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Enzalutamide plus leuprolide reduces risk of metastasis in nonmetastatic HSPC men-from Urology Times, 29 Apr 2023
Findings from the phase 3 EMBARK trial showed that enzalutamide (Xtandi) plus leuprolide reduced the risk of metastasis or death by nearly 60% vs placebo plus leuprolide in patients with nonmetastatic hormone-sensitive prostate cancer (nmHSPC) with high-risk biochemical recurrence (BCR).1,2 "The
Findings from the phase 3 EMBARK trial showed that enzalutamide (Xtandi) plus leuprolide reduced the risk of metastasis or death by nearly 60% vs placebo plus leuprolide in patients with nonmetastatic hormone-sensitive prostate cancer (nmHSPC) with high-risk biochemical recurrence (BCR).1,2 "The
Balsam01
in
Advanced Prostate Cancer
1 year ago
EMBARK trial
Watching the results of the EMBARK trial with great interest as they had a ‘Lutamide monotheraoy’ arm that has performed very well and now questions are being asked about needing ADT for high risk of BCR in the hormone sensitive. Not matching my position of course ( there is no population that does)
Watching the results of the EMBARK trial with great interest as they had a ‘Lutamide monotheraoy’ arm that has performed very well and now questions are being asked about needing ADT for high risk of BCR in the hormone sensitive. Not matching my position of course ( there is no population that does)
Brysonal
in
Fight Prostate Cancer
1 year ago
Orchidectomy?
I have no plans to have an orchidectomy but I’m curious why some men do get them. I get that it allows one to avoid needing the periodic injections. But as I understand it one still has to take something to deal with the testosterone that is still produced by the adrenal glands even after the orchidectomy
I have no plans to have an orchidectomy but I’m curious why some men do get them. I get that it allows one to avoid needing the periodic injections. But as I understand it one still has to take something to deal with the testosterone that is still produced by the adrenal glands even after the orchidectomy
fireandice123
in
Advanced Prostate Cancer
1 year ago
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ART Effect Of Adjuvant And Salvage Radiotherapy After Radical Prostatectomy On Urinary Continence
Well, I am 'continent' according to the criteria in this study (a bit old, but not ancient)...of course continence here is defined as "[i]no pads or one safety pad.[/i]" OK. Now, I went into sRT with a safety pad and was warned by my RO that this had a chance of being 'locked in.' I proceeded anyway
Well, I am 'continent' according to the criteria in this study (a bit old, but not ancient)...of course continence here is defined as "[i]no pads or one safety pad.[/i]" OK. Now, I went into sRT with a safety pad and was warned by my RO that this had a chance of being 'locked in.' I proceeded anyway
RMontana
in
Active Surveillance - Prostate Cancer
1 year ago
Dreams, dreams, dreams
I have been receiving Lupron shots every three months and taking Xtandi daily for a little more than a year. This follows a RALP and 36 days of radiation, all parts of my doctors’ kitchen sink strategy. No doubt there is a lot going on in my body. One of the most persistent side effects, however,
I have been receiving Lupron shots every three months and taking Xtandi daily for a little more than a year. This follows a RALP and 36 days of radiation, all parts of my doctors’ kitchen sink strategy. No doubt there is a lot going on in my body. One of the most persistent side effects, however,
aloha_spaceman
in
Advanced Prostate Cancer
1 year ago
Casodex
Is anyone doing only Casodex for their ADT together with their salvage rad? Are there any disadvantages for a six month course? Seems like it would make T recovery less of a problem.
Is anyone doing only Casodex for their ADT together with their salvage rad? Are there any disadvantages for a six month course? Seems like it would make T recovery less of a problem.
ElRanchoDePoisonIvy
in
Advanced Prostate Cancer
1 year ago
Parkinsons & Prostate cancer
My husband is the PWP and has recently been diagnosed with Prostate cancer. He is having hormone therapy now in the form of Prostap injection every 3 months prior to Radiotherapy.He is now having more difficulty with walking , particularly turning, since the hormone treatment started and wondering if
My husband is the PWP and has recently been diagnosed with Prostate cancer. He is having hormone therapy now in the form of Prostap injection every 3 months prior to Radiotherapy.He is now having more difficulty with walking , particularly turning, since the hormone treatment started and wondering if
Jalia
in
Cure Parkinson's
1 year ago
leg weakness with prolapse
Hi. I have been suffering from incontinence back pain, weak legs, very painful to have sex for years at least 12 if not more. I was always very fit. I have two sons who I played squash with swam 100 lengths of our local pool every morning before going to work in my full time job where I lifted heavy
Hi. I have been suffering from incontinence back pain, weak legs, very painful to have sex for years at least 12 if not more. I was always very fit. I have two sons who I played squash with swam 100 lengths of our local pool every morning before going to work in my full time job where I lifted heavy
01269JJ
in
Pelvic Pain Support Network
1 year ago
Any suggestions for supplements to augment Docetaxel/ADT?
Halfway through chemo with Docetaxel. PSA at 0.02 for last two measurements. Anyone aware of any supplements that may help? I am also on Lupron and darolutamide. Treating Pulmonary mets.
Halfway through chemo with Docetaxel. PSA at 0.02 for last two measurements. Anyone aware of any supplements that may help? I am also on Lupron and darolutamide. Treating Pulmonary mets.
RoseDoc
in
Advanced Prostate Cancer
1 year ago
Not the news I was hoping for
Just had my second PSMA/PET scan - the first one was in October and was clear - my PSA had risen to 0.2. My PSA has been jumping around but has trended up the last two months to 2.5. So I went to Mayo for my scan today. Impression 1. Worsening of T9 hypermetabolic lesion (miPSMA score 3). 2. New
Just had my second PSMA/PET scan - the first one was in October and was clear - my PSA had risen to 0.2. My PSA has been jumping around but has trended up the last two months to 2.5. So I went to Mayo for my scan today. Impression 1. Worsening of T9 hypermetabolic lesion (miPSMA score 3). 2. New
PabloK
in
Advanced Prostate Cancer
1 year ago
Intermittent ADT
It's a difficult decision. Here are things to consider: https://www.prostatecancer.news/2023/04/intermittent-adt.html
It's a difficult decision. Here are things to consider: https://www.prostatecancer.news/2023/04/intermittent-adt.html
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
Travel insurance and prostate cancer
I have had HIFU for prostate cancer that was only partially successful. Subsequently my PSA started to rise again so I was treated 5 years ago with docetaxel followed by decapeptyl hormone therapy starting 4 years ago. I want to go on holiday. Can anyone recommend a travel insurance company that will
I have had HIFU for prostate cancer that was only partially successful. Subsequently my PSA started to rise again so I was treated 5 years ago with docetaxel followed by decapeptyl hormone therapy starting 4 years ago. I want to go on holiday. Can anyone recommend a travel insurance company that will
uclhman
in
Advanced Prostate Cancer
1 year ago
Best use of Psa to guide intermittent hormone therapy
presently on relugolix + Darolutamide for local reccurrence and will go off these drugs if Psa is less than .65 three months ago tested and go back on when Psa reaches 3-5.. Seems it will be about 6months and hopefully 6 months off, Tentative protocol so far. Input from all and for all welcomed. Thanks
presently on relugolix + Darolutamide for local reccurrence and will go off these drugs if Psa is less than .65 three months ago tested and go back on when Psa reaches 3-5.. Seems it will be about 6months and hopefully 6 months off, Tentative protocol so far. Input from all and for all welcomed. Thanks
rococo
in
Advanced Prostate Cancer
1 year ago
Xtandi
Pet scan Aug 8, 2022 showed 5 lymph nodes with CA. Urologist started me on Xtandi and referred me to an Oncologist who started Degarelix injections. Oct 25, 2022 stopped taking Xtandi due to intolerable side effects; started Bicalutamide. PSA was 0.47 in Oct with gradual increase to 4.8 in Apr. Oncologist
Pet scan Aug 8, 2022 showed 5 lymph nodes with CA. Urologist started me on Xtandi and referred me to an Oncologist who started Degarelix injections. Oct 25, 2022 stopped taking Xtandi due to intolerable side effects; started Bicalutamide. PSA was 0.47 in Oct with gradual increase to 4.8 in Apr. Oncologist
racoonwar
in
Advanced Prostate Cancer
1 year ago
Effect of low endogenous testosterone
PSA now at 7.9. Biopsy showed 1 sample was Gleason 8. Starting ADT and radiation soon. Have had low testosterone (<150 ng/ml) most of my life. Non-existent libido, depression and tired most of the time. Recent studies have shown that aggressive prostate cancer more common in people with low testosterone
PSA now at 7.9. Biopsy showed 1 sample was Gleason 8. Starting ADT and radiation soon. Have had low testosterone (<150 ng/ml) most of my life. Non-existent libido, depression and tired most of the time. Recent studies have shown that aggressive prostate cancer more common in people with low testosterone
Doodlebun
in
Advanced Prostate Cancer
1 year ago
Vacation time again
I had the follow up appt with my MO. My PSA is down a notch to 0.2. We decided to follow the original plan of intermittent ADT and I’m starting another ADT vacation. This round of ADT had started with minimal SE’s but in the last month or so it’s gotten worse. My energy level has noticeably decreased
I had the follow up appt with my MO. My PSA is down a notch to 0.2. We decided to follow the original plan of intermittent ADT and I’m starting another ADT vacation. This round of ADT had started with minimal SE’s but in the last month or so it’s gotten worse. My energy level has noticeably decreased
fireandice123
in
Advanced Prostate Cancer
1 year ago
advanced prostate cancer
I have been following this group for about a year! Thank you for all the information. I don’t have my husband pathology report in front of me! I do know that we have a Gleason 8 and 11/12 cores positive for cancer. Psa was 6.7 Prostate cancer escaped his capsule to some lymph nodes I believe 2 has
I have been following this group for about a year! Thank you for all the information. I don’t have my husband pathology report in front of me! I do know that we have a Gleason 8 and 11/12 cores positive for cancer. Psa was 6.7 Prostate cancer escaped his capsule to some lymph nodes I believe 2 has
Murphpup
in
Advanced Prostate Cancer
1 year ago
what to expect
I was diagnosed in September with metastatic prostate cancer related to the braca2 Gene. I went on the Lupron and then.Abiraterone in December. I’ve now had five out of six docetaxel chemo sessions. my energy has been shot to hell. There are days that it’s all I can do but get out of bed. I can
I was diagnosed in September with metastatic prostate cancer related to the braca2 Gene. I went on the Lupron and then.Abiraterone in December. I’ve now had five out of six docetaxel chemo sessions. my energy has been shot to hell. There are days that it’s all I can do but get out of bed. I can
DoubleBlind
in
Advanced Prostate Cancer
1 year ago
ART ASCO GU 2023: Testosterone Recovery Following Androgen Suppression and Prostate Radiotherapy (TRANSPORT)
There are many studies that show TET recovery for men treated with RT and ADT. Most show delay is correlated to the time spent under ADT treatment. I have seen some posts that purport 5 year [u]average timeframes[/u]; this appeared excessive. This study provides better data and timeframes that are
There are many studies that show TET recovery for men treated with RT and ADT. Most show delay is correlated to the time spent under ADT treatment. I have seen some posts that purport 5 year [u]average timeframes[/u]; this appeared excessive. This study provides better data and timeframes that are
RMontana
in
Active Surveillance - Prostate Cancer
1 year ago
thoughts on virtual second opinions
Hi all,My dad was diagnosed with stage 4 metastatic prostate cancer about 5 weeks ago. He is 65 years old. His current MO has him on a zoladex injection and next ADT has yet to be added. I was looking into getting a second opinion at MD Anderson, Mayo and Sloan Kettering. I noticed that all offered
Hi all,My dad was diagnosed with stage 4 metastatic prostate cancer about 5 weeks ago. He is 65 years old. His current MO has him on a zoladex injection and next ADT has yet to be added. I was looking into getting a second opinion at MD Anderson, Mayo and Sloan Kettering. I noticed that all offered
Jdhanoa
in
Advanced Prostate Cancer
1 year ago
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