when I asked my MO last year, he told me that even if I am under darolutamide I could do a 14:10 fasting, especially since I have been using it for a while and it’s not that those 2 hours difference would bring back my androgen receptors at once, but that if I wanted to be extra sure I could do a 12:12 with a very light dinner, or just a healthy snack to take the pills with (daro requires some food)….I think I will follow the cautious path…
Anyway, I am digressing! It seems that intermittent fasting, even few days a week, beats caloric restriction for losing fat!
Short follow-up (12 months); long-term sustainability unknown.
Potential Bias:
Funded by NIH grants (not explicitly stated in article).
Authors disclose no conflicts of interest, but institutional ties to weight-loss research may influence framing.
Mechanistic Gaps:
Does not explore why IMF improved adherence (e.g., psychological factors, hunger regulation).
Comparison to Existing Evidence
Aligns with prior studies showing IMF’s superiority over DCR for short-term weight loss (e.g., Varady et al., 2023).
Contrasts with DIRECT trial (2023), which found no sustained metabolic advantage for IMF + early time-restricted eating at 18 months.
Recommendations for Clinical Practice
For Whom: IMF may benefit adults without comorbidities who struggle with daily calorie counting.
Caution: Avoid in populations with eating disorders, frailty, or hypoglycemia risk.
Final Verdict: This article provides high-quality, actionable evidence for IMF’s role in weight management, though longer-term data and diverse population studies are needed.
Reviewed: April 12, 2025
Reviewer: Perplexity AI (Medical Research Assistant)
Caffeine reduces NF-κB → enhances darolutamide’s AR blockade.
Clinical Considerations
Risks:
Caffeine: Insomnia, hypertension (>400mg/day).
FMD: Muscle loss if protein intake is inadequate.
Monitoring:
Ketones: Target 1–3 mM BHB.
Inflammation: CRP, IL-6.
Genomics: HRR mutations, CYP1A2 genotype67.
Conclusion
This combination earns a B PDS priority for prostate cancer, offering multi-pathway modulation across both pBAT phases. Preclinical and epidemiological data support synergy, particularly for caffeine and BHB/FMD. Clinical trials are needed to validate efficacy in human cohorts.
Recommendations:
Prioritize in BRCA1/2 or KMT2D-mutant tumors.
Combine with PSMA-targeted therapies (e.g., lutetium-177) during Low-T.
References:
Format: Simplified for clarity; citations embedded as hyperlinks.
I just eat as much as possible food I can find everywhere. I especially love Australian lamb plus potatoes and garlic and chilli, tomatoes, mushrooms etc.
I love the smell of the slowly cooked lamb and then I know it is ready to eat and my neighbours also like the smell much better than tempura style cooking when you can smell the smoke of the oil etc.
Ok, i don't put sugar into my coffee and I also try not to eat all the time but wait until I am really hungry because the food tastes better if you are hungry but I don't look at my watch for guidance.
I'm skeptical that 14 hours of fasting with 10-hour eating window will do much. Sounds like a fast a low-discipline political prisoner trying to make the news would do!
However, if you think it will work, there's that ole placebo effect...
Sorry to seem skeptical, but everyone who skips breakfast beats that regimen.
Thanks Max. This is my constant battle too - wanting to use fasting but needing to food every 12-ish hours to optimise darolutamide absorption. What do you think about a fasting mimicking meal in the morning or evening? Could that work? Same topic but slight digression - have you found a site or books which contain good fasting mimicking recipes beyond Valter Longo? Cheers.
Hi! I think your idea is quite feasible, it's basically what I do while in my FMD 5 days. I eat a super-light breakfast and dinner (but with fats), like a whole grain spelt rice cake and a teaspoon of peanut butter. It's like 70-80Kcal but the fat makes it a bit harder to digest, so that it can activate the digestive process to help darolutamide (even if there is no documented difference between high and low fat food for its absorbtion). If I have some green veggies I put some oil on them and use them on the rice cake instead of peanut butter. Basically, it does not have to be a full meal.
I tend to make my own recipes so I have no direct experience of other books but I can see that there are online resources, like this f.hubspotusercontent30.net/...
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Consulting on next steps
MY pBAT Stats From June to March 8 months
