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Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?
Doxazosin
, an alpha1-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH) and hypertension. Alpha-adrenoceptor antagonists also inhibit growth and induce apoptosis in malignant prostatic cells. The apoptotic activity is independent of their capacity to antagonize
Doxazosin
, an alpha1-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH) and hypertension. Alpha-adrenoceptor antagonists also inhibit growth and induce apoptosis in malignant prostatic cells. The apoptotic activity is independent of their capacity to antagonize
Hidden
in
Advanced Prostate Cancer
Zinc dipicolinate can be used to smuggle zinc into prostate cancer cells
Abstract Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion, it loses its capacity to import zinc while undergoing malignant transformation. This exclusion of zinc may be necessary for the viability of prostate cancer, as measures which increase the intracellular
Abstract Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion, it loses its capacity to import zinc while undergoing malignant transformation. This exclusion of zinc may be necessary for the viability of prostate cancer, as measures which increase the intracellular
Hidden
in
Advanced Prostate Cancer
Balinitis
I myself am a doctor. Had similar issue as the comments. Had sti screen: negative Was advised to use antifungal plus antibiotic and hydrocortisone. Made skin very sensitive and uncomfortable. Stopped everything and used sudocrem for 2 weeks. Symptoms all resolved. Skin is mildly wrinkly but improved
I myself am a doctor. Had similar issue as the comments. Had sti screen: negative Was advised to use antifungal plus antibiotic and hydrocortisone. Made skin very sensitive and uncomfortable. Stopped everything and used sudocrem for 2 weeks. Symptoms all resolved. Skin is mildly wrinkly but improved
Zeus366
in
Men's Health Forum (Penis Health)
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I Can't Keep Up This Stack :(
You all are so much stronger than I am. Or maybe you are living your lives instead of obsessing over things that can't be changed. I know I got carried away with supplements, but no more. It is just too much. (for those unfamiliar, I have not been diagnosed with PD. I have REM Sleep Behavior Disorder
You all are so much stronger than I am. Or maybe you are living your lives instead of obsessing over things that can't be changed. I know I got carried away with supplements, but no more. It is just too much. (for those unfamiliar, I have not been diagnosed with PD. I have REM Sleep Behavior Disorder
Bolt_Upright
in
Cure Parkinson's
Table tennis consultant and Gp
My husband has Aspergillosis , COPD , leaky heart valve , ongoing conditions for 17 years . Starting last November he developed a really distressing cough , not Covid and not an infection , not the Aspergillosis cough , he cannot take anti fungal drugs and is life limiting so was referred to a hospice
My husband has Aspergillosis , COPD , leaky heart valve , ongoing conditions for 17 years . Starting last November he developed a really distressing cough , not Covid and not an infection , not the Aspergillosis cough , he cannot take anti fungal drugs and is life limiting so was referred to a hospice
Daisy55
in
Lung Conditions Community Forum
I Made Coconut Milk Yogurt Yesterday
So I use the Yakult probiotic drink that has so many great qualities (lactobacillus casei Shirota, which is both the probiotic used in the PD study that showed it helped with bowel movements and is also anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal. It has been shown to reduce the EBV
So I use the Yakult probiotic drink that has so many great qualities (lactobacillus casei Shirota, which is both the probiotic used in the PD study that showed it helped with bowel movements and is also anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal. It has been shown to reduce the EBV
Bolt_Upright
in
Cure Parkinson's
Zeolite ; helpful & not helpful ? Good for cleansing our system , removing metals, or no?
If you have experience with using zeolite can you please share your motivation to and your experience? I have read about the intention of it being anti fungal and “cleansing” but then I’ve read that it does not chelate metals as it claims and can reduce the minerals we need like magnesium. Knowledge
If you have experience with using zeolite can you please share your motivation to and your experience? I have read about the intention of it being anti fungal and “cleansing” but then I’ve read that it does not chelate metals as it claims and can reduce the minerals we need like magnesium. Knowledge
NeuroResearcher
in
Cure Parkinson's
Antifungal agent farnesol effective in Parkinson’s?
If an anti fungal agent is effective in stopping Parkinson’s then ask, is Parkinson’s induced or made worse by fungus? Is there fungus among us?
If an anti fungal agent is effective in stopping Parkinson’s then ask, is Parkinson’s induced or made worse by fungus? Is there fungus among us?
NeuroResearcher
in
Cure Parkinson's
My Latest Stack: Anybody want to deep dive on protocols?
So this is my latest stack. I think I have a good list now. Now it is time to fine tune it. Get the dosages and timing right. Will any of it help? I hope so. I have not been diagnosed with PD. I have been diagnosed with REM Sleep Behavior Disorder (with other troubling symptoms). I still have a sore
So this is my latest stack. I think I have a good list now. Now it is time to fine tune it. Get the dosages and timing right. Will any of it help? I hope so. I have not been diagnosed with PD. I have been diagnosed with REM Sleep Behavior Disorder (with other troubling symptoms). I still have a sore
Bolt_Upright
in
Cure Parkinson's
Probiotics for Parkinson's disease: Current evidence and future directions 2020
So... I'm taking lactobacillus casei Shirota, which is both the probiotic used in the PD study that showed it helped with bowel movements and is also anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal. It has been shown to reduce the EBV titers in your system too. If you think PD is autoimmune
So... I'm taking lactobacillus casei Shirota, which is both the probiotic used in the PD study that showed it helped with bowel movements and is also anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal. It has been shown to reduce the EBV titers in your system too. If you think PD is autoimmune
Bolt_Upright
in
Cure Parkinson's
Taking too long to recover after circumcision and what to put on scars to help them
Hello, people, please help. I had a circumcision in mid August of 2021 (4 months and 2 weeks ago) due to phimosis. Only in the last week of September (5 weeks after operation) I was able to walk outside somewhat fine. It was hurting a lot in the beginning but by last week of October I was pretty good
Hello, people, please help. I had a circumcision in mid August of 2021 (4 months and 2 weeks ago) due to phimosis. Only in the last week of September (5 weeks after operation) I was able to walk outside somewhat fine. It was hurting a lot in the beginning but by last week of October I was pretty good
ihapidp
in
Men's Health Forum (Penis Health)
Mum 75 yo in ICU - covid phumonia and infection - stable but doctors give no hope
Our mum was doing well last week she was heading in the right direction and the doctors were even talking about doing a tracheostomy within a few days then she took a turn on Thursday and we were called in but while we were there she stabilised. She has been stable since, no better no worse but spoke
Our mum was doing well last week she was heading in the right direction and the doctors were even talking about doing a tracheostomy within a few days then she took a turn on Thursday and we were called in but while we were there she stabilised. She has been stable since, no better no worse but spoke
djsioux
in
ICUsteps
Male Genital Redness
Hi, am looking for some advice guidance regarding my condition. Just over a year ago my genitals looked like they had been badly sunburned. I tried moisturisers and the skin peeled and cracked and there was a terrible odour from the area. I spoke to my GP (with Covid they were not seeing patients) who
Hi, am looking for some advice guidance regarding my condition. Just over a year ago my genitals looked like they had been badly sunburned. I tried moisturisers and the skin peeled and cracked and there was a terrible odour from the area. I spoke to my GP (with Covid they were not seeing patients) who
AndyMac1965
in
MY SKIN
And on we go.....
So yesterday I saw the new Rheumy and very nice she was too. All scores zero so remission continues but because of infections I have to change and so its now onto Abatarcept. I did think this might have happened as I've taken 9 lots of antibiotics in 18 months plus two lots of anti fungal stuff. I'm
So yesterday I saw the new Rheumy and very nice she was too. All scores zero so remission continues but because of infections I have to change and so its now onto Abatarcept. I did think this might have happened as I've taken 9 lots of antibiotics in 18 months plus two lots of anti fungal stuff. I'm
medway-lady
in
NRAS
Tablets not working
Has anybody else had a problem with steroids and anti fungal tablets not working for ABPA so had to come if them ?
Has anybody else had a problem with steroids and anti fungal tablets not working for ABPA so had to come if them ?
Midge4547
in
Aspergillosis and Rare Fungal Infection Support
Doctors don’t know what’s wrong with my penis please help!!
I am 20-years-old and have been freaking out for the past 10 weeks because my penis is constantly red and sore. The glans is red under the foreskin, the urethral opening is sore and red, and the frenulum feels very tight and stings where it meets the glans. Every time I masturbate the frenulum stings
I am 20-years-old and have been freaking out for the past 10 weeks because my penis is constantly red and sore. The glans is red under the foreskin, the urethral opening is sore and red, and the frenulum feels very tight and stings where it meets the glans. Every time I masturbate the frenulum stings
Qhasts123
in
Men's Health Forum (Penis Health)
Terbinafine
New German study below [1]. "... squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival ..." "Inhibition of SQLE with the FDA approved antifungal drug terbinafine ... efficiently blocked orthotopic
New German study below [1]. "... squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival ..." "Inhibition of SQLE with the FDA approved antifungal drug terbinafine ... efficiently blocked orthotopic
pjoshea13
in
Advanced Prostate Cancer
Wait & Watch - What does it entail?
I’m relatively new to the CLL community. My diagnosis was incidental while following up with blood tests post COVID infection. I’m currently on W&W with a Rai score of 0. This community has been a great support and I’ve learnt a lot here. It has given me hope & reassurance. I’m still confused about
I’m relatively new to the CLL community. My diagnosis was incidental while following up with blood tests post COVID infection. I’m currently on W&W with a Rai score of 0. This community has been a great support and I’ve learnt a lot here. It has given me hope & reassurance. I’m still confused about
nuji
in
CLL Support
Dryness, Cracks and Peeling on penis skin
I was using
antifungal
medicines
like clotrimazol creme e.t.c.
I was using
antifungal
medicines
like clotrimazol creme e.t.c.
koroookkl
in
Men's Health Forum (Penis Health)
Can thrush discharge cause kidney infections?
Please someone help me or give me advice cause with Covid the gp and doctors aren’t taking this seriously.. Im starting to realise I may have a bad thrush or discharge problem. I have been sitting in pain on the toilet for three days now with a kidney infection but I have noticed that a lot of thrush
Please someone help me or give me advice cause with Covid the gp and doctors aren’t taking this seriously.. Im starting to realise I may have a bad thrush or discharge problem. I have been sitting in pain on the toilet for three days now with a kidney infection but I have noticed that a lot of thrush
Jepo
in
BASHH
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