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When ADT fails, we continue it anyway... why not Zytiga?
This question may be more theoretical than practical, but I am curious. We use ADT to lower T and get a PSA response and regression of PC (and get symptom relief). Eventually ADT "fails" and PSA rises. But ADT continues to "succeed" in keeping T low, so we stay on it, since low T continues to be important
This question may be more theoretical than practical, but I am curious. We use ADT to lower T and get a PSA response and regression of PC (and get symptom relief). Eventually ADT "fails" and PSA rises. But ADT continues to "succeed" in keeping T low, so we stay on it, since low T continues to be important
noahware
in
Advanced Prostate Cancer
1 year ago
Timing of meds and supplements?
I wonder if anyone is able to share their optimal timing schedule- I feel like there aren’t enough hours in the day for all the different tablets with their exclusion zones! Not to mention fitting coffee into the day! This is what I currently take:
On waking:
ferograd C iron (every other day
I wonder if anyone is able to share their optimal timing schedule- I feel like there aren’t enough hours in the day for all the different tablets with their exclusion zones! Not to mention fitting coffee into the day! This is what I currently take:
On waking:
ferograd C iron (every other day
musette
in
Thyroid UK
2 years ago
Increased levothyroxine but felt worse. Back to usual dose but still so exhausted. Low iron and testosterone too. Would love advice please!
Hi and happy new year! Last time you were so helpful, thank you, wondering if anyone can help again please- Underactive thyroid / hashimotos for 7 years following first child. Was on dose of 75mcg levothyroxine and tried 100mcg under care of endocrinologist, felt worse and no more energy, also TSH
Hi and happy new year! Last time you were so helpful, thank you, wondering if anyone can help again please- Underactive thyroid / hashimotos for 7 years following first child. Was on dose of 75mcg levothyroxine and tried 100mcg under care of endocrinologist, felt worse and no more energy, also TSH
Hopetoheal22
in
Thyroid UK
1 year ago
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[Help] How to start sex life late at 24 years old (ED)
I'm 24 years old, Lawyer and brazilian. I never had any sexual intercourse. Since I was 12 years old I have always masturbated a lot and consumed a lot of pornography. In my teenager, I was always very afraid of not being able to have sexual intercourse, very anxious, ejaculating prematurely or not having
I'm 24 years old, Lawyer and brazilian. I never had any sexual intercourse. Since I was 12 years old I have always masturbated a lot and consumed a lot of pornography. In my teenager, I was always very afraid of not being able to have sexual intercourse, very anxious, ejaculating prematurely or not having
Hidden
in
Men's Health Forum (Penis Health)
2 years ago
High Dose Niacin (Nicotinic Acid) and Hashimoto's?
Update 01/22/2023: I just learned there is an increased risk of diabetes on niacin therapy: https://heart.bmj.com/content/102/3/198 This study was based on people taking Niacin for cardiovascular reasons, which I think would be dosed at 500 to 6000 mg a day: https://www.mayoclinic.org/drugs-supplements
Update 01/22/2023: I just learned there is an increased risk of diabetes on niacin therapy: https://heart.bmj.com/content/102/3/198 This study was based on people taking Niacin for cardiovascular reasons, which I think would be dosed at 500 to 6000 mg a day: https://www.mayoclinic.org/drugs-supplements
Bolt_Upright
in
Thyroid UK
2 years ago
Covid-Induced Holiday
A week before Christmas, both my wife and I tested positive for Covid and it was the first time for both of us. My Primary Care wanted to put my on Paxlovid for 5 days but was concerned about interactions with my Orgovyx and Lipitor. Both should be stopped during the 5 days on Paxlovid and then for 7
A week before Christmas, both my wife and I tested positive for Covid and it was the first time for both of us. My Primary Care wanted to put my on Paxlovid for 5 days but was concerned about interactions with my Orgovyx and Lipitor. Both should be stopped during the 5 days on Paxlovid and then for 7
jcarey79
in
Advanced Prostate Cancer
2 years ago
muscle and ADT issues and questions
A question about side effects and Zoladex (goserelin) - I am into the third month of Zoladex and two previous months prior to this on Bicalutimide (casodex) following a MRI and biopsy Gleason 9 (T2cN0M0) last august after HIFU for G7 only 8 months prior didn’t stop PSA rise. Just completed 20 sessions
A question about side effects and Zoladex (goserelin) - I am into the third month of Zoladex and two previous months prior to this on Bicalutimide (casodex) following a MRI and biopsy Gleason 9 (T2cN0M0) last august after HIFU for G7 only 8 months prior didn’t stop PSA rise. Just completed 20 sessions
SimMartin
in
Prostate Cancer Network
2 years ago
burning from estradiol vag cream
I've been prescribed a generic estradiol vaginal cream for vaginal atrophy due to menopause. I'm actually still in perimenopause but about 4 years ago (age 46) I began to get UTI's after intercourse and would feel irritated and itchy also. It's just gotten worse over time and now it's really bad.
I've been prescribed a generic estradiol vaginal cream for vaginal atrophy due to menopause. I'm actually still in perimenopause but about 4 years ago (age 46) I began to get UTI's after intercourse and would feel irritated and itchy also. It's just gotten worse over time and now it's really bad.
sungirl55
in
Menopause and Perimenopause Support
2 years ago
Should I be worried?
Hello my brothers and sisters. After 3 years of ADT (Zoladex) and with a stable PSA of .13, my MO put me on vacation (to my great joy) I June, 2022. It has now been 5 months. Three months into my vacatión I could begin to feel the changes with greater strength, muscle mass and hope, although the hot
Hello my brothers and sisters. After 3 years of ADT (Zoladex) and with a stable PSA of .13, my MO put me on vacation (to my great joy) I June, 2022. It has now been 5 months. Three months into my vacatión I could begin to feel the changes with greater strength, muscle mass and hope, although the hot
CountryJoe
in
Advanced Prostate Cancer
2 years ago
BATMAN
Yesterday, when I complained of the apparent lack of interest in using BAT to prevent CRPC, I should have briefly mentioned the old BATMAN study (2016). Although BATMAN involved hormone-sensitive men, there was no castration phase. Therefore, the BATMAN protocol was not designed to prevent CRPC.
Yesterday, when I complained of the apparent lack of interest in using BAT to prevent CRPC, I should have briefly mentioned the old BATMAN study (2016). Although BATMAN involved hormone-sensitive men, there was no castration phase. Therefore, the BATMAN protocol was not designed to prevent CRPC.
pca2004
in
Fight Prostate Cancer
2 years ago
Michael T Schweizer & BAT [Bipolar Androgen Therapy
I was looking at BAT-related studies involving Dr. Schweizer. The first was as lead author for Denmeade (2015). Most BAT research has been performed on men with CRPC [Castrate-Resistant Prostate Cancer]. The U.S. statistics for 2022 were 268,490 new cases, with 34,500 deaths. The deaths being largely
I was looking at BAT-related studies involving Dr. Schweizer. The first was as lead author for Denmeade (2015). Most BAT research has been performed on men with CRPC [Castrate-Resistant Prostate Cancer]. The U.S. statistics for 2022 were 268,490 new cases, with 34,500 deaths. The deaths being largely
pca2004
in
Fight Prostate Cancer
2 years ago
Should I worry about testosterone increase?
My father has been on Lupron for about a year. My father, who had oligometastatic prostate cancer, underwent robotic surgery in September. Before surgery,
PSA was 0.0311 and total testosterone was <0.025.
Two months after the surgery,
PSA was undetectable b
ut total
testosterone was 0.0707
My father has been on Lupron for about a year. My father, who had oligometastatic prostate cancer, underwent robotic surgery in September. Before surgery,
PSA was 0.0311 and total testosterone was <0.025.
Two months after the surgery,
PSA was undetectable b
ut total
testosterone was 0.0707
Alicee92
in
Advanced Prostate Cancer
2 years ago
How long will "4 month" lupron injection "last"
I received a 4 month lupron injection on 8/15/22 with salvage radiation to prostate bed and pelvic lymph nodes. (see profile for more details) My question is how long will the lupron keep my testosterone at castrate levels (<50 ng). Note my pre lupron injection testosterone level was 906 on 7/22/22
I received a 4 month lupron injection on 8/15/22 with salvage radiation to prostate bed and pelvic lymph nodes. (see profile for more details) My question is how long will the lupron keep my testosterone at castrate levels (<50 ng). Note my pre lupron injection testosterone level was 906 on 7/22/22
FlyJ
in
Advanced Prostate Cancer
2 years ago
Metabolic Syndrome & Survival
New study from China below [1]. Note: "MetS" = Metabolic Syndrome; "mPCA" = metastatic PCa. "190 patients diagnosed with mPCA by pathology and imaging from January 2010 to August 2021 ... including 111 cases in the MetS group and 79 cases in the Non-MetS group." "Those with mPCA combined with MetS
New study from China below [1]. Note: "MetS" = Metabolic Syndrome; "mPCA" = metastatic PCa. "190 patients diagnosed with mPCA by pathology and imaging from January 2010 to August 2021 ... including 111 cases in the MetS group and 79 cases in the Non-MetS group." "Those with mPCA combined with MetS
pca2004
in
Fight Prostate Cancer
2 years ago
BAT+ Olaparib in men with CRPC
New paper below [1]. Michael Schweizer is not as well-known as Samuel Denmeade to those interested in BAT. Here he is speaking to Alicia Morgans a year ago. https://www.urotoday.com/video-lectures/esmo-2021/video/2307-combined-testosterone-therapy-with-olaparib-in-patients-with-metastatic-castration-resistant-prostate-cancer-michael-schweizer.html
New paper below [1]. Michael Schweizer is not as well-known as Samuel Denmeade to those interested in BAT. Here he is speaking to Alicia Morgans a year ago. https://www.urotoday.com/video-lectures/esmo-2021/video/2307-combined-testosterone-therapy-with-olaparib-in-patients-with-metastatic-castration-resistant-prostate-cancer-michael-schweizer.html
pca2004
in
Fight Prostate Cancer
2 years ago
Medications, supplements and other therapies used in Parkinsons
Here is a partial list of medication, supplements for other therapies used in Parkinsons What do you believe are the most beneficial/essential to treating Parkinsons and/or mitochondrial damage Which way should I go? Most bang for your bucks Carbadopa/Levadopa L-5-hydroxytryptophan (5-HTP) Actylcholine
Here is a partial list of medication, supplements for other therapies used in Parkinsons What do you believe are the most beneficial/essential to treating Parkinsons and/or mitochondrial damage Which way should I go? Most bang for your bucks Carbadopa/Levadopa L-5-hydroxytryptophan (5-HTP) Actylcholine
healthyheart7
in
Cure Parkinson's
2 years ago
Free testosterone
See my profile for more details on history. G9 RP 10/2013, PSA rose again over 2.5 yrs. SRT to prostate bed only. Radiation completed 8/15/16. PSA slowly rising again over the last 6 years. Last quarter PSA jumped from 0.236 to 0.364. No ADT throughout my entire PCA history. My Radiologist has
See my profile for more details on history. G9 RP 10/2013, PSA rose again over 2.5 yrs. SRT to prostate bed only. Radiation completed 8/15/16. PSA slowly rising again over the last 6 years. Last quarter PSA jumped from 0.236 to 0.364. No ADT throughout my entire PCA history. My Radiologist has
bitittle
in
Advanced Prostate Cancer
2 years ago
What first?: Provenge or Nubeqa?
I have not used 2d line AR drugs yet. CRPC just started six months ago. My PSA is below 1. One small, suspected area on last month's PSMA PET scan. That is the same area that looked suspicious on PSMA PET in 2016 and on Axumin in early 2021. I did IADT 2016-2020, with continuous ADT since Jan 2021
I have not used 2d line AR drugs yet. CRPC just started six months ago. My PSA is below 1. One small, suspected area on last month's PSMA PET scan. That is the same area that looked suspicious on PSMA PET in 2016 and on Axumin in early 2021. I did IADT 2016-2020, with continuous ADT since Jan 2021
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Boosting Low labido, Testosterone, progesterone
Has anyone taken a particular supplement or combined, mini pill or mirena coil and found it has had positive benefits on increasing labido? I feel oike my thyroid symptoms and levels are managed quite well but still no labido and that makes me sad. Scared to try anything incase it has a negative impact
Has anyone taken a particular supplement or combined, mini pill or mirena coil and found it has had positive benefits on increasing labido? I feel oike my thyroid symptoms and levels are managed quite well but still no labido and that makes me sad. Scared to try anything incase it has a negative impact
Bizzyizzy
in
Thyroid UK
2 years ago
Endo and mega high levels of oestradiol...
My cognitive issues/brain fog/inability to learn new info/feeling confused and forgetful; they are getting worse and worse. I thought these would be menopausal but my blood tests today show that I am not menopausal at all. How can this be? My oestradiol levels are 1888 pmol/L and FSH is 6.8iu/L and LH
My cognitive issues/brain fog/inability to learn new info/feeling confused and forgetful; they are getting worse and worse. I thought these would be menopausal but my blood tests today show that I am not menopausal at all. How can this be? My oestradiol levels are 1888 pmol/L and FSH is 6.8iu/L and LH
CofG
in
Endometriosis UK
2 years ago
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