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Promising Clinical Activity of Cabozantinib + ADT in Hormone-Naïve Metastatic Prostate Cancer
TAKE-HOME MESSAGE •Cabozantinib is a small-molecule inhibitor of c-MET/VEGFR2 signaling that has yielded improved progression-free survival but not overall survival in patients with metastatic castrate-resistant prostate cancer (mCRPC). Based on preclinical data, the authors hypothesized that cabozantinib
TAKE-HOME MESSAGE •Cabozantinib is a small-molecule inhibitor of c-MET/VEGFR2 signaling that has yielded improved progression-free survival but not overall survival in patients with metastatic castrate-resistant prostate cancer (mCRPC). Based on preclinical data, the authors hypothesized that cabozantinib
Denver, Colorado, USA suggestions for referral to do bone marrow biopsy
Greetings, all. I am looking for suggestions on providers in the Denver area to perform a bone marrow biopsy to "rule out other malignant pathology." In a post of mine entitled "Let's talk lytic lesions" that discussed my consistently low alkaline phosphatase (ALP) despite numerous identified bone
Greetings, all. I am looking for suggestions on providers in the Denver area to perform a bone marrow biopsy to "rule out other malignant pathology." In a post of mine entitled "Let's talk lytic lesions" that discussed my consistently low alkaline phosphatase (ALP) despite numerous identified bone
Let's talk lytic lesions...
Good day to you wherever you may be. I'm seeking to get feedback on folks' experiences with lytic bone lesions specifically. As background, although bone metastasis with APCa is very common, lytic bone tumors (i.e., destructive type) have been touted in the literature as being less common than sclerotic
Good day to you wherever you may be. I'm seeking to get feedback on folks' experiences with lytic bone lesions specifically. As background, although bone metastasis with APCa is very common, lytic bone tumors (i.e., destructive type) have been touted in the literature as being less common than sclerotic
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Question on Alkaline phosphatase
On lupron and zytiga, after 19 months PSA went from 1230 to 0.08, Alkaline phosphatase went from 782 to 109 but then ALP increased to 169. My question is can that ALP increase be attributed to bone healing or only to cancer activity?
On lupron and zytiga, after 19 months PSA went from 1230 to 0.08, Alkaline phosphatase went from 782 to 109 but then ALP increased to 169. My question is can that ALP increase be attributed to bone healing or only to cancer activity?
Xtandi working
My husband is finally getting his PSA down with Xtandi. It went from 60 to 18. His testosterone has gone up to a normal range, since he is only taking Xtandi. What surprised me is that despite his testosterone going up -it's 6- his Psa lowered and also his alkaline phosphatase lowered from 1000 to
My husband is finally getting his PSA down with Xtandi. It went from 60 to 18. His testosterone has gone up to a normal range, since he is only taking Xtandi. What surprised me is that despite his testosterone going up -it's 6- his Psa lowered and also his alkaline phosphatase lowered from 1000 to
Talapro2 8 weeks later
PSA dropped to .4, scans show no progression with 2 mets to ribs not showing. Also Alkaline Phosphatase down to 138. My MO is very pleased with results. So am I.
PSA dropped to .4, scans show no progression with 2 mets to ribs not showing. Also Alkaline Phosphatase down to 138. My MO is very pleased with results. So am I.
Trip to West Africa
Hello everyone! I need your advice please. Has anyone travelled to Africa since diagnosed? I'm planning a trip to Senegal and I need a few vaccines (yellow fever, diphtheria, tetanus, polio, hepatitis A) and also the malaria tablets. Is it too risky for me to travel there and have all these vaccines?
Hello everyone! I need your advice please. Has anyone travelled to Africa since diagnosed? I'm planning a trip to Senegal and I need a few vaccines (yellow fever, diphtheria, tetanus, polio, hepatitis A) and also the malaria tablets. Is it too risky for me to travel there and have all these vaccines?
Retreatment With Radium-223 in Patients With Castration-Resistant Prostate Cancer and Bone Metastases
TAKE-HOME MESSAGE •Radium-223 is approved for patients with castration-resistant prostate cancer and symptomatic bone metastases. Repeat treatment after initial therapy has not been studied. The authors studied 44 patients who completed an initial course of six Xofigo treatments without progression
TAKE-HOME MESSAGE •Radium-223 is approved for patients with castration-resistant prostate cancer and symptomatic bone metastases. Repeat treatment after initial therapy has not been studied. The authors studied 44 patients who completed an initial course of six Xofigo treatments without progression
Low DRVVT?
Hello everyone! I recently had some labs done & although my doctor was looking for high lab results (I assume), most of my labs came back lower than the recommended range. My labs that were lower than normal included: DRVVT, ALT, Creatine & Alkaline Phosphatase. Has anyone else had any similar labs and
Hello everyone! I recently had some labs done & although my doctor was looking for high lab results (I assume), most of my labs came back lower than the recommended range. My labs that were lower than normal included: DRVVT, ALT, Creatine & Alkaline Phosphatase. Has anyone else had any similar labs and
Routine alkaline phosphatase and bone specific alkaline phosphatase
Should I go for a bone specific
alkaline
phosphatase
test
. Is there any chance for the bone specific
alkaline
phosphatase
level to be higher when the normal liver function
test
alkaline
phosphatase
level is normal.
Should I go for a bone specific
alkaline
phosphatase
test
. Is there any chance for the bone specific
alkaline
phosphatase
level to be higher when the normal liver function
test
alkaline
phosphatase
level is normal.
High Thyroglobulin blood results
showed high
Alkaline
Phosphatase
.
showed high
Alkaline
Phosphatase
.
Ratio of periprostatic to subcutaneous fat thickness on MRI is an independent survival predictor in hormone-naïve men with advanced PCa
New study from Japan [1]. Visceral fat is associated with a poorer prognosis. Visceral fat is hormonally active (& not in a good way.) Many researchers who have reported on obesity & PCa mortality, acknowledge that BMI (body mass index) is a surrogate for visceral fat. However, one can be thin outside
New study from Japan [1]. Visceral fat is associated with a poorer prognosis. Visceral fat is hormonally active (& not in a good way.) Many researchers who have reported on obesity & PCa mortality, acknowledge that BMI (body mass index) is a surrogate for visceral fat. However, one can be thin outside
well...home from Holiday...AND, In spite of the Foley catheter and a few other set backs along the way...made it the whole 5 weeks.
Did Everything, ate everything, saw everything...across 2100 miles by car...1100 miles by Motorcoach Guided Tour with Gate1...1100 miles by Train (Scenic California Zephyr) and ended up in Sacramento for a four day visit with a friend there (and rest before the flight home to Ft. Lauderdale). I really
Did Everything, ate everything, saw everything...across 2100 miles by car...1100 miles by Motorcoach Guided Tour with Gate1...1100 miles by Train (Scenic California Zephyr) and ended up in Sacramento for a four day visit with a friend there (and rest before the flight home to Ft. Lauderdale). I really
Progress Summary of my journey
(08/18/2019) Last week, I saw my Radiation Oncologist. I signed all the forms to enter a study targeting oligometastatic prostate cancer patients - if early radiation treatment of the metastatic lesions improves survival times. Of interest is that the prostate shows regression after about 2 ½ months
(08/18/2019) Last week, I saw my Radiation Oncologist. I signed all the forms to enter a study targeting oligometastatic prostate cancer patients - if early radiation treatment of the metastatic lesions improves survival times. Of interest is that the prostate shows regression after about 2 ½ months
Efficacy of Radium-223 in Bone-Metastatic Castration-Resistant Prostate Cancer With and Without Homologous Repair Gene Defects
This is another small-sample piece on radionuclides and Homologous Repair Defects. Dr. Sartor also made an additional comment on this piece right here. I'm hoping to see genetic profiling becoming a standard procedure for all cancer patients. "TAKE-HOME MESSAGE Somatic tumor and germline DNA testing
This is another small-sample piece on radionuclides and Homologous Repair Defects. Dr. Sartor also made an additional comment on this piece right here. I'm hoping to see genetic profiling becoming a standard procedure for all cancer patients. "TAKE-HOME MESSAGE Somatic tumor and germline DNA testing
Efficacy of Radium-223 in Bone-Metastatic Castration-Resistant Prostate Cancer With and Without Homologous Repair Gene Defects
TAKE-HOME MESSAGE •Somatic tumor and germline DNA testing are becoming more meaningful in the management of patients with advanced prostate cancer. This study evaluated the potential impact of germline or somatic homologous recombination deficiency (HRD) mutations on radium-223 efficacy in metastatic
TAKE-HOME MESSAGE •Somatic tumor and germline DNA testing are becoming more meaningful in the management of patients with advanced prostate cancer. This study evaluated the potential impact of germline or somatic homologous recombination deficiency (HRD) mutations on radium-223 efficacy in metastatic
If ADT can "hide" mets on PSMA PET CT, lesions can still be seen on MRI, no?
That's my question. How to know if mets are growing or maybe have disappeared on ADT (if this is really possible) or if on ADT + radiation ? PSMA CET CT best scan could not give a good result on ADT, what about MRI? Other options (would (bone) alkaline phosphatase still be a marker?)?
That's my question. How to know if mets are growing or maybe have disappeared on ADT (if this is really possible) or if on ADT + radiation ? PSMA CET CT best scan could not give a good result on ADT, what about MRI? Other options (would (bone) alkaline phosphatase still be a marker?)?
Efficacy of Radium-223 in Bone-Metastatic Castration-Resistant Prostate Cancer With and Without Homologous Repair Gene Defects
TAKE-HOME MESSAGE Somatic tumor and germline DNA testing are becoming more meaningful in the management of patients with advanced prostate cancer. This study evaluated the potential impact of germline or somatic homologous recombination deficiency (HRD) mutations on radium-223 efficacy in metastatic
TAKE-HOME MESSAGE Somatic tumor and germline DNA testing are becoming more meaningful in the management of patients with advanced prostate cancer. This study evaluated the potential impact of germline or somatic homologous recombination deficiency (HRD) mutations on radium-223 efficacy in metastatic
Whats in a Dx?
There no mention of a lobe shift for neutrophils or LDH, B12 levels, PCR or Elevated
Alkaline
Phosphatase
. I have a positive Jak2
test
. My father also had similar symptoms at about the same age. I'm thinking my blood picture reflects more a Dx of Chronic Neutrophilic Leukemia.
There no mention of a lobe shift for neutrophils or LDH, B12 levels, PCR or Elevated
Alkaline
Phosphatase
. I have a positive Jak2
test
. My father also had similar symptoms at about the same age. I'm thinking my blood picture reflects more a Dx of Chronic Neutrophilic Leukemia.
Liver Tests
I have just had a blood
test
showing that I have raised Liver levels
Alkaline
Phosphatase
raised to 151 and GT to 541. I do not have doctor appointment for two weeks and have no idea what this means. Does anyone know what are normal levels and if any heart meds could course this ?
I have just had a blood
test
showing that I have raised Liver levels
Alkaline
Phosphatase
raised to 151 and GT to 541. I do not have doctor appointment for two weeks and have no idea what this means. Does anyone know what are normal levels and if any heart meds could course this ?
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