Curcumin as an immunomodulator

[PCaWarrior]

I looked at this specifically for BAT. SPA might synergize with immunomodulators. As it often happens, I can't get the drugs that are powerful immunomodulators. So I look for natural substances. Usually orders of magnitude weaker but you do what you need to do.

I'm going to try this out during SPA. ATRi is a positive, and senolytic is a negative. So... two pluses and one minus = 1

I'm going to try 6-8g a day. rBAT is only hours or at most a few days so might be good with that. not sure if I'll have gastro issues taking that much for more than a few days.

Once again, I apologize for the weak formatting. FYI: ten clinical trials for curcumin and PCa. 4 are recruiting.

BAT + nivolumab has been trialed. clinicaltrials.gov/ct2/show...

Nivo is an immunomodulator/immune checkpoint inhibitor/PD-L1 inhibitor.

Curcumin as an Immunomodulator in Prostate Cancer: Analysis

Dose, Evidence, Efficacy, and Mechanistic Theory

Aspect Details

Dose 200–8,000 mg/day orally (preclinical: 200–2,000 mg/kg in animal models; clinical: 1,000-8,000 mg/day in phase II trials).

Efficacy (A-F) B: Preclinical synergy with anti-PD-1 agents; limited clinical validation in prostate cancer.

Evidence (A-F) B: Strong preclinical data (STAT3 inhibition, PD-L1 downregulation); moderate human trial data (phase II with docetaxel).

Mechanistic Theory (A-F) A: Inhibits STAT3, reduces PD-L1 expression, converts Tregs to Th1 cells, enhances dendritic cell function.

Mechanisms of Action

1. STAT3 Inhibition: Directly binds to cysteine 259 on STAT3, suppressing IL-6/IL-8 and PD-L1 expression.

2. PD-L1 Downregulation: Reduces PD-L1 on tumor cells, blocking PD-1/PD-L1 interaction and enhancing T-cell cytotoxicity.

3. Immune Modulation: Converts immunosuppressive Tregs to anti-tumor Th1 cells, increases CD8+ T-cell infiltration, and inhibits MDSCs.

Synergy with BAT’s PSA Phase

BAT Phase Curcumin’s Role

High Androgen (PSA Rise) Curcumin reduces IL-6 (linked to STAT3 activation), mitigating androgen-driven inflammation and enhancing T-cell activity against DNA-damaged tumor cells.

Low Androgen Curcumin’s anti-inflammatory effects may reduce resistance to darolutamide/Zytiga by suppressing NF-κB and AR signaling.

Reference List

Rating (A-F) Article Title URL

B Curcumin as an Adjuvant to Cancer Immunotherapy pmc.ncbi.nlm.nih.gov/articl...

A Curcumin interacts directly with the Cysteine 259 residue of STAT3 to inhibit constitutive activation nature.com/articles/s41598-...

B The potential role of curcumin in prostate cancer tcr.amegroups.org/article/v...

B Application and potential value of curcumin in prostate cancer frontiersin.org/journals/ph...

B Combination of curcumin and bicalutamide enhanced growth inhibition in prostate cancer pmc.ncbi.nlm.nih.gov/articl...

 

[Professorgary]

I have read much about curcumin and use 2800mg daily. As far as it’s effect on fighting prostate cancer, I have not a clue. I mainly take curcumin, berberine and magnesium for ADT side effect mitigation and heart protection. In my clinical trial of one it has worked beautifully. I also measure my water intake and shoot for at least 72ozs of non caffeinated intake. Of interest, my kidney function has always been pretty good ranging in the high 80s to low 90s. After being on curcumin that number went up to 117. The adt started to raise my glucose to 120 to 140 non fasting and berberine brought that down to 99 after 6 weeks and 93 4 weeks later, non fasting. Bp is great as well.

Now since you mentioned curcumin to fight prostate cancer why not check out berberine and it’s effect on ACR1c3 expression. This is very important if switching from prednisone to dexamethasone as if this is over expressed it lessens the chance for success upon switching.

[PCaWarrior in reply to Professorgary]

I'll look into Berberine for the effect you mention. Overall it's evidence, like most supplements, is rather weak. But okay and if I was diabetic or pre-diabetic maybe I'd take it.

You take curcumin. Do you also take sulforaphane, EGCG, Pomegranate, or lycopene?

synergist sups

[Professorgary in reply to PCaWarrior]

No I don’t take any of the supplements you mentioned. And yes the evidence is weak which is why I rely on my one man clinical trials.lol

[PCaWarrior in reply to Professorgary]

Perhaps the evidence is good for Berberine repressing enzymatic activity of ACR1c3. I frequently need to get into the weeds instead of the general: does "x" help PCa patients.