Hi All,
I’m new on here and can’t believe just how brilliant this forum is so thanks for having me!!! (Apologies for the lengthy post).
I am a 29-year-old male that has had to return recently from Australia where I’ve been working for 8 years because of my undiagnosed illness, and am living with my parents (until I’m well again).
Hypothyroidism runs strongly in my family (aunty, mother, grandmother, male cousin and sister all have it) and I understand that my symptoms fit the bill but this has been disregarded because of my blood results so now I am going down the Vitamin B12 deficiency route. The symptoms that I’ve had for at least 6 months (probably getting worse over years now I think about it) are Extreme exhaustion / fatigue, Head fog / poor concentration, Dizziness / vertigo / balance problems, slow movements, thoughts and speech, poor focussing / double vision, memory loss / confusion, mental sluggishness, muscle cramps / weakness / joint aches, cold hands / feet, shortness of breath, high blood pressure 140/90, chronic cough that comes and goes aches and pains in joints, rash on cheeks that itches, itchy flakey scalp, hoarse voice, lack of coordination, joint stiffness, hot / cold intolerance and alcohol intolerance.
I have had a panel of blood tests which are below (range in brackets) and am currently on no medication. GP said I’m not Hypothyroid - Do you believe that I could be B12 deficient with these results? Or if it’s worth going to an Endocrinologist. If not, have you any idea where to point me next as my GP’s have run out of options. Thanks so much for any assistance at all. Have a neurologist appointment booked in for tomorrow so hoping he can shed some light! Is there anything I should ask him?
In addition to my blood tests I’ve also had a brain MRI, knee MRI and Chest X-Ray that has come back as normal.
Just trying to keep positive at the moment and know that I will eventually get diagnosed. Thanks so much for any advice / assistance provided.
Blood Tests
TSH = 2.83 mU/L (0.30 – 4.40) – Previous test in 2015 was 3.02
FT4 = 15.8 pmol/L (9.0 – 19.1)
FT3 = 4.2 pmol/L (2.6 – 5.7)
Thyroglobulin Ab = 2.3 IU/mL (<4.1)
Thyroid Peroxidase Ab = 2 IU/mL (<6) – Was .8 in Nov 2018
Folate S.Fol (Abbott) = 19.7 nmol/L (>7) and 12ug/L (>3) when taken last week.
Vit B12 = 180 pmol/L (135-650) and when measured last week 242 ng/L (130-900)
Vit D = 96 nmol/L (>50)
Active B12 = 66 pmol/L (>35)
Ferritin = 164 ug/L (30-300)
Iron = 18.7 umol/L (5-30)
Transferrin = 2.4 g/L (2-3.2)
TIBC (calc) = 54 umol/L (46-70)
Saturation = 35% (10-45)
DHEAS = 19.2 umol/L (3-16)***
PSA = 0.46 ug/L (.2-2)
Immunoglobulins
Immunoglobulin G = 10.74 g/L (6.2-14.4)
Immunoglobulin A = 4.46 g/L (.6-3.96)***
Immunoglobulin M = 1.6 g/L (0.48-3.04)
Immunoglobulin E = 101 IU/mL (<100)***
Allergy Serology
Cat epithelium = <0.01 kU/L Class 0 = Negative
Dog dander = <0.01 kU/L Class 0 = Negative
Grass Pollen = 0.34 kU/L Class 0 = Negative
Dustmite = 0.02 kU/L Class 0 = Negative
Alternaria alternata = 0.01 kU/L Class 0 = Negative
Haematology
Haemoglobin = 163 g/L (130-180)
RCC = 5.6 x10>12/L (4.5-6.5)
Haematocrit = .48 (0.39-0.54)
MCV = 86 fL (80-100)
MCH = 29.2 pg (27-32)
MCHC = 338 g/L (310-360)
RDW = 12.9 (10-15)
WCC = 5.8 x10>9/L (4-11)
Neutrophils = 3.33 x10>9/L (2-7.5)
Lymphocytes = 1.91 x10>9/L (1-4)
Monocytes = 0.43 x10>9/L (0 – 1)
Eosinophils = 0.06 x10>9/L (0.0-0.5)
Basophils = 0.04 x10>9/L (0.0-0.3)
NRBC = <1 x100WBC (<1)
Platelets = 249 x10>9/L (150-450)
ESR = 3 mm/h (1-20)
Biochemistry
Sodium = 140 mmol/L (135-145)
Potassium = 4.2 mmol/L (3.5-5.5)
Chloride = 103 mmol/L (95-110)
Bicarbonate = 28 mmol/L (20-32)
Urea = 6 mmol/L (3-7.5)
Creatinine = 85 mmol/L (60-110)
eGFR = >90 mL/min/1.73m2 (>59)
Bili Total = 12 umol/L (4-20)
ALP = 53 U/L (35-110)
GGT = 25 U/L (5-50)
LD = 149 U/L (120-250)
AST = 26 U/L (10-40)
ALT = 50 U/L (5-40)***
Phosphate = .96 mmol/L (.8-1.5)
Magnesium = 0.79 mmol/L (0.65-1)
Corr Calcium = 2.32 mmol/L (2.15-2.55)
Calcium = 2.3 mmol/L (2.15-2.55)
Serum Protein Electrophoresis (EPG)
Total Protein = 74 g/L (68-85)
Albumin = 48 g/L (39-50)
Globulin = 28 g/L (23-39)
Alpha 1 Globulin = 1.7 g/L (1-3)
Alpha 2 Globulin = 5.8 g/L (4-10)
Beta Globulin = 8.6 g/L (5-11)
Gamma Globulin = 9.8 g/L (7-16)
CK = 94 U/L (45-250)
CRP = 0.7 mg/L (0-5)
Cortisol AM = 464 nmol/L (138-650)
Antibodies to Extractable Nuclear Antigen (ENA)
SS-A 60 = Negative
SS-B = Negative
Ro-52 = Negative
Scl-70 = Negative
Jo-1 = Negative
Cenp-B = Negative
Sm = Negative
RNP = Negative
Ribo-P = Negative
Rheumatold Factor (Quantitative)
Rheumatold Factor (RF) = <6 IU/mL (<16)
Epstein-Barr Virus Serology
EBV VCA IgG = Detected
EBV NA IgG = Detected
EBV VCA IgM = Not Detected
Evidence of past, not current, EBV infection
Cytomegalovirus Serology
CMV IgG (CMIA) = Detected
CMV IgM (CMIA) = Not Detected
Suggestive of past, not current, CMV infection
Glucose
F Gluc Plasma = 5.1 mmol/L (3.6-6)
Lipids and HDL
Cholesterol = 5 mmol/L (3.9-5.5)
Triglycerides = 0.7 mmol/L (0.5-1.7)
HDL Chol. = 1.1 mmol/L (0.8-1.5)
LDL Chol. = 3.6 mmol/L (1.7 – 3.5)***
Androgens
Testosterone = 21.9 nmol/L (11.5-32)
SHBG = 35 nmol/L (15-50)
Calculated Free Testosterone = 468 pmol/L (260-740)
Mercury-blood = 53 nmol/L (<60)
Plasma Metanephrines
P-Normetanephrine = 340 pmol/L (<590)
P-Metanephrine = 330 pmol/L (<447)
P-3 Methoxy tyramine = <50 (<181)
Cyclic Citrullinated Peptide Antibodies = <5 U/mL (<5)
Coeliac Serology
Deamidated Gliadin IgA 2 U/mL (<15)
Deamidated Gliadin IgG <1 U/mL (<15)
Tissue Transglutaminase IgA <1 U/mL (<15)
Tissue Transglutaminase IgG <1 U/mL (<15)
Anti-DNA Antibodies (RIA) <5 IU/mL (0-6)
Lyme IgG = Negative
Lyme IgM = Negative
HIV ½ Antigen and Antibody = Negative
Hepatitus C Ab Abbott = Not Detected
Hepatitus C = Not Detected
Chlamydia trachomatis PCR = Not Detected
Neisseria gonorrhoeae = Not Detected
Hepatitis B Surface Ag = Not Detected
Hepatitus B Surface Ab = Not Detected
No evidence of hepatitis B infection