Phase 2 BAT trial recruiting soon: BAT + ZEN-3694, Denmeade strikes again!

[Maxone73]

The COSMYC Trial is a Phase 2 clinical trial investigating a novel sequential treatment strategy for men with metastatic castration-resistant prostate cancer (mCRPC).

This open-label study will evaluate if combining ZEN-3694, a BET inhibitor, with high-dose testosterone (BAT) can shrink tumors and delay progression in patients resistant to standard therapies. Upon progression on BAT and ZEN-3694 (BATZEN), patients will transition to a combination of a higher dose of ZEN-3694 and enzalutamide (ZENZA).

This approach targets MYC-driven pathways and aims to overcome resistance to androgen receptor inhibitors

The primary goals are to assess if BATZEN improves progression-free survival (PFS) and if ZENZA enhances PSA-progression-free survival.

The trial is expected to begin in June 2025 and conclude by June 2031, under the leadership of Dr Samuel Denmeade at Johns Hopkins.

prostatewarriors.com/2025/0...

[PCaWarrior]

Curcumin and EGCG are weak MYC inhibitors. If COSMYC succeeds, perhaps curcumin/EGCG might synergize with BAT. They are orders of magnitude weaker than ZEN-3694 and BET inhibition is indirect. But you can get them. And they don't have many side effects.

[Teufelshunde in reply to PCaWarrior]

And you dont have to wait 6 years!!

[petabyte]

BAT makes for some great trial names: wombat, batman, combat, acrobat... 😎

[PCaWarrior in reply to petabyte]

Perplexity told me my next steps for cyclical pBAT are to run lab studies and a clinical. It suggested the name BATGUARD.

[petabyte in reply to PCaWarrior]

🙃 I'd like to see this: Bipolar Androgen Therapy Strategies for Hormone-Independent Tumors

[Maxone73 in reply to petabyte]

😂😂

[PCaWarrior in reply to petabyte]

HSPC?

BATMAN, and pBAT

[Maxone73 in reply to PCaWarrior]

read just the initials....

[PCaWarrior in reply to Maxone73]

Lol! I'm slow...

[PCaWarrior]

25 BAT trials now. Complete or recruiting.

[Professorgary in reply to PCaWarrior]

Denmeade just switched me from prednisone to dexamethasone which is working for now but some form of BAT will be my next treatment.

[PCaWarrior in reply to Professorgary]

Do you have any mutations? You probably know more about the corticosteroid switch than most any of us since you're going through it.

[Professorgary in reply to PCaWarrior]

No mutations. There are several prognostic factors to determine the success probability of the switch. Psa below 50, alp below 160, short time until progression on abi and if you have an ACR1c3 over expression. My psa dropped 28% in the first 3and a half weeks. Only time will tell.