Low-T is associated with worse Prostate Cancer Specific Mortality probability after 6 months of ADT: Part III

[janebob99]

Here are comparisons of the Prostate Cancer Specific Mortality (PCSM) probability (%) for two different testosterone levels (Low-T and Normal-T) and four different Times After PSA Failure from the Kaplan-Meier plot previously posted. (Atkins 2018).

The median testosterone for the Low-T group is T = 162 ng/dL [120-236], and I assumed an average value of 500 ng/dL for the Normal group.

The cohort is: Unfavorable Risk after RT and 6 months of ADT.

These plots show that the probability of dying from prostate cancer (after PSA failure) is significantly worse for men with Low-T. Since this data is after PSA failure, we can assume that the men in this cohort are castrate-resistant.

This plot supports the statement that after PSA failure (in castrate-resistant men) a lower level of T is associated with significantly greater (worse) probability of death due to prostate cancer.

[dhccpa]

Same question as I posted in last post.

Great work, though!

[j-o-h-n]

Thanks for the Cheer!!!

Good Luck, Good Health and Good Humor.

j-o-h-n

[Break60]

this doesn’t jibe with your comment that low T is a good think. What am I missing?

[janebob99 in reply to Break60]

This plot shows the prostate cancer mortality rate (probability) versus testosterone level for 4 different time slices. You want to have a low mortality rate (high survival rate), preferably zero mortality %.

These plots show that the probability of dying from prostate cancer (after PSA failure) is significantly worse for men with Low-T. Since this data is after PSA failure, we can assume that the men in this cohort are castrate-resistant.

In this regime of castrate-resistant, lower T is associated with worse outcomes.

The opposite is true for men who are still castrate-sensitive (which is the whole basis behind doing ADT). In this regime, low T is beneficial. In fact, getting very close to zero ( < 5 ng/dL) is hugely beneficial.

I agree that it can be confusing, though. You always have to ask "Which regime am I in...castrate-sensitive or castrate-resistant".