Thyroid UK
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I'm new here - confused about tsh going up after ndt

Hi - just been taking porcine thyroid bought online for last 4 months, titrating up slowly and now on 3.5 grains. A year ago my tsh was 4.8, and I was chronically tired - have had chronic fatigue for last 8 years on and off. I followed Dr Myhill's protocol, and have found the stone age diet very helpful. I was taking iodine at 3 drops a day of a 7% solution, but stopped this about 2 weeks ago. I recently had some blood test results here:


FREE THYROXINE 13.5 pmol/L 12.00 - 22.00

TOTAL THYROXINE(T4) 92.2 nmol/L 59.00 - 154.00

FREE T3 5.82 pmol/L 3.10 - 6.80 THYROGLOBULIN ANTIBODY 84.900 IU/mL 0.00 - 115.00




VITAMIN B12 *964 pmol/L 140.00 - 724.00

FOLATE (SERUM) 13.38 ug/L 2.91 - 50.00


Inflammation Markers

CRP - HIGH SENSITIVITY 0.7 mg/l 0.00 - 5.00

Iron Status

FERRITIN 76.9 ug/L 30.00 - 400.00

The b12 was high from a supplement which I have stopped taking. What I don't understand is how my tsh has gone up when I am on 3.5 grains? and what about the antibodies? I never had them tested before, so I guess they could have been high for years. The online doctor suggested that I could slightly increase my dose if I had hypothyroid symptoms and be retested in 12 weeks. I thought to increase by 1/2 grain to 4 grains - which seems quite a lot, but the porcine I am on has less t3 than others :

Porcine: T3 2.55-4.25 mcg/grain (per 65 mg), T4 28.5-41.5 mcg/grain (per 65 mg)

so my question is why would the tsh go up, and what to do now?

I feel quite okay at the moment, even a bit hyper, but this could be emotional from just getting the blood test and worrying about it! I still get tired - probably function between 50-80% of how I was before eight years ago.I am actually feeling quite energetic, if a bit depressed and anxious at times. What to do? Many thanks,


9 Replies

What kind of thyroid treatment are you taking (brand name)?

Porcine: T3 2.55-4.25 mcg/grain (per 65 mg), T4 28.5-41.5 mcg/grain (per 65 mg)

That's a heck of a variation in dose from tablet to tablet.




Is this what you're taking? It's awfully expensive compared to real NDT - and I don't consider this to be real NDT.

However, about your TSH. You have high antibodies, which means you have Hashi's, and that's what Hashi's does : messes around with your levels. And, due to the attacks by the immune system, you could have become more hypo, and that's why your TSH has risen.


Yes, that's what I am taking. I didn't realise it was expensive - where would I get real NDT?

That's interesting about Hashi's - thanks for the info


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I would stop using iodine which has been used to decrease thyroid hormone levels in hyperthyroid patients and to raise TSH. Iodine can increase Hashimoto's flare ups.

Were you taking thyroid hormone replacement before you started using ThyroActive?

I don't see how you can be expected to become well when there is such a variance in the T4 and T3 in each batch. You might consider using Armour, WP, NatureThyroid, NP, Thyroid-S which have 38mcg T4 and 9mcg T3 per grain (60-65mg), or Erfa or Thiroyd which have 35mcg T4 and 8mcg T3.


I was not taking thyroid hormone replacement before thyroactive, although I was on nutriadvanced thyroid ( forgotten its full name) for a while before, but only tried thyroxine once about 8 years ago and it made me really ill for about a week on a low dose - but I was much weaker then. Of all those different NDTs, which would you recommend? and where could I get it?

Thanks for the advice about the iodine - I thought that might be a contributary factor - I have cut it out completely.



I'd start with Thyroid-S or Thiroyd which are the least expensive. You might have to try more than one make to find one which suits. Members who don't like Thyroid-S often find Thiroyd suits and vice verse.


Thank you for your advice - much appreciated


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