Posts - Fight Prostate Cancer | HealthUnlocked

Fight Prostate Cancer

2,956 members•1,313 posts

All posts for June 2023

c-myc

Further to the "Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM...

Further to the "Supraphysiological Androgens [SPA] Promote Tumor Suppressive Act...

•2 years ago

Baicalin & Stem-Like PCa cells

New study below [1]. “Baicalin Antagonizes Prostate Cancer Stemness via Inhibiting Notch1/NF-κB Signaling Pathway” Baicalin is one of the active...

New study below [1]. “Baicalin Antagonizes Prostate Cancer Stemness via Inhibit...

•2 years ago

No Increase in Major Cardiac Events With Testosterone-Replacement Therapy, MedPage Today, June 16, 2023.

This is a post I started a week ago - and Patrick's post earlier today on Supraphysiological Androgens effects on tumor suppression has given me the impetus to...

This is a post I started a week ago - and Patrick's post earlier today on Suprap...

•2 years ago

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Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM Complex

New study [1]. I have struggled to understand how Denmeade’s BAT (Bipolar Androgen Therapy) depends on supraphysiological levels of androgen (testosterone =...

New study [1]. I have struggled to understand how Denmeade’s BAT (Bipolar Andr...

•2 years ago

Androgens & colorectal cancer

Interesting new Swedish study below [1]. “To assess whether androgens play a role in explaining the sex related differences in the incidence of colorectal...

Interesting new Swedish study below [1]. “To assess whether androgens play a r...

•2 years ago

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Cytoreductive Prostatectomy & Oligometastatic PCa.

New meta-analysis below [1]. The day that I had a prostatectomy, my surgeon had another operation. The man was found to have cancer in a lymph node, so was...

New meta-analysis below [1]. The day that I had a prostatectomy, my surgeon had...

•2 years ago

Any tips for lowering AST (liver enzyme score)

The bottom line/question up front: Does anyone have recommended supplements, which might lower the AST level, or know of specific supplements that should...

The bottom line/question up front: Does anyone have recommended supplements, whi...

•2 years ago

My reaction to Crestor & Nubeqa combo. I need to make some adjustments. This study says simvastatin is best against APC. Your thoughts?

Based on these studies, do you think it's best to use simvastatin as your choice of statins? I'm using Crestor 5 mg plus 5mg Zetia and my ldl has gone down to...

Based on these studies, do you think it's best to use simvastatin as your choice...

•2 years ago

OVM 200 clinical trial on TV

https://www.newscientist.com/article/2375922-advancing-immunology-the-future-of-vaccine-innovations/ at 6.25 mins is a bit of info about the trial I...

https://www.newscientist.com/article/2375922-advancing-immunology-the-future-of-...

•2 years ago

Let's Talk Alpha #PSMA and New Theranostic Targets

Professors Declan Murphy and Michael Hoffman from Peter MacCallum Cancer Centre, Dr Howard Soule and Dr Andrea Miyahira will be holding a live webinar with...

Professors Declan Murphy and Michael Hoffman from Peter MacCallum Cancer Centre...

•2 years ago

Cheese

New umbrella study of cheese & health outcomes [1]. The authors are Chinese – with the exception of Edward Giovannucci. A PubMed search for returned 20...

New umbrella study of cheese & health outcomes [1]. The authors are Chinese –...

•2 years ago

Requesting Help to Develop Bespoke BAT

Brief history. Diagnosed in July 2020 with oligometastatic PC with PSA 1,600… picked at 13,000+ after biopsy, Gleason 8. One previous bone femur lesion (...

Brief history. Diagnosed in July 2020 with oligometastatic PC with PSA 1,600… pi...

•2 years ago

Serum Essential Elements and Survival after Cancer Diagnosis

New Polish-Canadian study below [1]. The elements were selenium (Se), zinc (Zn) and copper (Cu). "In a prospective study, we measured the associations...

New Polish-Canadian study below [1]. The elements were selenium (Se), zinc (Zn)...

•2 years ago

Pembrolizimumab after Olaparib - ICI after PARPi + BAT

There are very good results, it seems that prolonged use of Olaparib upregulates PD-L1 to a high extent. Has anybody tried Pembro after Olaparib?...

There are very good results, it seems that prolonged use of Olaparib upregulates...

•2 years ago

ASCO 2023 summed up in 8 minutes

https://www.urologytimes.com/view/aua-2023-dr-stratton-discusses-prostate-cancer-research?utm_source=sfmc&utm_medium=email&utm_campaign=06072023_UT_BAY-23-URV01

https://www.urologytimes.com/view/aua-2023-dr-stratton-discusses-prostate-cancer...

•2 years ago

Enzalutamide & ARCHES trial.

More from ASCO 2023 [1]: “We found in ARCHES that in the men who developed radiographic progression while on ADT-enzalutamide [Xtandi], two thirds of these...

More from ASCO 2023 [1]: “We found in ARCHES that in the men who developed radi...

•2 years ago

Enzalutamide & 5-year survival in mHSPC.

More from ASCO 2023 [1] [2]. "Patients in the ENZAMET trial (n = 1125) were randomized 1:1 to arm A, the control arm consisting of TS plus a standard...

More from ASCO 2023 [1] [2]. "Patients in the ENZAMET trial (n = 1125) were ran...

•2 years ago

Darolutamide & time to treatment discontinuation in nmCRPC

Further to the recent Apalutamide thred, we now have [1]: "A real-world analysis of the androgen receptor inhibitors (ARIs) darolutamide (Nubeqa),...

Further to the recent Apalutamide thred, we now have [1]: "A real-world analysi...

•2 years ago

A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation, eLife, Review Article, Mar 23, 2023

For those wanting to do a deep dive into Adaptive Theory, this survey paper is the current master document to do so. It includes the major researchers...

For those wanting to do a deep dive into Adaptive Theory, this survey paper is ...

•2 years ago

Any advice on LU 177?

I don't know if I'll be a candidate for the procedure because of kidney issues, but I still want to make an informed decision between that and risk bone...

I don't know if I'll be a candidate for the procedure because of kidney issues, ...

•2 years ago

Apalutamide vs Abiraterone for Deep PSA Response in MHSPC patients

Salutations FPC'ers, New retrospective study from MD Anderson for ASCO 2023 evaluating the 2 ARPI drugs for deep PSA response in hormone sensitive patients....

Salutations FPC'ers, New retrospective study from MD Anderson for ASCO 2023 eva...

•2 years ago

The association between serum lipid profile and the prostate cancer risk and aggressiveness

New study from Korea [1]. "Men who underwent prostate biopsy between January 2005 and December 2015 were retrospectively analyzed. The association between...

New study from Korea [1]. "Men who underwent prostate biopsy between January 20...

•2 years ago

FDA approves olaparib/abiraterone for BRCA-positive mCRPC

https://www.urologytimes.com/view/fda-approves-olaparib-abiraterone-for-brca-positive-mcrpc?utm_source=sfmc&utm_medium=email&utm_campaign=05312023_UT_BREAKINGNE

https://www.urologytimes.com/view/fda-approves-olaparib-abiraterone-for-brca-pos...

•2 years ago

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