Posts - Fight Prostate Cancer | HealthUnlocked

Fight Prostate Cancer

3,035 members•1,516 posts

All posts for April 2025

Repurposing advances

AI-driven drug repurposing platform offers new hope for cancer patients by reviving abandoned drugs in just 12 weeks. Using a biobank of over 150,000...

AI-driven drug repurposing platform offers new hope for cancer patients by reviv...

•2 days ago

Medical Oncologist needed

My insurance lapsed in 2024 and now I'm in need of an MO. Most of you probably know that I am not about to do the SOC thing. So most MOs are out. I only...

My insurance lapsed in 2024 and now I'm in need of an MO. Most of you probably...

•2 days ago

Anabolism: which is beter? Ostarine or NPP?

Comparison of Ostarine (5 mg/day) vs. NPP (250 mg/week) in High-T pBAT Anabolic Effects ParameterOstarine (5 mg/day)NPP (250 mg/week) AR ActivationSelective...

Comparison of Ostarine (5 mg/day) vs. NPP (250 mg/week) in High-T pBAT Anabolic...

•2 days ago

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MK-2400 Phase 1 will start recruiting soon

The investigational TROP2-directed ADC, MK-2400, has shown significant promise with a notable 52.4% objective response rate in challenging non-small cell lung...

The investigational TROP2-directed ADC, MK-2400, has shown significant promise w...

•3 days ago

SARMS, Anabolic, androgen etc..

Hi all. Reminder im a PCa brother, been through the chemo and radiation and now living in 3mth intervals 😀 waiting on PSA results. Although I'm extremely...

Hi all. Reminder im a PCa brother, been through the chemo and radiation and now ...

•4 days ago

Newsletter 15 is out

As usual keep an eye on the spam folder Have a great Sunday! Max

As usual keep an eye on the spam folder Have a great Sunday! Max

•5 days ago

oral testosterone undecanoate

OTU is great for some purposes. But max that can be taken at one time is limited by lymphatic channels. I think it's around 400-800 mg. Older formulas need to...

OTU is great for some purposes. But max that can be taken at one time is limite...

•5 days ago

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BST (bipolar SARM therapy)

I wish the doctors started thinking of us as humans. Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program...

I wish the doctors started thinking of us as humans. Selective androgen recepto...

•5 days ago

intermittent fasting works better than diet it seems

when I asked my MO last year, he told me that even if I am under darolutamide I could do a 14:10 fasting, especially since I have been using it for a while and...

when I asked my MO last year, he told me that even if I am under darolutamide I ...

•6 days ago

Phase 2 BAT trial recruiting soon: BAT + ZEN-3694, Denmeade strikes again!

The COSMYC Trial is a Phase 2 clinical trial investigating a novel sequential treatment strategy for men with metastatic castration-resistant prostate cancer...

The COSMYC Trial is a Phase 2 clinical trial investigating a novel sequential tr...

•7 days ago

Phase 2 trial: 225Ac + Olaparib combo

Note: in this setting, for this trial, no HRR mutation is required (like BRCA, ATM, ...). The treatment should basically (from my understanding) bomb the...

Note: in this setting, for this trial, no HRR mutation is required (like BRCA, A...

•7 days ago

Vemurafenib - PTEN loss

It seems that V has a good effect on Ocs who has the PTEN Loss mutation, inhibiting MAPK, thru CDK6. Anybody tried that drug off label?

It seems that V has a good effect on Ocs who has the PTEN Loss mutation, inhibit...

•8 days ago

Phase 1: SVV-001 for neuroendocrine solid tumors

Why not "non neuroendocrine"?? Time will tell! But here is another application of an oncolytic virus... The Sylvester Comprehensive Cancer Center has launched...

Why not "non neuroendocrine"?? Time will tell! But here is another application o...

•8 days ago

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Preclinical: optimized delivery looks very promising!

Delivery is one of the most critical factors. Whether we're dealing with a drug or a natural compound from a supplement, having the right 'ingredient' means...

Delivery is one of the most critical factors. Whether we're dealing with a drug ...

•8 days ago

Practically guaranteed HSPC->CRPC if you do ADT

There are outliers. Someday, it'd probably be helpful to find out why. Genetics, chemo, RT, luck? But for most of us, if we pursue ADT, we WILL develop CRPC....

There are outliers. Someday, it'd probably be helpful to find out why. Genetics,...

•8 days ago

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Thoughts about darolutamide monotherapy for BAT

I would like to decrease my drug burden. Darolutamide has been demonstrated to be superior to standard ADT monotherapy. For cycles lasting a week or more I...

I would like to decrease my drug burden. Darolutamide has been demonstrated to b...

•8 days ago

Radiosensitizer Tests

We can test radiosensitivy and that'll give us three items of info. 1. Does it appear that radiotherapy will work well (provided we are relying on ADT or...

We can test radiosensitivy and that'll give us three items of info. 1. Does it...

•9 days ago

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Update, Phase 2 trial results: FC705 Outperforms Pluvicto

There we go, this is a great update! Pluvicto’s been the go-to standard, but new research like FC705 is totally blowing past it... FC705, a new radioligand...

There we go, this is a great update! Pluvicto’s been the go-to standard, but new...

•9 days ago

Need data

I have an HSPC->CRPC prediction tool. Some of the components have been validated in clinical trials (STAMPEDE, PROPHECY, etc) and the rest have been "verified"...

I have an HSPC->CRPC prediction tool. Some of the components have been validated...

•9 days ago

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HSPC->CRPC prediction

If we have access to RNA proteomic testing there are 6 genes that can be used to predict the transition 18-24 months in advance with a specificity of 91% and a...

If we have access to RNA proteomic testing there are 6 genes that can be used to...

•10 days ago

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Another HSPC->CRPC predictor

This one is simple to measure. Standard blood test. CgA is a simple blood test also but is $175 vs. DHT is $45.

This one is simple to measure. Standard blood test. CgA is a simple blood test a...

•10 days ago

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Another CRPC predictor - CgA

HSPC->CRPC predictors.

HSPC->CRPC predictors.

•10 days ago

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Curcumin as an immunomodulator

I looked at this specifically for BAT. SPA might synergize with immunomodulators. As it often happens, I can't get the drugs that are powerful...

I looked at this specifically for BAT. SPA might synergize with immunomodulators...

•10 days ago

BAT (bipolar androgen therapy)

Has anyone tried this and had any success with it?

Has anyone tried this and had any success with it?

•11 days ago

Have you received the newsletter?

I ask because I have noticed a strangely low number of email openings.I wonder if some email providers enabled even stricter spam filters!

I ask because I have noticed a strangely low number of email openings.I wonder i...

•11 days ago

A couple of HSPC->CRPC defintions. One general, one BAT

The formatting doesn't come through. BAT in HSPC (HSPC Classification) Key Definitions 1.HSPC (Hormone-Sensitive Prostate Cancer): •Cancer responds to...

The formatting doesn't come through. BAT in HSPC (HSPC Classification) Key...

•11 days ago

Preclinical but very promising (not joking), SABER molecule increases vaccines efficacy

Preclinical but seriously powerful...well, at least on mice, but wow... we are talking about up to 120x stronger CD8⁺ T cell responses.... A new preclinical...

Preclinical but seriously powerful...well, at least on mice, but wow... we are t...

•11 days ago

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PGV001 vaccine for solid tumors phase 1 results

It was not tested on prostate cancer but they are planning to do it, plus it's anyway a promising result! A phase 1 trial of the personalized cancer vaccine...

It was not tested on prostate cancer but they are planning to do it, plus it's a...

•11 days ago

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Newsletter 14 is out

Have a great Sunday! Max

Have a great Sunday! Max

•12 days ago

Buying through Indiamart

I always struggled to buy drugs from India. But now with chatbots. Ask them to rate the vendor. I found one that seemed reliable, has good prices, and was...

I always struggled to buy drugs from India. But now with chatbots. Ask them to r...

•12 days ago

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