I have
Hey Guys, I just had my third round of Pluvicto this last Tuesday. I had bloodwork done last week. The news seems promising: On 28 January (after docetaxel, but before Pluvicto), my PSA was 36.2. After 2 rounds of Pluvicto on 8 April, my PSA had dropped to 14.5! So, I am remaining positive! I have
MJCA
in
Advanced Prostate Cancer
3 months ago
How do you know if radiation treatment worked?
I had 25 sessions of radiation to prostate and pelvic area as a precaution and 6 (2 months prior and 4 after radiation)months of Lupron. For 9 months post radiation PSA has been not been detectable and it has now risen to 0.04. T is in the normal range. All other blood works were normal. Meet with
I had 25 sessions of radiation to prostate and pelvic area as a precaution and 6 (2 months prior and 4 after radiation)months of Lupron. For 9 months post radiation PSA has been not been detectable and it has now risen to 0.04. T is in the normal range. All other blood works were normal. Meet with
Mgtd
in
Advanced Prostate Cancer
3 months ago
Is it PSA recurrence or not...
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
traveller64
in
Advanced Prostate Cancer
4 months ago
Mortality Probability after first PSA rise vs non-castrate testosterone levels (low vs Normal)
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
janebob99
in
Advanced Prostate Cancer
4 months ago
First PSA after RARP
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
Pca2024
in
Advanced Prostate Cancer
4 months ago
PSA reduction after Estrogen Patch Therapy
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
janebob99
in
Advanced Prostate Cancer
4 months ago
Need advice on clinical trial RO7656594
I have updated our profile, but in a nutshell we've gone through abiraterone, Xtandi, docetaxel, Pluvicto , cabazitaxel and carboplatin. My husband's most recent PSA on 4/12 was 79.52. His MO has put a hold on chemo our last 3 appointments due to pancytopenia. He's received 2 blood transfusions on his
I have updated our profile, but in a nutshell we've gone through abiraterone, Xtandi, docetaxel, Pluvicto , cabazitaxel and carboplatin. My husband's most recent PSA on 4/12 was 79.52. His MO has put a hold on chemo our last 3 appointments due to pancytopenia. He's received 2 blood transfusions on his
Yadifan
in
Advanced Prostate Cancer
3 months ago
Should I Add Docetaxel to Lupron and Zytiga?
I have been on Lupron and Abiraterone for most of my almost 12 years of treatment. Triplet therapy was not SOC when I was first dx'd. I am just wondering why, Docetaxel isn't routinely added to those of us who started on doublet therapy before we become resistant to the doublet therapy. My guess is that
I have been on Lupron and Abiraterone for most of my almost 12 years of treatment. Triplet therapy was not SOC when I was first dx'd. I am just wondering why, Docetaxel isn't routinely added to those of us who started on doublet therapy before we become resistant to the doublet therapy. My guess is that
jfoesq
in
Advanced Prostate Cancer
3 months ago
PSA drop with decreasing Testosterone after Estrogen Patch Therapy
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Advanced Prostate Cancer
4 months ago
PSA spiked from .6 to 8.0 in 3 months
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
crony
in
Advanced Prostate Cancer
4 months ago
My prostate history
In 2020 at age 66 years I was diagnosed with prostate cancer. DRE was negative. TRUS Prostate biopsy positive: Gleason score 7 (3+4) left lateral base, Gleason score 6 (3+3) left lateral apex. Treatment plan: Active Surveillance. In February 2024, Rise in PSA 12.8, compared to 5.8 six months earlier
In 2020 at age 66 years I was diagnosed with prostate cancer. DRE was negative. TRUS Prostate biopsy positive: Gleason score 7 (3+4) left lateral base, Gleason score 6 (3+3) left lateral apex. Treatment plan: Active Surveillance. In February 2024, Rise in PSA 12.8, compared to 5.8 six months earlier
BobDad
in
Prostate Cancer Network
3 months ago
Nagalase count
My nagalase count is declining. 1.55 -1.37 - 1.12 today. The Clioquinol +zinc +ivermicetin is still working on the way to zero. PSA is steady at 32 Nagalase is an enzyme that cancer cells produce to protect themselves from the immune system.
My nagalase count is declining. 1.55 -1.37 - 1.12 today. The Clioquinol +zinc +ivermicetin is still working on the way to zero. PSA is steady at 32 Nagalase is an enzyme that cancer cells produce to protect themselves from the immune system.
agnut
in
Fight Prostate Cancer
3 months ago
Pain Management
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Nyon
in
Advanced Prostate Cancer
4 months ago
Side effects from Xtandi monotherapy?
after failing multiple times on regular ADT plus SBRT and finally failing LU– 177 and Provenge, my PSA went on the rise again. I’ve been on mono Xtando for six weeks and not feeling well despite trying to exercise heavily. Going in for bloodwork tomorrow. What kind of labs should I ask for? Anyone
after failing multiple times on regular ADT plus SBRT and finally failing LU– 177 and Provenge, my PSA went on the rise again. I’ve been on mono Xtando for six weeks and not feeling well despite trying to exercise heavily. Going in for bloodwork tomorrow. What kind of labs should I ask for? Anyone
SViking
in
Advanced Prostate Cancer
3 months ago
What is Your Opinion on Docetaxel Added to Doublet Therapy for Early Oligorecurrent Metaststic M1a Prostate Cancer?
Hello, I have touched on this subject before, but it is something that is nagging at me and giving me some sleepless nights. My husband’s bio is updated for reference. At one year post prostatectomy with Stage 3b, he rose from 0.06 to 0.273 in three mos. At psa of 0.16 , a PSMA scan showed three sub
Hello, I have touched on this subject before, but it is something that is nagging at me and giving me some sleepless nights. My husband’s bio is updated for reference. At one year post prostatectomy with Stage 3b, he rose from 0.06 to 0.273 in three mos. At psa of 0.16 , a PSMA scan showed three sub
103532
in
Advanced Prostate Cancer
3 months ago
Opinions on my 2nd MRI results
Hello, I just received the results from 2nd MRI (results below and photos in reply), previous one was from Jan/2023 (results in bio). Having been on these forums for almost two years now, and in AS at UCLA, I highly value the opinion of those here that have similar experiences to my situation. Questions
Hello, I just received the results from 2nd MRI (results below and photos in reply), previous one was from Jan/2023 (results in bio). Having been on these forums for almost two years now, and in AS at UCLA, I highly value the opinion of those here that have similar experiences to my situation. Questions
Maximode
in
Prostate Cancer Network
3 months ago
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