Update, Phase 2 trial results: FC705 Outperforms Pluvicto

[Maxone73]

There we go, this is a great update! Pluvicto’s been the go-to standard, but new research like FC705 is totally blowing past it...

FC705, a new radioligand therapy for metastatic castration-resistant prostate cancer (mCRPC), outperformed Pluvicto in phase 2 trials, achieving a 60.0% tumor response rate compared to Pluvicto’s 29.8% (and it works on both lymphnode and bone metastases, Pluvicto works only on lymphnode mets).

FC705 also showed a higher PSA 50 response rate of 73.3% versus Pluvicto’s 46.0%, indicating better disease control.

FC705 maintained a comparable safety profile with a 10.0% serious adverse reaction rate, slightly higher than Pluvicto’s 9.3%. A phase 3 IND application has been submitte in South Korea and a phase 2a trial in the U.S. is ongoing. The drug’s orphan designation may expedite conditional approval.

prostatewarriors.com/2025/0...

[Fonske]

almost to good to be true BUT I want to believe 😀

[Maxone73 in reply to Fonske]

Me too! Phase 2 was almost 100 patients if I am not wrong, I want to hope that they were not cherry picked. But I know that their stocks value soared by 20% 2 days ago, and it seems that some major players started talking to them for future licensing 🤷‍♂️

[Rolphs]

It seems like there are several possible radiopharmaceutical competitors to Pluvicto. Do you know if Cu-SAR-bisPSMA works in the same way as FC705?

As always Thanks for the update!

[Maxone73 in reply to Rolphs]

Of course they use a different radiologand, Lu vs Cu, SAR-bisPSMA is still a psma ligand while FC705 is....a psma ligand as well! 😀 seriously, they have different ligand mechanism and both look way better than PSMA-617 used by pluvicto. I would keep an eye on both new products. Cu67 gave some impressive results, like complete response.

[Rolphs in reply to Maxone73]

I’m glad we have someone who can translate the science for a mostly befuddled liberal arts major.

Thanks!

[Oldie68]

Interesting. Reference, please.

[Maxone73 in reply to Oldie68]

Follow the link, the reference is at the bottom of the article

[Oldie68 in reply to Maxone73]

Thanks!

[Maxone73 in reply to Oldie68]

Noooo prob!

[petabyte]

Impressive results in the current climate 😛

FutureChem's stock price jumped more than 20% in the after-market (3:40 p.m.-8 p.m.) on the 8th.

[Maxone73 in reply to petabyte]

Eh, not bad at all

[Peppertree602]

love you Max!

What effort you put in

Thank you

[Maxone73 in reply to Peppertree602]

😍 I read from the other forum that your PSA went down where it belongs. Fight on!