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Type 3 deiodinase activation mediated by the Shh/Gli1 axis promotes sepsis-induced metabolic dysregulation in skeletal muscles
Non-thyroidal illness syndrome has always seemed to mystify medicine. Dropping T3 precisely when it might be needed!
Dys-regulation of the DIO3 deiodinase enzyme might explain what is happening. And open the doors to a beneficial treatment. Simply increasing thyroid hormone medicines has not been successful