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Baseline PSMA-Pet scan?
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
duxlubber
in
Advanced Prostate Cancer
5 months ago
Non metastasis castrate resistant
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
Sailameme
in
Advanced Prostate Cancer
5 months ago
Tuff Nutt is back with lots of questions!
In late November, 2023, I made two trips to ER for low BP and extreme chest pain in the same week. While in the hospital the second visit, my pre ER sore throat symptoms developed into something called HPIV-3. My first evening after being discharged, I developed uncontrollable coughing. This continued
In late November, 2023, I made two trips to ER for low BP and extreme chest pain in the same week. While in the hospital the second visit, my pre ER sore throat symptoms developed into something called HPIV-3. My first evening after being discharged, I developed uncontrollable coughing. This continued
TuffNuttoCrack
in
Advanced Prostate Cancer
5 months ago
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High Testosterone Level Why?
It is nearly 2'years since I was admitted to hospital to discover I had decompensated liver disease. Now I am compensated with very good bloods, no meds, and healthy. except my testosterone level . It is constantly high around 40 nmol or approx 1135 :ng/dl .( Has been higher ) I'm 62 male and as
It is nearly 2'years since I was admitted to hospital to discover I had decompensated liver disease. Now I am compensated with very good bloods, no meds, and healthy. except my testosterone level . It is constantly high around 40 nmol or approx 1135 :ng/dl .( Has been higher ) I'm 62 male and as
Taffypaul
in
British Liver Trust
5 months ago
Revised Plot of PSA vs Testosterone: Estrogen vs Lupron ADT
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
janebob99
in
Advanced Prostate Cancer
5 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA vs Testosterone at high T levels - Linear Model
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
janebob99
in
Advanced Prostate Cancer
5 months ago
ADT response and questions for MO
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Lovecherries
in
Advanced Prostate Cancer
5 months ago
Do testosterone supplements help raise testosterone levels after use of Lupron with radiation?
trying to decide to decide between surgery and radiation w/Lupron as a treatment for prostate cancer. I’m particularly concerned with how long it takes to restore testerone levels after 6 months on Lupron. Does the use of testerone supplements help restore T levels more quickly?
trying to decide to decide between surgery and radiation w/Lupron as a treatment for prostate cancer. I’m particularly concerned with how long it takes to restore testerone levels after 6 months on Lupron. Does the use of testerone supplements help restore T levels more quickly?
Godfather2
in
Prostate Cancer Network
5 months ago
PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
5 months ago
PSA vs Testosterone Nadir for CRPC and Non-CRPC
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
janebob99
in
Advanced Prostate Cancer
5 months ago
T + Chemo?
Hi guys, This may be a dumb question but my understanding of chemo is that it is most effective when the cancer is growing rapidly. Would it be of any use to kick up the testosterone way high to get everything cooking, and then hit it hard with chemo? It's in my future of course, but I'm just curious
Hi guys, This may be a dumb question but my understanding of chemo is that it is most effective when the cancer is growing rapidly. Would it be of any use to kick up the testosterone way high to get everything cooking, and then hit it hard with chemo? It's in my future of course, but I'm just curious
Bruce66
in
Advanced Prostate Cancer
5 months ago
Mortality Probability after first PSA rise vs non-castrate testosterone levels (low vs Normal)
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA reduction after Estrogen Patch Therapy
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA reduction by Estrogen Patch (revised)
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
janebob99
in
Prostate Cancer Network
5 months ago
My story of weight loss and redemption
Hi I worked 4 jobs... I commuted.. I took energy in its most obvious and conveneient way i.e. sugar...I help bring up three kids... I thought I could postpone my weight fitness issue until I retired...I retired, the Teachers Pension messed up my pension...I spent months sitting by the phone finally
Hi I worked 4 jobs... I commuted.. I took energy in its most obvious and conveneient way i.e. sugar...I help bring up three kids... I thought I could postpone my weight fitness issue until I retired...I retired, the Teachers Pension messed up my pension...I spent months sitting by the phone finally
Iro1
2024 February
in
Weight Loss Support
5 months ago
Hashimotos - understanding latest blood test results - any advice for next steps?
Hi all, my partner (44F) has been struggling with hypothyroid / possible PCOS symptoms for ~18 months (thinning hair all over, some hirsutism and weight gain). She was diagnosed with Hashimotos in October 2022. We have been trying an approach to tackle both the thyroid issues and the hyperandrogenism
Hi all, my partner (44F) has been struggling with hypothyroid / possible PCOS symptoms for ~18 months (thinning hair all over, some hirsutism and weight gain). She was diagnosed with Hashimotos in October 2022. We have been trying an approach to tackle both the thyroid issues and the hyperandrogenism
Ehal89
in
Thyroid UK
7 months ago
PSA drop with decreasing Testosterone after Estrogen Patch Therapy
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA drops with decreasing Testosterone
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Prostate Cancer Network
5 months ago
PCa Probability versus testosterone nadir - 7
Last plot. Nice linear relationship. Lower T-nadir is better. Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372851/
Last plot. Nice linear relationship. Lower T-nadir is better. Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372851/
janebob99
in
Advanced Prostate Cancer
5 months ago
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