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Phase III Study: Saruparib Combo with New Hormonal Agents in mCSPC +/- HRR Mutations: AUA 2024 EvoPAR-Prostate01 Trial
AUA 2024: EvoPAR-Prostate01: Phase III, Double-Blind, Placebo-Controlled, 2-Cohort, Randomized Study of Saruparib (AZD5305) in Combination with New Hormonal Agents in Patients with mCSPC +/- HRR Mutations (UroToday.com) The 2024 American Urological Association (AUA) annual meeting featured a session
AUA 2024: EvoPAR-Prostate01: Phase III, Double-Blind, Placebo-Controlled, 2-Cohort, Randomized Study of Saruparib (AZD5305) in Combination with New Hormonal Agents in Patients with mCSPC +/- HRR Mutations (UroToday.com) The 2024 American Urological Association (AUA) annual meeting featured a session
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
Any guidance appreciated!
Hi everyone, My Dad (77) diagnosed in January w/ stage 4 PC, mets to L5 spine. PET scan showed no other spots elsewhere. PSA was 19 at time of diagnosis, Gleason 10. BRCA negative. PSA is now at 0.2 since starting hormone therapy. Feeling good, no pain. Still works (owns his own company). Started
Hi everyone, My Dad (77) diagnosed in January w/ stage 4 PC, mets to L5 spine. PET scan showed no other spots elsewhere. PSA was 19 at time of diagnosis, Gleason 10. BRCA negative. PSA is now at 0.2 since starting hormone therapy. Feeling good, no pain. Still works (owns his own company). Started
LDC2024
in
Advanced Prostate Cancer
2 months ago
oligometastic
I had a PSMA scan that found 3 small spots. My MO and Radiation O decided to radiate the spots without ADT. PSA is 0.28
I had a PSMA scan that found 3 small spots. My MO and Radiation O decided to radiate the spots without ADT. PSA is 0.28
Howard53545
in
Advanced Prostate Cancer
2 months ago
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TRAP trial: radiotherapy combined with hormone therapy can help some advanced prostate cancer patients avoid chemotherapy
TRAP is maybe not the best name for a clinical trial, but hey… https://www.icr.ac.uk/news-archive/new-trial-finds-radiotherapy-combined-with-hormone-therapy-can-help-some-advanced-prostate-cancer-patients-avoid-chemotherapy
TRAP is maybe not the best name for a clinical trial, but hey… https://www.icr.ac.uk/news-archive/new-trial-finds-radiotherapy-combined-with-hormone-therapy-can-help-some-advanced-prostate-cancer-patients-avoid-chemotherapy
Maxone73
in
Advanced Prostate Cancer
2 months ago
A-Dream iADT Protocol
It has been awhile since my last post. Short story is I responded well to the doublet therapy in Arasec (lupron+daro). MO believes there is some chance my M1B diagnosis at the start was incorrect (he refers to my case as 'discordant' - due to conflicting data - Gleason 6 but some spots lit up on
It has been awhile since my last post. Short story is I responded well to the doublet therapy in Arasec (lupron+daro). MO believes there is some chance my M1B diagnosis at the start was incorrect (he refers to my case as 'discordant' - due to conflicting data - Gleason 6 but some spots lit up on
Heykm01
in
Advanced Prostate Cancer
2 months ago
Walsh's Folly?
I posted earlier that I had to ask ChatGPt "who came up with the 'gasoline on a fire' characterization regarding the relationship of testosterone and prostate cancer" and that Chat GPT had answered -- Dr. Patrick Walsh -- (father of the radical prostatectomy.) In that post, discussion turned to Walsh's
I posted earlier that I had to ask ChatGPt "who came up with the 'gasoline on a fire' characterization regarding the relationship of testosterone and prostate cancer" and that Chat GPT had answered -- Dr. Patrick Walsh -- (father of the radical prostatectomy.) In that post, discussion turned to Walsh's
VoxHope
in
Advanced Prostate Cancer
2 months ago
Celebrex and Curcumin and Magnesium.
I recently received a question from a fellow warrior based on a comment I had made on an older post that he had started. The question was what I thought about Naproxen compered to Celebrex and I told him I had very limited experience with Naproxen. I then clicked on older posts about nsaids and prostate
I recently received a question from a fellow warrior based on a comment I had made on an older post that he had started. The question was what I thought about Naproxen compered to Celebrex and I told him I had very limited experience with Naproxen. I then clicked on older posts about nsaids and prostate
Professorgary
in
Advanced Prostate Cancer
2 months ago
"Gasoline" Source
I have been trying to find the source for the observation? that "Testosterone to prostate cancer is like gasoline on a fire". I finally asked Bing Copilot and ChatGPT-- who came up with the answer. Me: What is the source of the "gasoline on a fire" theory in prostate cancer? ChatGPT: Dr. Patrick
I have been trying to find the source for the observation? that "Testosterone to prostate cancer is like gasoline on a fire". I finally asked Bing Copilot and ChatGPT-- who came up with the answer. Me: What is the source of the "gasoline on a fire" theory in prostate cancer? ChatGPT: Dr. Patrick
VoxHope
in
Advanced Prostate Cancer
2 months ago
What comes after, what comes next?
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
lgutman
in
Advanced Prostate Cancer
2 months ago
ADT + Docetaxel
Am mCRPC and will be starting Docetaxel soon, after apparent failure of Zytiga. Would like to know if I should continue the ADT (zoladex), which I have tolerated well for 3 years. Most trial info I have found (STAMPEDE, CHAARTED) tests ADT alone vs ADT + Docetaxel, where the combination outcome is
Am mCRPC and will be starting Docetaxel soon, after apparent failure of Zytiga. Would like to know if I should continue the ADT (zoladex), which I have tolerated well for 3 years. Most trial info I have found (STAMPEDE, CHAARTED) tests ADT alone vs ADT + Docetaxel, where the combination outcome is
Ian99
in
Advanced Prostate Cancer
2 months ago
ADT & Pluvicto
Is it common to continue ADT treatments, like Lupron or Eligard, while receiving Pluvicto therapy?
Is it common to continue ADT treatments, like Lupron or Eligard, while receiving Pluvicto therapy?
Shams_Vjean
in
Advanced Prostate Cancer
2 months ago
Input on Timing of Initial ADT after RP/SRT Failed
After surgery and salvage radiation therapy (SRT) have failed, it appears I'm headed for androgen deprivation therapy. Like many things in the world of prostate cancer, the recommendations as to when to start ADT seem to be all over the place, so I'm seeking any insights folks may have based on your
After surgery and salvage radiation therapy (SRT) have failed, it appears I'm headed for androgen deprivation therapy. Like many things in the world of prostate cancer, the recommendations as to when to start ADT seem to be all over the place, so I'm seeking any insights folks may have based on your
dans_journey
in
Advanced Prostate Cancer
2 months ago
Salvage options?
Hello again, I have a few more questions, to help my husband decide between surgery and brachyboost. For context, he is localized Gleason 9. (1) Is the course of salvage radiation after RP typically the same as it would have been if the initial treatment had been radiation therapy? Or would it require
Hello again, I have a few more questions, to help my husband decide between surgery and brachyboost. For context, he is localized Gleason 9. (1) Is the course of salvage radiation after RP typically the same as it would have been if the initial treatment had been radiation therapy? Or would it require
EvFC
in
Advanced Prostate Cancer
3 months ago
If you are thinking of Travel - Go For It.
Hello everyone, We're midway through our 10-week holiday adventure, and it's been quite a journey so far! From Japan to Finland, Turkey, and now Italy, we've covered quite a bit of ground. Traveling alongside another couple, our time in Turkey stands out, where I took on the role of designated driver
Hello everyone, We're midway through our 10-week holiday adventure, and it's been quite a journey so far! From Japan to Finland, Turkey, and now Italy, we've covered quite a bit of ground. Traveling alongside another couple, our time in Turkey stands out, where I took on the role of designated driver
Mike58
in
Prostate Cancer Network
3 months ago
Guess what? Your body has changed and will never be the same.
I recently read a post from a guy that stated he had muscle and stamina loss. The post and responses then went on in a very hand wringing way to ask and discuss things like, “should I eat whey”, “what about protein and in what form”, “I never eat or drink dairy products”. It then went on to lament all
I recently read a post from a guy that stated he had muscle and stamina loss. The post and responses then went on in a very hand wringing way to ask and discuss things like, “should I eat whey”, “what about protein and in what form”, “I never eat or drink dairy products”. It then went on to lament all
OldGuysRule
in
Advanced Prostate Cancer
3 months ago
Long complicated paper on gut microbiome and PCa, human and mouse studies.
The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids Nature Communications volume 15, Article number: 3431 (2024) PMID: 38654015 PMCID: PMC11039720 DOI: 10.1038/s41467-024-45332-w Some snippets from the paper: ”Hypercaloric diets, such as
The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids Nature Communications volume 15, Article number: 3431 (2024) PMID: 38654015 PMCID: PMC11039720 DOI: 10.1038/s41467-024-45332-w Some snippets from the paper: ”Hypercaloric diets, such as
Graham49
in
Advanced Prostate Cancer
3 months ago
Surgery or radiation, looking for some advices
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Healing1826
in
Advanced Prostate Cancer
3 months ago
Newbie on PCa, coping on PCa
Hi, bump into this forum and in general trying to reach out to learn on any restriction on sugar, dairy . eggs and generally what sort of food should be taking. putting on weight - with ADT and how best to manage this...feeling so tired on ADT, even while typing this. must appreciated.
Hi, bump into this forum and in general trying to reach out to learn on any restriction on sugar, dairy . eggs and generally what sort of food should be taking. putting on weight - with ADT and how best to manage this...feeling so tired on ADT, even while typing this. must appreciated.
ahmadyusriyahaya
in
Advanced Prostate Cancer
3 months ago
PC drug with least side effects
After 2 years on ADT I must go to a stronger medicine. I am castrate resistant with one small met by the pelvis. Doc suggests Xthandi but I would appreciate any suggestions on anything easier. The SE scare the hell out of me
After 2 years on ADT I must go to a stronger medicine. I am castrate resistant with one small met by the pelvis. Doc suggests Xthandi but I would appreciate any suggestions on anything easier. The SE scare the hell out of me
Stevegr
in
Advanced Prostate Cancer
3 months ago
Exercise on ADT? You’ll want to hear this.
skip to 2:16:00 https://youtu.be/AVOKWvYJM-c?si=BdUZ0Rc5yULvTfgX
skip to 2:16:00 https://youtu.be/AVOKWvYJM-c?si=BdUZ0Rc5yULvTfgX
No_stone_unturned
in
Advanced Prostate Cancer
3 months ago
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