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COSMIC-021 trial
Cabozantinib plus atezolizumab showed promising antitumour activity in patients with metastatic castration-resistant prostate cancer after novel hormonal therapy with an acceptable safety profile, supporting further evaluation of this combination. https://www.thelancet.com/journals/lanonc/article/PIIS1470
Cabozantinib plus atezolizumab showed promising antitumour activity in patients with metastatic castration-resistant prostate cancer after novel hormonal therapy with an acceptable safety profile, supporting further evaluation of this combination. https://www.thelancet.com/journals/lanonc/article/PIIS1470
spw1
in
Advanced Prostate Cancer
2 years ago
Xtandi By Its Lonesome?
Recurrent cancer; RP Jan 2019; removed 11 nodes; 3 contaminated. IMRT, Lupron for 18 months and Zytiga for 12. October 2021 Gallium PSMA scan showed one micro cancer in node behind breastbone. No ADT repetition. June PSA back 0.55. Waiting on new treatment plan. Friend is on Xtandi alone and is in
Recurrent cancer; RP Jan 2019; removed 11 nodes; 3 contaminated. IMRT, Lupron for 18 months and Zytiga for 12. October 2021 Gallium PSMA scan showed one micro cancer in node behind breastbone. No ADT repetition. June PSA back 0.55. Waiting on new treatment plan. Friend is on Xtandi alone and is in
TEBozo
in
Advanced Prostate Cancer
2 years ago
Aching bones from ADT
Recently after 9 months of an 18 month plan of ADT (Zoladex) I have started to experience what seems to be bone aching especially around my hip joints. Has anyone experienced this and if so what did you take to ease the aching? Thanks.
Recently after 9 months of an 18 month plan of ADT (Zoladex) I have started to experience what seems to be bone aching especially around my hip joints. Has anyone experienced this and if so what did you take to ease the aching? Thanks.
Runner1957
in
Prostate Cancer Network
2 years ago
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Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
I have referred to the following article a few times in response to some posts about the use and timing of ADT when used in addition (adjuvant) to improve outcomes from salvage radiation therapy for BCR for failure after primary prostate treatment (surgical or radiation or other). Also for recurrences
I have referred to the following article a few times in response to some posts about the use and timing of ADT when used in addition (adjuvant) to improve outcomes from salvage radiation therapy for BCR for failure after primary prostate treatment (surgical or radiation or other). Also for recurrences
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
I have referred to the following article a few times in response to some posts about the use and timing of ADT when used in addition (adjuvant) to improve outcomes from salvage radiation therapy for BCR for failure after primary prostate treatment (surgical or radiation or other). Also for recurrences
I have referred to the following article a few times in response to some posts about the use and timing of ADT when used in addition (adjuvant) to improve outcomes from salvage radiation therapy for BCR for failure after primary prostate treatment (surgical or radiation or other). Also for recurrences
MateoBeach
in
Fight Prostate Cancer
2 years ago
Treatment recommendation
Soon starting 18 months of ADT and salvage radiation and my Oncologist is giving me the choice between Lupron/Casodex or Orgovyx. I'm leaning towards Orgovyx. Does anyone have any thoughts between the two? Thanks!
Soon starting 18 months of ADT and salvage radiation and my Oncologist is giving me the choice between Lupron/Casodex or Orgovyx. I'm leaning towards Orgovyx. Does anyone have any thoughts between the two? Thanks!
dlste353
in
Fight Prostate Cancer
2 years ago
HMB
In the recent "Losing Muscles" thread (https://healthunlocked.com/advanced-prostate-cancer/posts/148152168/loosing-muscles), some of the responses mentioned and briefly discussed HMB use as a supplement to combat muscle loss associated with ADT. I'm alert to this subject because, in spite of spending
In the recent "Losing Muscles" thread (https://healthunlocked.com/advanced-prostate-cancer/posts/148152168/loosing-muscles), some of the responses mentioned and briefly discussed HMB use as a supplement to combat muscle loss associated with ADT. I'm alert to this subject because, in spite of spending
Gearhead
in
Advanced Prostate Cancer
2 years ago
Are MRI with coil and biopsy needed for BCR recurrence in prostate for cryotherapy, HIFU, Tulsa Pro or Brachytherapy?
After posting questions on ADT options for BCR oligometastasis, we have new development/input from RO and MO which makes us delay starting hormone therapy now. We would really appreciate members' input and advice so that we can make informed decision. Brief background, my husband was diagnosed in Dec
After posting questions on ADT options for BCR oligometastasis, we have new development/input from RO and MO which makes us delay starting hormone therapy now. We would really appreciate members' input and advice so that we can make informed decision. Brief background, my husband was diagnosed in Dec
TCMG
in
Advanced Prostate Cancer
2 years ago
Extracts from two papers on exercise and cancer. Paper 1 investigates the blood from 25 patients with mCRPC exercising. Paper 2 is a review.
The first paper indicates that a phase 3 trial INTERVAL-GAP4 is recruiting. I have not checked this. The patients used in this study were recruited to the INTERVAL-GAP4 trial (2016- 2020). I include the Abstract and the section about the exercise program used. I include the extract from the second paper
The first paper indicates that a phase 3 trial INTERVAL-GAP4 is recruiting. I have not checked this. The patients used in this study were recruited to the INTERVAL-GAP4 trial (2016- 2020). I include the Abstract and the section about the exercise program used. I include the extract from the second paper
Graham49
in
Advanced Prostate Cancer
2 years ago
ADT options for BCR oligometastesis
Recent Auxmin and PSMA scans show that my husband has BCR oligometastesis (MRI shows nothing). It seems there are two different treatment options/opinions: 1. Lupron OR Eligard OR Firmagon OR Orgovyx for a few months and then radiation, then continue hormone therapy for 1-1.5 years 2. Lupron OR Eligard
Recent Auxmin and PSMA scans show that my husband has BCR oligometastesis (MRI shows nothing). It seems there are two different treatment options/opinions: 1. Lupron OR Eligard OR Firmagon OR Orgovyx for a few months and then radiation, then continue hormone therapy for 1-1.5 years 2. Lupron OR Eligard
TCMG
in
Advanced Prostate Cancer
2 years ago
Loosing muscles
During last 8 years on ADT, and last 2 years of Xtandi, I am facing continious loosing muscles, as well as weight, of course. Bones metastases prevent me regular training, exept walking dogs few times daily. Any contribution of the way of gaining muscles, or just stoping melting them further, would
During last 8 years on ADT, and last 2 years of Xtandi, I am facing continious loosing muscles, as well as weight, of course. Bones metastases prevent me regular training, exept walking dogs few times daily. Any contribution of the way of gaining muscles, or just stoping melting them further, would
beogradjanin
in
Advanced Prostate Cancer
2 years ago
phase 3 trial of SHR3630 versus bicalutamide in combination with androgen deprivation therapy (ADT) in patients with high-volume metastatic
Publish DateJune 17, 2022 Renal and Urology News Novel Drug Improves Outcomes vs Bicalutamide in Metastatic Hormone-Sensitive Prostate Cancer Jody A. Charnow Share on Facebook Share on Twitter Share on LinkedIn Share on Reddit Print Share by Email SHR3680 plus ADT improved radiographic progression-free
Publish DateJune 17, 2022 Renal and Urology News Novel Drug Improves Outcomes vs Bicalutamide in Metastatic Hormone-Sensitive Prostate Cancer Jody A. Charnow Share on Facebook Share on Twitter Share on LinkedIn Share on Reddit Print Share by Email SHR3680 plus ADT improved radiographic progression-free
Graham49
in
Advanced Prostate Cancer
2 years ago
Acute, major depression after 3-month Lupron injection, from a new poster
I haven't posted my prostate cancer bio here yet but I intend to in the future. I had a prostatectomy along with my seminal vesicles and the left side lymph nodes proximal to the prostate. Gleason 4+3 N0. The cancer had escaped the prostate which could only partial be removed since it was microscopic
I haven't posted my prostate cancer bio here yet but I intend to in the future. I had a prostatectomy along with my seminal vesicles and the left side lymph nodes proximal to the prostate. Gleason 4+3 N0. The cancer had escaped the prostate which could only partial be removed since it was microscopic
maggiedrum
in
Advanced Prostate Cancer
2 years ago
Switching from Firmagon to Lucrin or Eligard
Hi, this is ALEX from Malaysia. First Dx 2016 psa 8.34, gs 3+4. Had RP 10/2017 with positive margin. Did salvage IMRT 8/4/2019 at psa 2.43 without adt. After 2nd Bcr post Salvage RT, psa rose from 0.05 to 0.94 , I started on FIRMAGON on 8/ 3/ 2022. ( Throughout this 5 1/2 year journey, a total of 4
Hi, this is ALEX from Malaysia. First Dx 2016 psa 8.34, gs 3+4. Had RP 10/2017 with positive margin. Did salvage IMRT 8/4/2019 at psa 2.43 without adt. After 2nd Bcr post Salvage RT, psa rose from 0.05 to 0.94 , I started on FIRMAGON on 8/ 3/ 2022. ( Throughout this 5 1/2 year journey, a total of 4
huraymond
in
Advanced Prostate Cancer
2 years ago
Eligard Question
Hi all. I've had two injections 3 months apart, so the end of this month is the end of my 6-month ADT treatment for now. Currently experiencing moderate but uncomfortable breast swelling and wondering if this will be a reversible condition? If so, will it resolve on its own or will I need to contact
Hi all. I've had two injections 3 months apart, so the end of this month is the end of my 6-month ADT treatment for now. Currently experiencing moderate but uncomfortable breast swelling and wondering if this will be a reversible condition? If so, will it resolve on its own or will I need to contact
ixolib
in
Advanced Prostate Cancer
2 years ago
Statins and ADT
Are there statins that extend mortality if taken with ADT in advanced metastatic pica?
Are there statins that extend mortality if taken with ADT in advanced metastatic pica?
Researchshortcut
in
Advanced Prostate Cancer
2 years ago
Thyroid hormone treatment intensity linked to increased risk of cardiovascular mortality
Just how long can this go on? Positively defining in terms of TSH alone. "… exogenous hyperthyroidism or hypothyroidism, which is having thyrotropin levels inappropriately below or above the normal range". And then going to to suggest it is the thyrotropin level which is the cause? Without having even
Just how long can this go on? Positively defining in terms of TSH alone. "… exogenous hyperthyroidism or hypothyroidism, which is having thyrotropin levels inappropriately below or above the normal range". And then going to to suggest it is the thyrotropin level which is the cause? Without having even
helvella
Thyroid UK
in
Thyroid UK
2 years ago
SHBG slightly elevated
Any thoughts on why SHBG is slightly high? Sex Hormone Binding Globulin Your Value=78 nmol/L Standard Range= 19 - 76 nmol/L . ComponentYour ValueStandard Range Testosterone, Free, Calc<1 pg/mL 47 - 244 pg/mL INTERPRETIVE INFORMATION: Testosterone, Free Calculation Free testosterone concentration
Any thoughts on why SHBG is slightly high? Sex Hormone Binding Globulin Your Value=78 nmol/L Standard Range= 19 - 76 nmol/L . ComponentYour ValueStandard Range Testosterone, Free, Calc<1 pg/mL 47 - 244 pg/mL INTERPRETIVE INFORMATION: Testosterone, Free Calculation Free testosterone concentration
Scout4answers
in
Advanced Prostate Cancer
2 years ago
GA 68 PSMA PET SCAN RESULTS
My PSA reading 3 months after RALP was 8.11. I started Cosadex on June 1st, and Eligard 30mg 4 month injection on the 13th. I just received the results of my PSMA Pet Scan. 1. Hypermetabolic nodules/lymph nodes in the mid pelvis, consistent with sites of residual/recurrent viable disease. The most suspicious
My PSA reading 3 months after RALP was 8.11. I started Cosadex on June 1st, and Eligard 30mg 4 month injection on the 13th. I just received the results of my PSMA Pet Scan. 1. Hypermetabolic nodules/lymph nodes in the mid pelvis, consistent with sites of residual/recurrent viable disease. The most suspicious
GMan-62
in
Advanced Prostate Cancer
2 years ago
Docetaxel PSA decreased but new bone mets
Hi, I'm a 65yo, I had my initial diagnosis in Feb 2022 with 1000PSA, Gleason 8, metastatic prostate cancer with pulmonary, pelvic node, and bone involvement ( pelvis, spine, ribs). I started my therapy in March with ADT + Docetaxel every 28/21days. PSA dropped to 13 last month and to 3 last week. I
Hi, I'm a 65yo, I had my initial diagnosis in Feb 2022 with 1000PSA, Gleason 8, metastatic prostate cancer with pulmonary, pelvic node, and bone involvement ( pelvis, spine, ribs). I started my therapy in March with ADT + Docetaxel every 28/21days. PSA dropped to 13 last month and to 3 last week. I
Rafa2
in
Advanced Prostate Cancer
2 years ago
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