New labs after abstaining from all(!) supplements for a month. Previous tests were done after only eight days and therefore meaningless

[Noelnoel]

In my last post about my results, after abstaining from ALL supplements for about eight days, including metavive and adrenavive (whole bovine/porcine gland and whole adrenal gland respectively) I had blood tests and reported the following:

Ft3 4.6 pmol/L (3.5 - 6.5)

TSH mU/L< 0.03 (0.35 - 5.5)

Ft4 13.1 pmol/L (10.5 -21.0)

Ferritin 79.0 ug/L (10.0 - 291.0)

B12 482.0 ng/L (211.0 - 911.0)

D3 114 nmol (30.0 - 50.0)

Folate 17.44 ug/L (> 5.38)

Rightly, you pointed out that this wasn’t enough time (endo agreed) and suggested it be a month. This I did and below are the results from the tests on 16/08/20

What I was trying to establish is what exactly my hormones are doing without any assistance whatsoever. You’ll see that one of the liver enzymes is abnormal and that serum cortisol taken at 9.05am is very high (is there an association between high cortisol and that particular liver enzyme and did I read somewhere about liver disease in thyroid patients?)

I should add, I have a saliva cortisol (CAR) test in a box waiting to be done on Monday because I know it’s important to see what the adrenals are doing over the course of a whole day. The test involves saliva taken immediately upon waking, then 30 mins later and then 60 mins later. Altogether, it’s six saliva samples. This, I’ll present to the endo to compare to the serum 9am cortisol she had me do

What I’d like advice on please, is, we know I have Hashi’s and now we know my natural state without assistance from supplements. So, going forward I’m open to suggestions as to what I need to be taking and dosages. Obviously my aim is to become optimal and what that would mean to me is:

Ditching my insomnia

Ditching the weight

Regaining my zest for life

Feeling well in general

Now, whether this means continuing with metavive or switching to NDT or conventional pharmaceuticals, I’d love to hear what you have to say, (telling me why, is always helpful too) including your advice on nutritional supplements

The following are results from a year ago when I was in the thick of taking nutritional and thyroid supplements:

Ft3 3.8 pmol/L (3.5 - 6.5)

TSH 4.95 mU/L (0.27 - 4.2)

Ft4 10.2 pmol/L (12 - 22)

And the following are my results from Tuesday. You’ll see my TP0ab is very high. Well, high for me as it’s usually between 43 and 168. Does this mean that at this precise time, my thyroid is under attack? You will also see that the lab reference ranges have changed. One is Lister refereced and the other Addembrookes

I hope this post isn’t too muddled but if so, please do ask me questions for clarification. The following was copied and pasted:

Serum thyroid peroxidase antibody concentration 267 iu/ml [0.0 - 60.0]

Serum free triiodothyronine level 4.4 pmol/L [3.5 - 6.5]

Serum gamma-glutamyl transferase level 109 u/L [0.0 - 37.0]

Serum albumin level 41 g/L [35.0 - 50.0]

Serum total bilirubin level 9 umol/L [0.0 - 20.0]

Serum alkaline phosphatase level 70 U/L [30.0 - 130.0]

Serum alanine aminotransferase level 46 U/L [10.0 - 49.0]

Serum TSH level 8.09 mU/L [0.35 - 5.5]

Serum free T4 level 9.4 pmol/L [10.5 - 21.0]

A 09:00 am cortisol of >374nmol/L excludes adrenal insufficiency providing the patient has not had recent exposure to exogenous oral steroid or oral oestrogen (OCP, HRT).

Serum cortisol level 659 nmol/L

Above high reference

[greygoose]

The following was copied and pasted. Hope that’s ok

Very bad idea because you get too much meaningless verbage. All we want is:

Test name result (range)

You’ll see my TP0ab is very high. Well, high for me as it’s usually between 43 and 168. Does this mean that at this precise time, my thyroid is under attack?

Not necessarily. If your thyroid had just been attacked, the FT4 and FT3 would be a lot higher. Can't even find the TPOab result amongs all those words.

The most obvious thing that jumps out is your TSH is much too high and you are hypo.

[Noelnoel in reply to greygoose]

Thank you gg, I’ll edit

[greygoose in reply to Noelnoel]

You're welcome.

[Noelnoel]

Ha ha. Yes, I did it. Thank you for your offer of help

[SlowDragon Administrator]

It can 6-8 weeks for TSH to respond

You have Hashimoto’s...your thyroid is failing

On no thyroid hormones likely your vitamin levels are diving down

[Noelnoel in reply to SlowDragon]

Yes, highly likely and I will resume vitamins soon before they get too low but what I’m really interested in now is what next with thyroid replacement

[SlowDragon Administrator in reply to Noelnoel]

What have you tried

Levothyroxine initially - slowly increases upwards until on full replacement dose

(plus small doses T3 along side if Ft3 remains too low)

often need to try different brands until find one that suits best

[Noelnoel in reply to SlowDragon]

Have only used metavive and if I could find a practitioner who could guide me with it, I think I’d try that again. Or NDT, do you know anything about it? What I’m looking for is something with as few fillers as possible. I like to keep things as natural s possible wherever I can. I seem to be sensitive to all sorts of things

[SlowDragon Administrator in reply to Noelnoel]

Levothyroxine (plus T3 if needed) is most adaptable

All medications have fillers. Active ingredients are minuscule percentage of any tablets

[Noelnoel]

Thank you

So, with my numbers as they are currently, if you were my endo, how would our consultation go and what advice would I walk out of your surgery with? No need to answer now, I appreciate it’s a Sunday. Any day will do. Very grateful for your input so far