There are many studies that show TET recovery for men treated with RT and ADT. Most show delay is correlated to the time spent under ADT treatment. I have seen some posts that purport 5 year average timeframes; this appeared excessive. This study provides better data and timeframes that are better adapted to the different types of exposure to ADT. Of interest are the wide ranges shown for CI (confidence intervals) for each recovery range. This means depending on your unique physiology, health and underlying medical conditions recovery could be quick, late and for 30% of us never. Also, that the ‘p’ factor (probability that the outcome is wrong) of 0.3 provided no statistical correlation for the findings linking age, ADT exposure and FTR recovery…good news for us old timers…
I don’t want to think about my TET never returning so will wait to see what happens as my median time range materializes. Also, will try to do the best I can to take care of what’s left of this body so as to give it the best chance possible. Odd that should TET fully recover our doctors will be well pleased and consider it normal. If it does not and we want TRT (replacement therapy) then TET is an accelerant to PCa and is promptly denied…which is it? Regardless, see if this study helps you zero in on when you could look at TET recovery and provide some ‘expectation management’ which we all need fighting our unwanted guest. Rick
ASCO GU 2023: In this study they identified 1439 men with non-castrate testosterone at baseline (> 1. 7nmol/L – 50 ng/dL) who met the inclusion criteria for analysis. Among these 1439 men, 220, 765 and 454 men had 3-, 6-, and 18-months of ADT.
As of the last follow-up date of the study, 959 (67%) men had FTR (full testosterone recovery >10.5nmol/L – 303 ng/dL)). For men who had 3-, 6-, and 18-months of ADT, the median time range to NHTR (non-hypogonadal TR (NHTR) >8.0nmol/L – 230 ng/dL) were 5.5 (1.6-76.3), 12.2 (0.8-53.6), and 30.1 (2.8-90.4) months respectively, while the median time range to FTR were 6.2 (1.8-75. 7), 15.2 (0.8-86.0), and 36.0 (18.1-85.5) months respectively.
Among a subset of 1160 men who had normal testosterone at baseline (>10.5nmol/L), 851 (69%) men had FTR, with a median time (range) to FTR of 5.5 (1.8-75.7), 12.7 (1.8-86.0), and 30.8 (18.1-84.1) months for men who had 3-, 6- and 18-months ADT, respectively.
The authors found no evidence of interaction between the effect of ADT duration on time to FTR and age (interaction P=0.3 for entire cohort). FTR brackets ranges show the 95% confidence interval for which the median is identified.
PS there are 28.85 ng/dL in 1 nmol/ml...
