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Chemo-Free Treatment Best Option for CLL Patients Under 70
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus
rituximab
(Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine, cyclophosphamide, and
rituximab
, known as FCR.
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus
rituximab
(Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine, cyclophosphamide, and
rituximab
, known as FCR.
GlennSabin
in
CLL Support
6 years ago
Chemo-Free Treatment Best Option for CLL Patients Under 70
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus
rituximab
(Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine, cyclophosphamide, and
rituximab
, known as FCR.
Results of the phase III ECOG trial found that the combination of ibrutinib (Imbruvica) plus
rituximab
(Rituxan) came out superior to the chemotherapy and immunotherapy (chemoimmunotherapy) grouping of fludarabine, cyclophosphamide, and
rituximab
, known as FCR.
GlennSabin
in
CLL America Support
6 years ago
Had second infusion of rituximab over the 2 weeks. Last let six months ago how long before it works?
Not on any other meds! Last one was 6th December and I was hoping to feel better.
Not on any other meds! Last one was 6th December and I was hoping to feel better.
28maggie11
in
NRAS
6 years ago
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FYI/Trial data to be discussed this weekend
In CLL, there are multiple trials of interest being presented with the potential to have an impact on practice, including the phase III Alliance North American Intergroup Study A041202 exploring ibrutinib alone or in combination with
rituximab
vs standard chemoimmunotherapy with bendamustine plus
rituximab
In CLL, there are multiple trials of interest being presented with the potential to have an impact on practice, including the phase III Alliance North American Intergroup Study A041202 exploring ibrutinib alone or in combination with
rituximab
vs standard chemoimmunotherapy with bendamustine plus
rituximab
Newchallnge
in
CLL Support
6 years ago
ASH 2018: Professor Peter Hillmen on the Combination of Ibrutinib and Obinutuzumab in CLL: Timing Matters
- Conclusions It is important to remember that response rates are less critical to patients than survival data, and that adding a different older anti-CD20 antibody,
rituximab
to ibrutinib has yet to show a survival advantage.
- Conclusions It is important to remember that response rates are less critical to patients than survival data, and that adding a different older anti-CD20 antibody,
rituximab
to ibrutinib has yet to show a survival advantage.
lankisterguy
Volunteer
in
CLL Support
6 years ago
Truxima (Rituximab) Desperate for some hope and others experiences
Hi I've not posted on here since the early years of RA. I am now at a point of desperation because I feel I'm never going to get better. RA has taken over my life and I'm not coping. I've tried several treatments over the last 3 years and none of them have worked. I had my first infusion of Truxima on
Hi I've not posted on here since the early years of RA. I am now at a point of desperation because I feel I'm never going to get better. RA has taken over my life and I'm not coping. I've tried several treatments over the last 3 years and none of them have worked. I had my first infusion of Truxima on
SARAHG
in
NRAS
5 years ago
Treatments for C3G
These drugs include: o Glucocorticoids (corticosteroids, steroids) o
Rituximab
o Cyclophosphamide o Mycophenolate mofetil (MMF) o Tacrolimus o Sirolimus o Azathioprine
• Plasma exchange (plasmapheresis):
Plasma
These drugs include: o Glucocorticoids (corticosteroids, steroids) o
Rituximab
o Cyclophosphamide o Mycophenolate mofetil (MMF) o Tacrolimus o Sirolimus o Azathioprine
• Plasma exchange (plasmapheresis):
Plasma
DavidF_NKF
Administrator
in
C3 Glomerulopathy
6 years ago
Chemo Finished
At long last my final cycle of FCR has been completed, and looking back on the last six months it has been a pretty eventful journey, but I will say to all of you that are about to begin FCR treatment and those already mid treatment I do believe it has been a journey worth taking. The low points passing
At long last my final cycle of FCR has been completed, and looking back on the last six months it has been a pretty eventful journey, but I will say to all of you that are about to begin FCR treatment and those already mid treatment I do believe it has been a journey worth taking. The low points passing
dandelup
in
CLL Support
5 years ago
Flare up
Hi I’ve posted recently about
rituximab
, I had it about 4/5 weeks ago my first infusion people have said stick with it try not to get a steroid shot because I won’t know if the
rituximab
is working, I literally couldn’t get out of bed for at least half hour today all my joints are kicking of goodo nightmare
Hi I’ve posted recently about
rituximab
, I had it about 4/5 weeks ago my first infusion people have said stick with it try not to get a steroid shot because I won’t know if the
rituximab
is working, I literally couldn’t get out of bed for at least half hour today all my joints are kicking of goodo nightmare
Vonnie10
in
NRAS
6 years ago
4 Strikes (Biologics) and You're Out
After the replacements I was then put on
Rituximab
infusions for a few months and this didn't help. My feet and ankles started to get inflamed and walking started to get difficult. I was then put onto Orencia which I have been on for the last 6 months which hasn't helped.
After the replacements I was then put on
Rituximab
infusions for a few months and this didn't help. My feet and ankles started to get inflamed and walking started to get difficult. I was then put onto Orencia which I have been on for the last 6 months which hasn't helped.
Dingaan
in
NRAS
6 years ago
Anyone had change in ANA pattern? Mine gone from homogenous to negative to speckled
It’s been negative all this year then last week was positive again (despite high dose steroids, immunosuppressants and
rituximab
which I had thought was the cause of it being negative) but showed a speckled rather than homogenous pattern.
It’s been negative all this year then last week was positive again (despite high dose steroids, immunosuppressants and
rituximab
which I had thought was the cause of it being negative) but showed a speckled rather than homogenous pattern.
Melba1
in
LUPUS UK
6 years ago
Breaking news form ASH conference: looks like Ibrutinib May be better than FCR for some patients
Standard Fludarabine, Cyclophosphamide, and
Rituximab
(FCR) Chemoimmunotherapy in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL) | #leusm ash.confex.com/ash/2018/webpr…
Standard Fludarabine, Cyclophosphamide, and
Rituximab
(FCR) Chemoimmunotherapy in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL) | #leusm ash.confex.com/ash/2018/webpr…
Newchallnge
in
CLL Support
6 years ago
Late breaking CLL abstract at ASH 2018 (FCR vs IR for untreated younger patients)
https://ash.confex.com/ash/2018/webprogram/Paper120779.html CONCLUSIONS: The combination of ibrutinib and
rituximab
provides superior PFS and OS relative to FCR for patients with previously untreated CLL age ≤70.
https://ash.confex.com/ash/2018/webprogram/Paper120779.html CONCLUSIONS: The combination of ibrutinib and
rituximab
provides superior PFS and OS relative to FCR for patients with previously untreated CLL age ≤70.
avzuclav
in
CLL Support
6 years ago
Kimsome
Hello all of my CLL friends!! Happy New Year as well!! So, I was diagnosed with CLL in 2010 when I was 45 year old woman. Went through aggressive chemo, FCR. In my case the sickness now supposedly in remission but continued to make me critically ill even when it was over. If fact, I was in and out
Hello all of my CLL friends!! Happy New Year as well!! So, I was diagnosed with CLL in 2010 when I was 45 year old woman. Went through aggressive chemo, FCR. In my case the sickness now supposedly in remission but continued to make me critically ill even when it was over. If fact, I was in and out
Kimsome
in
CLL Support
5 years ago
Last cycle of FCR next week
I am on the Flair trial am now approaching my last lot of FCR. When signing up to Flair given the choice FCR would have been my last choice of treatment, but on reflection although it has been tough, I am glad it’s the arm I was given. My haematologist told me that it is still regarded as the gold standard
I am on the Flair trial am now approaching my last lot of FCR. When signing up to Flair given the choice FCR would have been my last choice of treatment, but on reflection although it has been tough, I am glad it’s the arm I was given. My haematologist told me that it is still regarded as the gold standard
dandelup
in
CLL Support
5 years ago
When do you get answers...
on top, now another round of
rituximab
.
on top, now another round of
rituximab
.
MOOG144
in
LUPUS UK
6 years ago
Flu like symptoms
Hi just need some sort of help really I had
rituximab
my first ever infusion my last one was about three weeks ago, I feel like I’ve got flu like symptoms but I never get the flu my imflamation in my wrist as goneworst I’m sleeping loads but always tired,I feel so unwell zero energy , I should say I
Hi just need some sort of help really I had
rituximab
my first ever infusion my last one was about three weeks ago, I feel like I’ve got flu like symptoms but I never get the flu my imflamation in my wrist as goneworst I’m sleeping loads but always tired,I feel so unwell zero energy , I should say I
Vonnie10
in
NRAS
6 years ago
Pneumonia injection
I need advice please on having the pneumonia injection 3 month after
Rituximab
I was diagnosed with GPA 5 years ago I had the pneumonia jab then so am due for another one After 5 years of not feeling well I am now starting to feel normal so don’t want to rock the boat I had forgotten how feeling
I need advice please on having the pneumonia injection 3 month after
Rituximab
I was diagnosed with GPA 5 years ago I had the pneumonia jab then so am due for another one After 5 years of not feeling well I am now starting to feel normal so don’t want to rock the boat I had forgotten how feeling
102637
in
Vasculitis UK
6 years ago
Transformation of CLL into prolymphocytic leukaemia
My chemo immuno therapy of Bendamustin and
Rituximab
scheduled to start on Nov 10, 2018 has to be kept on hold. as my Hb is oscillating between 9 and 10 from last 2 months.
My chemo immuno therapy of Bendamustin and
Rituximab
scheduled to start on Nov 10, 2018 has to be kept on hold. as my Hb is oscillating between 9 and 10 from last 2 months.
venk_46
in
CLL America Support
6 years ago
Flu jab
Can I have the flu jab whilst having
rituximab
infusions?
Can I have the flu jab whilst having
rituximab
infusions?
Peterborough67
in
NRAS
6 years ago
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