Posts - Fight Prostate Cancer | HealthUnlocked

Fight Prostate Cancer

2,800 members • 1,030 posts

All posts for July 2023

Colchicine and Inflammation Reconsidered

Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion...

Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” wh...

•9 months ago

Alpha PSMA & New Targets in Prostate Cancer | ProsTIC/PCF Global Webinar Link

Please find below the link to the recent, very comprehensive and interesting podcast. It's provided for the members of HU who have contacted me and indicated...

Please find below the link to the recent, very comprehensive and interesting po...

•9 months ago

Low-dose Aspirin.

I imagine that the new aspirin study [JAMA (1)] will get a lot of media play, but I will post anyway. A previous study concluded that the only people who...

I imagine that the new aspirin study [JAMA (1)] will get a lot of media play, bu...

•9 months ago

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Does this mean we sould not use ubiquinol?

I would prefer not to drop ubiquinol, but this makes me think maybe I should? “Castration-resistant prostate cancer (CRPC) poses a major clinical challenge...

I would prefer not to drop ubiquinol, but this makes me think maybe I should? “...

•9 months ago

Finished First BAT Cycle

First BAT Cycle with numbers Even though I had just finished 1 year on Darolutamide, Orgovyx, and Non SOC 10mg Osterine and 10mg Cardarine every day with...

First BAT Cycle with numbers Even though I had just finished 1 year on Darolu...

•9 months ago

HMB Supplement for Muscle and Brain Health?

I was alerted to the potential benefit of this supplement by a family member with Parkinsons. A benefit for sarcopenia is also mentioned. I haven't tried it...

I was alerted to the potential benefit of this supplement by a family member wit...

•9 months ago

CCNA2

New paper below [1]. I was intrigued by the title: "Comprehensive analysis of the progression mechanisms of CRPC and its inhibitor discovery based on...

New paper below [1]. I was intrigued by the title: "Comprehensive analysis...

•9 months ago

Rutin / Senolytics

New paper below [1]. In 1995, Edward Giovannucci was responsible for triggering the PCa lycopene craze. "Of 46 vegetables and fruits or related...

New paper below [1]. In 1995, Edward Giovannucci was responsible for triggeri...

•9 months ago

Waiting for PSA Rise Post-Surgery Before Obtaining PSMA-PET– waiting too long can put some patients at risk, MedPage Today, July 6, 2023.

Anthony D'Amico, MD, on Waiting for PSA Rise Post-Surgery Before Obtaining PSMA-PET – Study suggests that waiting too long before obtaining PSMA-PET can...

Anthony D'Amico, MD, on Waiting for PSA Rise Post-Surgery Before Obtaining PSMA-...

•9 months ago

Dual ARi in mCRPCa - Antonarakis = 'Combo of 2 AR-directed agents should not be utilized in clinical practice at this time', MedPage 7/20/23

Posted without comment for the SOC crowd. Emmanuel Antonarakis, MD, on Dual Androgen Receptor Inhibition in Metastatic Castration-Resistant Prostate...

Posted without comment for the SOC crowd. Emmanuel Antonarakis, MD, on Dual And...

•9 months ago

declining n stable psa

Hello ladies n gentleman, I am posting my latest psa results, solely on ivermectin cbd turmeric n zinc. Psa has dropped or remained stable for the last 5...

Hello ladies n gentleman, I am posting my latest psa results, solely on ivermect...

•9 months ago

Senescent neutrophils and their subsequent impact on tumor progression and therapy resistance

I will comment after studying this for awhile, but it does open up an additional treatment path(s?) for PCa. (Excerpts) Calcinotto's team discovered that...

I will comment after studying this for awhile, but it does open up an additional...

•9 months ago

Catabolic Wasting, Cachexia and Sarcopenia - Life Extension Foundation, Section Update: 03/2021

As most men with PCa are oldER and may be on some form of testosterone-blocking treatment, like ADT, odds are they are also struggling with the muscle-wasting...

As most men with PCa are oldER and may be on some form of testosterone-blocking ...

•9 months ago

Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance, Int J Mol Sci. 2022 Nov; 23(21): 13521

This is by far the best overview paper I have seen on the topic of AR metabolism and the nature of treatment resistance for mainstream SOC drugs currently in...

This is by far the best overview paper I have seen on the topic of AR metabolism...

•9 months ago

Reminder - Webinar -Let's Talk Alpha #PSMA and New Theranostic Targets

Professors Declan Murphy and Michael Hoffman from Peter MacCallum Cancer Centre, Dr Howard Soule and Dr Andrea Miyahira will be holding a live webinar with...

Professors Declan Murphy and Michael Hoffman from Peter MacCallum Cancer Centre,...

•9 months ago

1yr update on Daro, Orgo, Osterine, and Carderine

i posted an update on this after 9 months and all was well with my PSA, T and my liver panel CMP numbers were all in the green. So this is my 1 year update...

i posted an update on this after 9 months and all was well with my PSA, T and my...

•10 months ago

Albumin

New paper below [1]. About 18 years ago, a man who headed a PCa group in CA told me to forget PCa-related markers - the best indicator that a man wouldn't...

New paper below [1]. About 18 years ago, a man who headed a PCa group in CA t...

•10 months ago

Irrational emotional mood swings on ADT

I have recently had some irrational emotional mood swings . I had a similar experience about 6 months ago, they went away within the week. I did not equate it...

I have recently had some irrational emotional mood swings . I had a similar expe...

•10 months ago

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The CRP:Albumin ratio & CRPC Survival

New paper from Portugal below [1]. Here is another study showing the consequences of subclinical inflammation. The inflammation markers used were...

New paper from Portugal below [1]. Here is another study showing the conseque...

•10 months ago

Trial drug. ARV-766

I started my phase 1/2 trial today and was curious if there were anyone anyone else in this group with any experience with this Protac treatment. Rumor is,...

I started my phase 1/2 trial today and was curious if there were anyone anyone e...

No_stone_unturned

•10 months ago

Checkpoint inhibitor after PARPi - anybody?

I have been on Olaparib for 2 years, but PSA is rising. We know PARPi upregulates PD-L1 - thus priming the cells? Has anybody tried Pembro after Olaparib?

I have been on Olaparib for 2 years, but PSA is rising. We know PARPi upregulate...

•10 months ago

Thromboxane & Aspirin

New British study below [1]. "Pre-clinical models demonstrate that platelet activation is involved in the spread of malignancy." (Metastasis is dependent...

New British study below [1]. "Pre-clinical models demonstrate that platelet a...

•10 months ago

Ravid Straussman & the Tumor Biome

I was reading an article about the tumor biome, and how bacteria & fungi may have a role in treatment resistance. I thought it might be interesting to review...

I was reading an article about the tumor biome, and how bacteria & fungi may hav...

•10 months ago

Dose titration for CRPC

Hi For those of us who question why we should recieve the Maximum Tolerated Dose as opposed to a Minimum Effective Dose, the work of the Moffitt among others...

Hi For those of us who question why we should recieve the Maximum Tolerated Dose...

•10 months ago

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