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Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?

Doxazosin, an alpha1-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH) and hypertension. Alpha-adrenoceptor antagonists also inhibit growth and induce apoptosis in malignant prostatic cells. The apoptotic activity is independent of their capacity to antagonize
Doxazosin, an alpha1-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH) and hypertension. Alpha-adrenoceptor antagonists also inhibit growth and induce apoptosis in malignant prostatic cells. The apoptotic activity is independent of their capacity to antagonize
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Hidden
in Advanced Prostate Cancer

Zinc dipicolinate can be used to smuggle zinc into prostate cancer cells

Abstract Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion, it loses its capacity to import zinc while undergoing malignant transformation. This exclusion of zinc may be necessary for the viability of prostate cancer, as measures which increase the intracellular
Abstract Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion, it loses its capacity to import zinc while undergoing malignant transformation. This exclusion of zinc may be necessary for the viability of prostate cancer, as measures which increase the intracellular
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Hidden
in Advanced Prostate Cancer

Balinitis

I myself am a doctor. Had similar issue as the comments. Had sti screen: negative Was advised to use antifungal plus antibiotic and hydrocortisone. Made skin very sensitive and uncomfortable. Stopped everything and used sudocrem for 2 weeks. Symptoms all resolved. Skin is mildly wrinkly but improved
I myself am a doctor. Had similar issue as the comments. Had sti screen: negative Was advised to use antifungal plus antibiotic and hydrocortisone. Made skin very sensitive and uncomfortable. Stopped everything and used sudocrem for 2 weeks. Symptoms all resolved. Skin is mildly wrinkly but improved
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Zeus366
in Men's Health Forum (Penis Health)
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I Can't Keep Up This Stack :(

You all are so much stronger than I am. Or maybe you are living your lives instead of obsessing over things that can't be changed. I know I got carried away with supplements, but no more. It is just too much. (for those unfamiliar, I have not been diagnosed with PD. I have REM Sleep Behavior Disorder
You all are so much stronger than I am. Or maybe you are living your lives instead of obsessing over things that can't be changed. I know I got carried away with supplements, but no more. It is just too much. (for those unfamiliar, I have not been diagnosed with PD. I have REM Sleep Behavior Disorder
Bolt_Upright profile image
Bolt_Upright
in Cure Parkinson's

Table tennis consultant and Gp

My husband has Aspergillosis , COPD , leaky heart valve , ongoing conditions for 17 years . Starting last November he developed a really distressing cough , not Covid and not an infection , not the Aspergillosis cough , he cannot take anti fungal drugs and is life limiting so was referred to a hospice
My husband has Aspergillosis , COPD , leaky heart valve , ongoing conditions for 17 years . Starting last November he developed a really distressing cough , not Covid and not an infection , not the Aspergillosis cough , he cannot take anti fungal drugs and is life limiting so was referred to a hospice
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Daisy55
in Lung Conditions Community Forum

I Made Coconut Milk Yogurt Yesterday

So I use the Yakult probiotic drink that has so many great qualities (lactobacillus casei Shirota, which is both the probiotic used in the PD study that showed it helped with bowel movements and is also anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal. It has been shown to reduce the EBV
So I use the Yakult probiotic drink that has so many great qualities (lactobacillus casei Shirota, which is both the probiotic used in the PD study that showed it helped with bowel movements and is also anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal. It has been shown to reduce the EBV
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Bolt_Upright
in Cure Parkinson's

Zeolite ; helpful & not helpful ? Good for cleansing our system , removing metals, or no?

If you have experience with using zeolite can you please share your motivation to and your experience? I have read about the intention of it being anti fungal and “cleansing” but then I’ve read that it does not chelate metals as it claims and can reduce the minerals we need like magnesium. Knowledge
If you have experience with using zeolite can you please share your motivation to and your experience? I have read about the intention of it being anti fungal and “cleansing” but then I’ve read that it does not chelate metals as it claims and can reduce the minerals we need like magnesium. Knowledge
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NeuroResearcher
in Cure Parkinson's

Antifungal agent farnesol effective in Parkinson’s?

If an anti fungal agent is effective in stopping Parkinson’s then ask, is Parkinson’s induced or made worse by fungus? Is there fungus among us?
If an anti fungal agent is effective in stopping Parkinson’s then ask, is Parkinson’s induced or made worse by fungus? Is there fungus among us?
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NeuroResearcher
in Cure Parkinson's

My Latest Stack: Anybody want to deep dive on protocols?

So this is my latest stack. I think I have a good list now. Now it is time to fine tune it. Get the dosages and timing right. Will any of it help? I hope so. I have not been diagnosed with PD. I have been diagnosed with REM Sleep Behavior Disorder (with other troubling symptoms). I still have a sore
So this is my latest stack. I think I have a good list now. Now it is time to fine tune it. Get the dosages and timing right. Will any of it help? I hope so. I have not been diagnosed with PD. I have been diagnosed with REM Sleep Behavior Disorder (with other troubling symptoms). I still have a sore
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Bolt_Upright
in Cure Parkinson's

Probiotics for Parkinson's disease: Current evidence and future directions 2020

So... I'm taking lactobacillus casei Shirota, which is both the probiotic used in the PD study that showed it helped with bowel movements and is also anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal. It has been shown to reduce the EBV titers in your system too. If you think PD is autoimmune
So... I'm taking lactobacillus casei Shirota, which is both the probiotic used in the PD study that showed it helped with bowel movements and is also anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal. It has been shown to reduce the EBV titers in your system too. If you think PD is autoimmune
Bolt_Upright profile image
Bolt_Upright
in Cure Parkinson's

Taking too long to recover after circumcision and what to put on scars to help them

Hello, people, please help. I had a circumcision in mid August of 2021 (4 months and 2 weeks ago) due to phimosis. Only in the last week of September (5 weeks after operation) I was able to walk outside somewhat fine. It was hurting a lot in the beginning but by last week of October I was pretty good
Hello, people, please help. I had a circumcision in mid August of 2021 (4 months and 2 weeks ago) due to phimosis. Only in the last week of September (5 weeks after operation) I was able to walk outside somewhat fine. It was hurting a lot in the beginning but by last week of October I was pretty good
ihapidp profile image
ihapidp
in Men's Health Forum (Penis Health)

Mum 75 yo in ICU - covid phumonia and infection - stable but doctors give no hope

Our mum was doing well last week she was heading in the right direction and the doctors were even talking about doing a tracheostomy within a few days then she took a turn on Thursday and we were called in but while we were there she stabilised. She has been stable since, no better no worse but spoke
Our mum was doing well last week she was heading in the right direction and the doctors were even talking about doing a tracheostomy within a few days then she took a turn on Thursday and we were called in but while we were there she stabilised. She has been stable since, no better no worse but spoke
djsioux profile image
djsioux
in ICUsteps

Male Genital Redness

Hi, am looking for some advice guidance regarding my condition. Just over a year ago my genitals looked like they had been badly sunburned. I tried moisturisers and the skin peeled and cracked and there was a terrible odour from the area. I spoke to my GP (with Covid they were not seeing patients) who
Hi, am looking for some advice guidance regarding my condition. Just over a year ago my genitals looked like they had been badly sunburned. I tried moisturisers and the skin peeled and cracked and there was a terrible odour from the area. I spoke to my GP (with Covid they were not seeing patients) who
AndyMac1965 profile image
AndyMac1965
in MY SKIN

And on we go.....

So yesterday I saw the new Rheumy and very nice she was too. All scores zero so remission continues but because of infections I have to change and so its now onto Abatarcept. I did think this might have happened as I've taken 9 lots of antibiotics in 18 months plus two lots of anti fungal stuff. I'm
So yesterday I saw the new Rheumy and very nice she was too. All scores zero so remission continues but because of infections I have to change and so its now onto Abatarcept. I did think this might have happened as I've taken 9 lots of antibiotics in 18 months plus two lots of anti fungal stuff. I'm
medway-lady profile image
medway-lady
in NRAS

Tablets not working

Has anybody else had a problem with steroids and anti fungal tablets not working for ABPA so had to come if them ?
Has anybody else had a problem with steroids and anti fungal tablets not working for ABPA so had to come if them ?
Midge4547 profile image
Midge4547
in Aspergillosis and Rare Fungal Infection Support

Doctors don’t know what’s wrong with my penis please help!!

I am 20-years-old and have been freaking out for the past 10 weeks because my penis is constantly red and sore. The glans is red under the foreskin, the urethral opening is sore and red, and the frenulum feels very tight and stings where it meets the glans. Every time I masturbate the frenulum stings
I am 20-years-old and have been freaking out for the past 10 weeks because my penis is constantly red and sore. The glans is red under the foreskin, the urethral opening is sore and red, and the frenulum feels very tight and stings where it meets the glans. Every time I masturbate the frenulum stings
Qhasts123 profile image
Qhasts123
in Men's Health Forum (Penis Health)

Terbinafine

New German study below [1]. "... squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival ..." "Inhibition of SQLE with the FDA approved antifungal drug terbinafine ... efficiently blocked orthotopic
New German study below [1]. "... squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival ..." "Inhibition of SQLE with the FDA approved antifungal drug terbinafine ... efficiently blocked orthotopic
pjoshea13 profile image
pjoshea13
in Advanced Prostate Cancer

Wait & Watch - What does it entail?

I’m relatively new to the CLL community. My diagnosis was incidental while following up with blood tests post COVID infection. I’m currently on W&W with a Rai score of 0. This community has been a great support and I’ve learnt a lot here. It has given me hope & reassurance. I’m still confused about
I’m relatively new to the CLL community. My diagnosis was incidental while following up with blood tests post COVID infection. I’m currently on W&W with a Rai score of 0. This community has been a great support and I’ve learnt a lot here. It has given me hope & reassurance. I’m still confused about
nuji profile image
nuji
in CLL Support

Dryness, Cracks and Peeling on penis skin

I was using antifungal medicines like clotrimazol creme e.t.c.
I was using antifungal medicines like clotrimazol creme e.t.c.
koroookkl profile image
koroookkl
in Men's Health Forum (Penis Health)

Can thrush discharge cause kidney infections?

Please someone help me or give me advice cause with Covid the gp and doctors aren’t taking this seriously.. Im starting to realise I may have a bad thrush or discharge problem. I have been sitting in pain on the toilet for three days now with a kidney infection but I have noticed that a lot of thrush
Please someone help me or give me advice cause with Covid the gp and doctors aren’t taking this seriously.. Im starting to realise I may have a bad thrush or discharge problem. I have been sitting in pain on the toilet for three days now with a kidney infection but I have noticed that a lot of thrush
Jepo profile image
Jepo
in BASHH
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