Posts - Fight Prostate Cancer | HealthUnlocked

Fight Prostate Cancer

2,956 members•1,313 posts

All posts for January 2025

Preclinical: hydrogel to help with immune therapy

A novel lipopeptide hydrogel delivery system could improve peptide-based cancer vaccines, providing a dual approach by acting as both a delivery platform and...

A novel lipopeptide hydrogel delivery system could improve peptide-based cancer ...

•24 hours ago

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Preclinical: EcDNA in Prostate Cancer

Researchers found that androgen receptor (AR) extrachromosomal DNA (EcDNA) is a key factor in treatment resistance for advanced prostate cancer. AR EcDNA leads...

Researchers found that androgen receptor (AR) extrachromosomal DNA (EcDNA) is a ...

•24 hours ago

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CaRe trial expanded to veterans

A clinical trial for INKmune immune therapy, focused on metastatic castration-resistant prostate cancer, expanded to include veterans at the West Los Angeles...

A clinical trial for INKmune immune therapy, focused on metastatic castration-re...

•24 hours ago

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WNT9B gene mutation can predict higher prostate cancer risk

Researchers identified a mutation in the WNT9B gene linked to significantly higher prostate cancer risk. Studies across multiple populations confirmed this...

Researchers identified a mutation in the WNT9B gene linked to significantly high...

•24 hours ago

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news are coming...

I hope they will be good ones...I will be following this symposium and try to report back as usual......

I hope they will be good ones...I will be following this symposium and try to re...

•2 days ago

Which research would I fund?

Hi! I got an interesting question from one of you guys, and I think it could be an interesting topic for us all. What kind of research would you fund ?(if you...

Hi! I got an interesting question from one of you guys, and I think it could be...

•3 days ago

Newsletter number 4 is out!

Check your spam folder if you have received nothing in your inbox! Of course if you are registered for the newsletter....if you are not, what are you waiting...

Check your spam folder if you have received nothing in your inbox! Of course if...

•4 days ago

Digoxin helps combat the spread of metastases

A new study published in Nature Medicine has shown that the heart drug digoxin can help combat metastasis by reducing the size of tumor cell clusters, which...

A new study published in Nature Medicine has shown that the heart drug digoxin c...

•5 days ago

Phase 1 soon recruiting: another AI designed drug

We will see....but if it performs well, man, it's another proof of the concept. For example, check a company called InSilico and you will see how many big...

We will see....but if it performs well, man, it's another proof of the concept. ...

•6 days ago

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Phase 1/2 trial: evofosfamide + zalifrelimab + balstilimab

A new clinical trial is evaluating whether the combination of evofosfamide, a hypoxia-activated drug, with checkpoint inhibitors zalifrelimab and balstilimab...

A new clinical trial is evaluating whether the combination of evofosfamide, a hy...

•6 days ago

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Update on OP-3136 Phase 1 clinical trial

The clinical trial just started: https://clinicaltrials.gov/study/NCT06784193 I have already written about this here:...

The clinical trial just started: https://clinicaltrials.gov/study/NCT06784193 I...

•6 days ago

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AAA817 (225Ac-PSMA-617) phase 2/3 trial

The PSMAcTION trial is a Phase II/III open-label, multicenter study evaluating the investigational drug AAA817 (225Ac-PSMA-617) for PSMA-positive metastatic...

The PSMAcTION trial is a Phase II/III open-label, multicenter study evaluating t...

•6 days ago

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Phase 1 clinical trial of IPH4502

A new clinical trial is exploring the potential of IPH4502, an antibody-drug conjugate (ADC) targeting Nectin-4, in patients with advanced solid tumors....

A new clinical trial is exploring the potential of IPH4502, an antibody-drug con...

•6 days ago

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Oncolytic virus strikes again

Ok it's the Daily Mail, but I have checked also other sources 😜 A groundbreaking study used a modified Newcastle disease virus, known as NDV-GT, to target...

Ok it's the Daily Mail, but I have checked also other sources 😜 A groundbreaki...

•6 days ago

BOOM! A first huge AI attempt at accelerating drug development

Remember when I talked about AI being more and more prominent in drugs development? Ok, here is a first huge attempt from Google (there are many smaller...

Remember when I talked about AI being more and more prominent in drugs developme...

•7 days ago

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News from white button mushrooms!

Do you remember the article I posted about the research on white button mushrooms slowing down PCa? (I must be careful because I keep writing white bottom!) ....

Do you remember the article I posted about the research on white button mushroom...

•7 days ago

Repurposing: antipsychotic drugs for cancer

Or maybe they won't help with it, but we would not care! 😜😜 Repurposing antipsychotic drugs offers a promising, cost-effective approach to cancer treatment....

Or maybe they won't help with it, but we would not care! 😜😜 Repurposing antip...

•8 days ago

Just an idea/poll

Hi! I had an idea floating in my head for a while, and I am now starting to perfect it (talking to lawyers, finding founders and so on). After talking and...

Hi! I had an idea floating in my head for a while, and I am now starting to per...

•9 days ago

Can't always win: LAVA-1207 trial discontinued (I suppose for financial reasons)

My feeling is...it worked but not well enough to justify further development (financially), because there are some enrolled patients who had stable disease...

My feeling is...it worked but not well enough to justify further development (f...

•9 days ago

an interesting summary

Just to have all (or almost all) the non SOC supplements and similar summarized in two sources: https://www.nature.com/articles/s41392-020-00213-8...

Just to have all (or almost all) the non SOC supplements and similar summarized ...

•10 days ago

Just a thought

40% of phase 1 clinical trials fails because of lack of enrolled patients....this is something I did not expect.......

40% of phase 1 clinical trials fails because of lack of enrolled patients....thi...

•11 days ago

Newsletter number 3 is out!

....and you should have received it! Have a great Sunday! Max

....and you should have received it! Have a great Sunday! Max

•11 days ago

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PARP inhibitors: general consensus

PARP inhibitors have emerged as a targeted therapy for prostate cancer, especially in tumors with specific DNA repair defects. By exploiting synthetic...

PARP inhibitors have emerged as a targeted therapy for prostate cancer, especial...

•12 days ago

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E2 patch during ADT is helping a lot!

First off, a status of my situation: I am hormone sensitive and have been doing BAT myself using different testosterones at times. Been doing BAT for 16...

First off, a status of my situation: I am hormone sensitive and have been doing...

•13 days ago

Update: CLS-1025 moves to phase 1 trial for p53 mutation

Ok, today it's the 17th, they were expected to start the trial in jan 2025 and they are not yet recruiting, but the trial is there! Preclinical data highlight...

Ok, today it's the 17th, they were expected to start the trial in jan 2025 and t...

•13 days ago

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Preclinical: Will bacteria save us?? A new amazing tool!

Researchers at UMass Amherst have developed BacID, a bacteria-based cancer therapy that uses genetically engineered, non-toxic Salmonella to target tumors and...

Researchers at UMass Amherst have developed BacID, a bacteria-based cancer thera...

•14 days ago

OTC medication safe with BPH

Recently, I took Nyquil for flu symptoms, and it led to complications:-( I looked at the medication box and clearly says can lead to complications with...

Recently, I took Nyquil for flu symptoms, and it led to complications:-( I looke...

•15 days ago

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Great PSA results and going back on cBAT

As you know from my recent BAT posts I had to stop due to Kidney Stones, gout and high uric acid at 5.6 along with a big spike in PSA from 1.4 to 6.36 in 30...

As you know from my recent BAT posts I had to stop due to Kidney Stones, gout an...

•15 days ago

Preclinical: New PROTAC for mCRPC

A novel PROTAC targeting the ERG protein is being developed to address metastatic castration-resistant prostate cancer (mCRPC). ERG gene fusions, found in up...

A novel PROTAC targeting the ERG protein is being developed to address metastati...

•15 days ago

Phase 1 trial: VIR-5500 t-cell engager

The amount of t-cell engagers that are being developed is increasing more and more. Do they know something that we don't? 😱 VIR-5500 is a novel dual-masked...

The amount of t-cell engagers that are being developed is increasing more and mo...

•16 days ago

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