Any ideas prolactin, cortisol,fsh,lh,overange, oestradiol <18,ferritin 57,overange iron/transferrin with varying thyroid results please?

[Jo5454]

Hi,Have posted on here before with confusing thyroid results tsh has varied from 0.96-6, seems to have settled few years 3ish.

Ft4 back upto 16.9 (12-22),was 12.

Ft3 raised back up to 5.8 (3.1-6.8)

Antibodies all fine.

Health still poor, very tired, dry face, cold, underweight, foggy, achey, no stamina, breathless to name a few but neuro symptoms improving after a year on b12 inj due to functional def-Mch remains overange.

Lymphocytes under, neutrophils slightly over.

Folate jumped from 8 to 25 in fortnight.

Cortisol am 769-overange.

Dhea-3.7 (0.96-6.95)

Active b12>150

Vit d 58nmol-on 1000iu daily, will now double?

Prolactin 779(102-496)- been advised to retest in 4 weeks. Have read can be due to low b6/ vit d? As well as pituitary issues?

Will post hormones as seems these are due to menopause.(age 51)

Regular periods until Nov, then 1 lasted 3 1/2 weeks. Now getting just a break of 1 or 2 weeks inbetween bleeding, but it's getting lighter.

Any advice on next moves please? Assumed I'd be in need of iron supplements after losing more blood & ferritin not rising? But seems not.

Awaiting ent appt for very large nasak polyps/op & had very stressful times with 2 close family deaths. On gluten/dairy free diets due to borderline gliadin, milk intolerance.

Any ideas im any direction greatly appreciated thank you.

[SlowDragon Administrator]

20% of hashimoto’s patients never have high antibodies

have you had ultrasound scan may get you a diagnosis

healthunlocked.com/thyroidu...

High prolactin relatively common with Hashimoto’s

Gluten and Dairy intolerance suggests Hashimoto’s

Have you tested BOTH TPO And Thyroglobulin antibodies

NHS won’t test TG antibodies if TPO antibodies are negative

You would need to test privately

Presumably you’re not on replacement thyroid hormones?

You get B12 injections?

Do you have PA?

Are you taking daily B complex as well

Yes vitamin D is far too low

Suggest you get vitamin D mouth spray and increase to 2000iu daily

Retest in 3-4 months

There’s a version made that also contains vitamin K2 Mk7.

One spray = 1000iu

amazon.co.uk/BetterYou-Dlux...

Web links about taking important cofactors - magnesium and Vit K2-MK7

Magnesium best taken in the afternoon or evening, but must be four hours away from levothyroxine

betterbones.com/bone-nutrit...

medicalnewstoday.com/articl...

livescience.com/61866-magne...

sciencedaily.com/releases/2...

Vitamin K2 mk7

betterbones.com/bone-nutrit...

healthline.com/nutrition/vi...

Helpful to add your age on profile and a short summary of what diagnosed and what meds etc

[Jo5454 in reply to SlowDragon]

Many thanks slowdragon for your time and help.I've just turned 51. I didn't realise prolactin could be higher due to hashimotos, thank you. I've tested antibodies via pinprick and venous oncevavyear for a fairvfew years but they are akways the same, one us around 9, the other in the 20's.

Yes, youre right, maybe I'll have to arrange a private ultrasound next, have asked Dr in past but they've said not necessary. At least it would either rule it out or show up.

No, not on thyroid hormones. Last year I queried it with Dr when t4 & t3 30ish % through range, but he said all is fine.

I have a functional b12 defic,paid & diagnosed by low Active b12/high methlemonic acid/severe neuro symptoms. Yes, for last 6 months got monthly inj back from NHS.

Intrinsic factor only tested once, negative.

Will up vit d further thanks, yes, have taken vit k alongside in past, will get some again. Can't have spray, but have what i presume to be a good additive free one. It has given me bad headaches in higher doses, but will increase gradually & see.

Use a magnesium spray at night.

Thanks fir your advice.

Can I ask your thoughts please on the iron situation, really not sure whether to supplement...many thanks.

[SlowDragon Administrator in reply to Jo5454]

What are latest iron panel results

[Jo5454 in reply to SlowDragon]

Thanks Slowdragon. I had these done at local hospita venouslyl via private. It was part of an advanced blood test and thankfully provided a result as I also did a separate iron profile, same blood draw, ferritin was 55 on that and rest of testapparently had a sample error.

Iron profile

[SlowDragon Administrator in reply to Jo5454]

Iron is at top of range

If you’re taking iron supplements stop

transferrin saturation over range as well…..indicating too much iron

[Jo5454 in reply to SlowDragon]

Yes, but ferritinvwill likely drop again as soon as I do & haemoglobin recently dropped to nearer bottom of range, so did red blood cells which you think would've used more stores up?Especially with extra loss of blood recently...a bit strange to understand. Thank you.

[Jazzw]

Prolactin would likely be higher if it were a pituitary issue (in the 1000s rather than the 100s).

Your oestradiol and FSH are definitely signposting menopause. I take it you’re not on HRT at all? Or any female hormones?

What’s your ferritin level now?

You’re right about the Vit D. If you want to get that up faster you’d be ok to take 5000iu a day for a few weeks (400iu is hardly anything) before lowering it again to a maintenance dose.

[Jo5454 in reply to Jazzw]

Just checked my vit d tub, tend to decant into a pillbox...am on 1000iu a day, not 400, so that was a bit better. Will build that up higher...thank you

[Jo5454]

Thank you, that's a relief to hear. No, I'm not on any hormones. I was diagnosed with ME early twenties, though can see ferritin, b12 likely issues back then, but undiagnosed, so it's been hard along way to work out what's what. Perhaps the menopause has been hidden in amongst these more recent issues of needing b12 injections, low iron. and maybe perimenopause has been the thing making the thyroid hormones jump about?

Ferritin is mid fifties and has been that for nearly a year, apart from a dip after b12 loading dose to 35.

For few weeks September time it went from 35 to 80 to 120 back to 50's, nobsigns if infection. It's been down to single figures in past, so at least better than that. But with this extra losing of blood and low iron type symptoms I presumed iron profile would throw up a need for iron.

Thanks for vit d info, will.increase more then.

[Dellylou]

I have secondary adrenal insufficiency due to long term steroid use for a rare auto inflammatory disease which has caused me to have undetectable cortisol, as my pituitary is suppressed and doesn’t produce enough ACTH to signal my adrenal glands to produce cortisol. I would ask to be referred to an endocrinologist, perhaps an NHS centre of excellence for endocrinology where there is an endocrinologist that is more aware of pituitary related issues, the pituitary hormones you have raised could be the startings of for instance hypopituitarism, more than one pituitary hormone affected, so for instance, thyroid, prolactin and your cortisol, plus your other hormones are a little out of whack too, it’s worth going to your GP and asking for a 9am cortisol test, as at that time that is when your cortisol naturally would be at its highest and as the day progresses it drops. What time were these bloods drawn?

[Jo5454]

Thank you very much for taking the time to explain that. You must have/ had a difficult time...The test was at 8.30. I woke early at 3,have spells of that & feeling bit over revved, but got back to sleep. It was an hours journey to hospital which may not have helped, but on the past saliva tests have always shown high am cortisol. Have had blood test with gp in past but he said having a blood test is enough to spike anyone's cortisol?

Do you think one of those cortisol saliva tests coukd be helpful?

Would you expect cortisol to still drop during day if there was a pituitary problem?

Thanks very much for your help.

[humanbean]

Do you take a folate or folic acid supplement? If yes, what is it made of?

[Jo5454]

I didn't take any supplements for 2 weeks leading up to the test, then had had nhs test just before that, so actually havent really tajen any fir a month.I take a supermarket folic acid 400ug now and then. So seems odd to have jumped up to 25 considering it'd been tested hardly 3 weeks before and was 8?

Thanks...