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RT with ADT Relogolix (Orgovyx) vs Enzalutamide (Xtandi) Side Effect Differences?
There may not be a lot of people that can offer anecdotal reports on both as monotherapies but the reason I ask is some studies in the last 3 years are showing administration of Xtandi during Radiotherapy has shown outcomes as good as if not better than RT + ADT. https://www.sciencedirect.com/science
There may not be a lot of people that can offer anecdotal reports on both as monotherapies but the reason I ask is some studies in the last 3 years are showing administration of Xtandi during Radiotherapy has shown outcomes as good as if not better than RT + ADT. https://www.sciencedirect.com/science
jazj
in
Advanced Prostate Cancer
5 months ago
Poor egg equality, day 3 tranfer, need advice/encouragement
Questions- poor egg quality, growth hormone, day 3 transfer, and PGT testing. Sorry for the long post but hoping for some advice/encouragement. After 1 year of infertility and 2 failed IUIs, I started banking embryos at age 32 (I'm in medical training and was worried about getting pregnant before my
Questions- poor egg quality, growth hormone, day 3 transfer, and PGT testing. Sorry for the long post but hoping for some advice/encouragement. After 1 year of infertility and 2 failed IUIs, I started banking embryos at age 32 (I'm in medical training and was worried about getting pregnant before my
nf2952
in
Fertility Network UK
5 months ago
Blood test confusion
Hi there, I’ve never been formally diagnosed with endometriosis but was told by my GP at 14 that I likely had it, but there was no point in confirming as the procedure to do so was evasive, there’s no treatment except the pill, and it would all sort itself out once I got pregnant. Symptoms were long
Hi there, I’ve never been formally diagnosed with endometriosis but was told by my GP at 14 that I likely had it, but there was no point in confirming as the procedure to do so was evasive, there’s no treatment except the pill, and it would all sort itself out once I got pregnant. Symptoms were long
irishwife93
in
Endometriosis UK
5 months ago
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Restless legs.
I have severe restless legs, as previously discussed within this forum. Over the past few years intercourse has become quite painful - middle age woman syndrome. Recently my GP started me on 10 milligrams estradiol vagifem pessaries. I understand that hrt has a significant impact on rls. My rls was
I have severe restless legs, as previously discussed within this forum. Over the past few years intercourse has become quite painful - middle age woman syndrome. Recently my GP started me on 10 milligrams estradiol vagifem pessaries. I understand that hrt has a significant impact on rls. My rls was
Trish8433
in
Restless Legs Syndrome
8 months ago
Is there such a thing as too fast of a recovery of T on iADT 🫨
After 2 years of ADT, I decided against continuing on that for life and to initiate iADT. Otherwise known as "taking a vacation".I am now 10 weeks without ADT, and my testosterone is already at 104. My questions this time are for others here who have had a similarly quick return of testosterone. I
After 2 years of ADT, I decided against continuing on that for life and to initiate iADT. Otherwise known as "taking a vacation".I am now 10 weeks without ADT, and my testosterone is already at 104. My questions this time are for others here who have had a similarly quick return of testosterone. I
Lewellen
in
Advanced Prostate Cancer
5 months ago
PSA vs Testosterone plot has large scatter, but still confirms Morgentaler's Saturation Model.
Here are two plots comparing PSA values to Testosterone levels taken from a pair of large data sets. What is striking is the large amount of scatter in the individual data from both datasets, with factors of 2-6 X deviations from the average (or median) values. The upper plot has N = 255 data points
Here are two plots comparing PSA values to Testosterone levels taken from a pair of large data sets. What is striking is the large amount of scatter in the individual data from both datasets, with factors of 2-6 X deviations from the average (or median) values. The upper plot has N = 255 data points
janebob99
in
Prostate Cancer Network
5 months ago
Low-T is associated with worse Prostate Cancer Specific Mortality probability after 6 months of ADT: Part III
Here are comparisons of the
Prostate Cancer Specific Mortality (PCSM) probability (%
) for two different testosterone levels (
Low-T and Normal-T
) and four different
Times After PSA Failure
from the Kaplan-Meier plot previously posted. (Atkins 2018). The median testosterone for
Here are comparisons of the
Prostate Cancer Specific Mortality (PCSM) probability (%
) for two different testosterone levels (
Low-T and Normal-T
) and four different
Times After PSA Failure
from the Kaplan-Meier plot previously posted. (Atkins 2018). The median testosterone for
janebob99
in
Prostate Cancer Network
5 months ago
Low-T is associated with worse Prostate Cancer Specific Mortality probability after 6 months of ADT: Part II
Here are comparisons of the Prostate Cancer Specific Mortality (PCSM) probability (%) for two different testosterone levels (Low-T and Normal-T)and three different Times After PSA Failure from Atkins (2018). he median testosterone for the Low-T group is T = 162 ng/dL [120-236], and I assumed an average
Here are comparisons of the Prostate Cancer Specific Mortality (PCSM) probability (%) for two different testosterone levels (Low-T and Normal-T)and three different Times After PSA Failure from Atkins (2018). he median testosterone for the Low-T group is T = 162 ng/dL [120-236], and I assumed an average
janebob99
in
Prostate Cancer Network
5 months ago
Updating my husband's journey, hoping it helps others - any words of encouragement are welcome, but please only positive comments
The first part is in my profile. It makes me feel vulnerable to share, but we have benefited enormously from reading others' stories, so I'm sharing. UPDATE: 8/18/21 PSA =0.45 9/6/21 last dose Orgovyx 9/7/21 First Eligard 3 month shot 9/17/21 PSA =0.78 10/18/21 PSA =1.28 Nov not tested 12
The first part is in my profile. It makes me feel vulnerable to share, but we have benefited enormously from reading others' stories, so I'm sharing. UPDATE: 8/18/21 PSA =0.45 9/6/21 last dose Orgovyx 9/7/21 First Eligard 3 month shot 9/17/21 PSA =0.78 10/18/21 PSA =1.28 Nov not tested 12
SuppWife
in
Advanced Prostate Cancer
5 months ago
Magnesium, zinc and calcium
Nearly a year after ADT and all clear with testosterone recovering well. Been advised by a fellow runner to try a supplement of magnesium, zinc and calcium. The Onco has no objections. Are there reasons no too? Thank you.
Nearly a year after ADT and all clear with testosterone recovering well. Been advised by a fellow runner to try a supplement of magnesium, zinc and calcium. The Onco has no objections. Are there reasons no too? Thank you.
Runner1957
in
Prostate Cancer Network
5 months ago
WORRIED ABOUT REOCCURRENCE???
Worried....
Stopped IMRT 1 year ago and stopped adt (4 mos) 9 months ago...
9/23/23 Blood Test PSA .1 --- PSA FREE undetectable and Testosterone was 98
3/4/24 Blood Test PSA .2 ----Psa Free Undetectable and Testosterone not in yet.
I am concerned about the increase
Worried....
Stopped IMRT 1 year ago and stopped adt (4 mos) 9 months ago...
9/23/23 Blood Test PSA .1 --- PSA FREE undetectable and Testosterone was 98
3/4/24 Blood Test PSA .2 ----Psa Free Undetectable and Testosterone not in yet.
I am concerned about the increase
JWS13
in
Advanced Prostate Cancer
5 months ago
Testosterone volatility
My testosterone was measured @ 490 in 2014 when I was DX with PCa Gleason 6, it was measured again in 2016 at 463. It was not measured again until after I started on ADT and it has been >7 ever since. Is there a way for me to extrapolate what it would have been in 2021 when I was DX with Gleason
My testosterone was measured @ 490 in 2014 when I was DX with PCa Gleason 6, it was measured again in 2016 at 463. It was not measured again until after I started on ADT and it has been >7 ever since. Is there a way for me to extrapolate what it would have been in 2021 when I was DX with Gleason
Scout4answers
in
Prostate Cancer Network
5 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Advanced Prostate Cancer
5 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Prostate Cancer Network
5 months ago
Hypo, Hashi's, Menopause & Testosterone
My last sex hormone blood test showed my testosterone at [u]
1.91!
[/u]
(range of 0.10-1.42) This concerns my Endo doc who has been amazing treating my thyroid issues, but has now informed me that AFTER
age 60
you shouldn't BEGIN hrt. 😪 So, that's out of the question for me since
My last sex hormone blood test showed my testosterone at [u]
1.91!
[/u]
(range of 0.10-1.42) This concerns my Endo doc who has been amazing treating my thyroid issues, but has now informed me that AFTER
age 60
you shouldn't BEGIN hrt. 😪 So, that's out of the question for me since
wavedancers
in
Thyroid UK
5 months ago
Low testosterone is associated with extremely poor survival metrics, post-ADT.
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
janebob99
in
Prostate Cancer Network
5 months ago
Low Testosterone reduces Survival by a huge amount.
This plot compares prostate cancer specific mortality probability versus time for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable intermediate risk who underwent
This plot compares prostate cancer specific mortality probability versus time for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable intermediate risk who underwent
janebob99
in
Prostate Cancer Network
5 months ago
Doubling Times and PSA acceleration - Part II
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
janebob99
in
Prostate Cancer Network
5 months ago
PSA levels will increase over time, depending on the level of testosterone - Part I
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
janebob99
in
Prostate Cancer Network
5 months ago
Medichecks help!
So I’m no not the best with maths and need help as Google’s confusing me even more! I ordered bloods through medichecks for DHEAs and testosterone as recommended on here and in the book “it starts with the egg” I waited a week and my lab results are in… Great- or so I thought! Medichecks have
So I’m no not the best with maths and need help as Google’s confusing me even more! I ordered bloods through medichecks for DHEAs and testosterone as recommended on here and in the book “it starts with the egg” I waited a week and my lab results are in… Great- or so I thought! Medichecks have
Eat-sleep-ivf-repeat
in
Fertility Network UK
5 months ago
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