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Drug fails in Phase II trial for treating Parkinson's Disease - Exenatide (Byetta, Bydureon)
Evidence suggest that microglia are relevant to Parkinson's disease pathogenesis, therefore the recent clinical trial warranted exploration of trying to attenuate pathogenic microglial function. They sought to test the safety and efficacy of NLY01—a brain penetrant, pegylated, longer-lasting version
Evidence suggest that microglia are relevant to Parkinson's disease pathogenesis, therefore the recent clinical trial warranted exploration of trying to attenuate pathogenic microglial function. They sought to test the safety and efficacy of NLY01—a brain penetrant, pegylated, longer-lasting version
Baron1
in
Cure Parkinson's
9 months ago
Good vitamins and supplements
Hi, I have created a good supply of embryos on vitamins and supplements despite DOR and advanced age (43-44). I was planning to continue most of these for my transfers and bought some additional supplements that are good for transfers (such as Arginine, Carnitine, etc). Unfortunately I also have
Hi, I have created a good supply of embryos on vitamins and supplements despite DOR and advanced age (43-44). I was planning to continue most of these for my transfers and bought some additional supplements that are good for transfers (such as Arginine, Carnitine, etc). Unfortunately I also have
Lilly12255
in
Fertility Network UK
9 months ago
Pregabalin Timing ?
So, Im going from Gabapentin (4-5yrs.) to pregabalin. My usual symptoms are from 8pm to 12pm. and I would say severe and most every night.( sometime varied throughout the day but rarely) Im to take 100mg Pregabalin twice a day. But at what times? I've tried 7pm and 9pm, then 5pm and 8:30pm. Im confused
So, Im going from Gabapentin (4-5yrs.) to pregabalin. My usual symptoms are from 8pm to 12pm. and I would say severe and most every night.( sometime varied throughout the day but rarely) Im to take 100mg Pregabalin twice a day. But at what times? I've tried 7pm and 9pm, then 5pm and 8:30pm. Im confused
C82021
in
Restless Legs Syndrome
9 months ago
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A lightbulb moment
I am currently taking 10mg immediate release Shortec Oxycodone at 6pm, 10pm and again when I need to during the early hours. I manage to get broken sleep which usually equates to 4 hours, which is better than I have had in the past. This works reasonably well, however, from early afternoon my arms
I am currently taking 10mg immediate release Shortec Oxycodone at 6pm, 10pm and again when I need to during the early hours. I manage to get broken sleep which usually equates to 4 hours, which is better than I have had in the past. This works reasonably well, however, from early afternoon my arms
Mulberry100
in
Restless Legs Syndrome
9 months ago
coming off Sotalol
I had an ablation in September. I read the Drs letter they gave me when going home and it looks like they’ll be taking me off Sotalol. I had to stop this for 2 days before my ablation and it started my AFib off, so obviously I’m worried about stopping it again. I am on 80mg twice a day now. They reduced
I had an ablation in September. I read the Drs letter they gave me when going home and it looks like they’ll be taking me off Sotalol. I had to stop this for 2 days before my ablation and it started my AFib off, so obviously I’m worried about stopping it again. I am on 80mg twice a day now. They reduced
Sixtychick
in
Atrial Fibrillation Support
9 months ago
Oxycodone anxiety
After being on Tramadol for 8y and augmenting on it, my doctor switched me to a relatively low dose of 5mg oxycodone immediate release tablet. I’ve been on it for 5 months and it has worked well controlling my RLS. Also, I have taken it strictly as directed to the point of taking it at the exact time
After being on Tramadol for 8y and augmenting on it, my doctor switched me to a relatively low dose of 5mg oxycodone immediate release tablet. I’ve been on it for 5 months and it has worked well controlling my RLS. Also, I have taken it strictly as directed to the point of taking it at the exact time
Nikos64
in
Restless Legs Syndrome
9 months ago
Impaired Sensitivity to Thyroid Hormones Associated with Central Obesity in Euthyroid Type 2 Diabetes Mellitus with Overweight & Obesity
A paper of possible interest. But it could be turned round and made YOUR FAULT for having impaired sensitivity. And dislike the language where [i]high levels of TT3RI and TFQIFT3[/i] are referred to as if they are real substances. Not that they are indexes based on measurements. [i]Diabetes Metab
A paper of possible interest. But it could be turned round and made YOUR FAULT for having impaired sensitivity. And dislike the language where [i]high levels of TT3RI and TFQIFT3[/i] are referred to as if they are real substances. Not that they are indexes based on measurements. [i]Diabetes Metab
helvella
Thyroid UK
in
Thyroid UK
18 hours ago
PMR, Prednisolone and diet
I have read a bit about the effect of Prednisolone on bone density and also on blood sugar. Can anyone give me a heads up on this as I have a family history of type 2 diabetes in later life and I have osteopenia (Dexa scan every 2-3 years)
I have read a bit about the effect of Prednisolone on bone density and also on blood sugar. Can anyone give me a heads up on this as I have a family history of type 2 diabetes in later life and I have osteopenia (Dexa scan every 2-3 years)
LittleJane
in
PMRGCAuk
19 hours ago
Hydrocodone to Tramadol?
So the USA ran out of Hydrocodone 10/325 due to DEA putting limits on annual production. My last fill was 11-6-23. Luckily I had saved up 90 units for emergency (proof I'm not abusing) but that ran out yesterday. I asked my doc to prescribe tramadol hcl 50mg to get by until production resumes. Started
So the USA ran out of Hydrocodone 10/325 due to DEA putting limits on annual production. My last fill was 11-6-23. Luckily I had saved up 90 units for emergency (proof I'm not abusing) but that ran out yesterday. I asked my doc to prescribe tramadol hcl 50mg to get by until production resumes. Started
billy_in_slo
in
Restless Legs Syndrome
9 months ago
Mody type 10
Hi, I’m Rexi and I’m from Germany. Over 30 years ago, I was diagnosed with Type 1 diabetes. I spent a year without insulin and have been taking insulin since then, but only very, very few units. Since my C-peptide level is still quite high and I have no antibodies, a genetic test for MODY was done. It
Hi, I’m Rexi and I’m from Germany. Over 30 years ago, I was diagnosed with Type 1 diabetes. I spent a year without insulin and have been taking insulin since then, but only very, very few units. Since my C-peptide level is still quite high and I have no antibodies, a genetic test for MODY was done. It
Rexi99
in
Diabetes Research & Wellness Foundation
4 days ago
PREDNISONE AND DIABETES TYPE 2
My GP doesnt like prescribing prednisone high dose as I am TYPE 2. Started OZEMPIC 0.5 mg once a week a number of months ago. My BS ended up very low and stable. Started 25mg PRED few days ago, blood sugar rises from 7-8 to 15 a few hours after dinner each night. Next morning when I wake up its down
My GP doesnt like prescribing prednisone high dose as I am TYPE 2. Started OZEMPIC 0.5 mg once a week a number of months ago. My BS ended up very low and stable. Started 25mg PRED few days ago, blood sugar rises from 7-8 to 15 a few hours after dinner each night. Next morning when I wake up its down
Oztrax
in
PMRGCAuk
7 days ago
Atrial flutter patient information
Atrial flutter is a relatively common heart rhythm disturbance encountered by doctors, although not as common as Atrial Fibrillation (AF). It can affect adults of any age but is more common in older patients and is also more common in men. Please download our booklet
'Atrial flutter patient information
Atrial flutter is a relatively common heart rhythm disturbance encountered by doctors, although not as common as Atrial Fibrillation (AF). It can affect adults of any age but is more common in older patients and is also more common in men. Please download our booklet
'Atrial flutter patient information
SamAdmin
Administrator
in
Atrial Fibrillation Support
14 days ago
Statin Prescribing - UK NICE & QOF Guidance
The Quality Outcomes Framework does sometimes appear to be payment for prescribing statins, or gets described as such, but the actual wording is somewhat more nuanced than that. And it specifically recognises that not everyone should be on statins including patient saying no: [i]
or where a statin
The Quality Outcomes Framework does sometimes appear to be payment for prescribing statins, or gets described as such, but the actual wording is somewhat more nuanced than that. And it specifically recognises that not everyone should be on statins including patient saying no: [i]
or where a statin
helvella
Thyroid UK
in
Thyroid UK
26 days ago
My method weight reduce. Overweight,obesity
My method for weight reduction is for me and for other people with permanent overweight! This method change the hollow carbohydrate in another food with very low calories! Its a very good methode for weight reduce, and for a permanet same weight! The best method for a permanent weightreduction
My method for weight reduction is for me and for other people with permanent overweight! This method change the hollow carbohydrate in another food with very low calories! Its a very good methode for weight reduce, and for a permanet same weight! The best method for a permanent weightreduction
Uwe45
in
Healthy Eating
1 month ago
Has anyone tried Celadrin or Glucosamine Sulphate for Fibro?
Hi, I recently read an article about someone with fibromyalgia who said Celadrin cream really helped them with their stiff muscles. I then did some reading of my own about it and found that celadrin works best when combined with glucosamine sulphate. Has anyone tried either of these for their fibro?
Hi, I recently read an article about someone with fibromyalgia who said Celadrin cream really helped them with their stiff muscles. I then did some reading of my own about it and found that celadrin works best when combined with glucosamine sulphate. Has anyone tried either of these for their fibro?
Twin4Life
in
Fibromyalgia Action UK
1 month ago
Tips for a clean and clear blood test
Dear All, I'm asking you as I know you will have answers. I have a blood test arranged, not for Thyroid, I know those does and don'ts (thanks to HealthUnlocked). This test is to differentiate between Type 1 and Type 2 Diabetes. I can go at a time I want, would it be best first thing, lunchtime
Dear All, I'm asking you as I know you will have answers. I have a blood test arranged, not for Thyroid, I know those does and don'ts (thanks to HealthUnlocked). This test is to differentiate between Type 1 and Type 2 Diabetes. I can go at a time I want, would it be best first thing, lunchtime
rosiebones
in
Thyroid UK
1 month ago
Glucosamine Sulphate.
Hello Fybro family, I hope you are all keeping as well as you can. Does anyone take the supplement Glucosamine Sulphate? A friend thought it might help with the pain & stiffness, though can't seem to find too much information about whether it helps with fibromyralgia. I'd be grateful in hearing about
Hello Fybro family, I hope you are all keeping as well as you can. Does anyone take the supplement Glucosamine Sulphate? A friend thought it might help with the pain & stiffness, though can't seem to find too much information about whether it helps with fibromyralgia. I'd be grateful in hearing about
Dreamgreen
in
Fibromyalgia Action UK
1 month ago
Suspected Malabsorption
I have an underactive thyroid, after a few months of being diagnosed I was losing nutrients I told my doctor I thought I had malabsorption syndrome, they never said anything and they order a test for celiac but was negative, I've been supplementing with vitamins since.... But over the last 3 weeks/month
I have an underactive thyroid, after a few months of being diagnosed I was losing nutrients I told my doctor I thought I had malabsorption syndrome, they never said anything and they order a test for celiac but was negative, I've been supplementing with vitamins since.... But over the last 3 weeks/month
Jojomcc
in
Thyroid UK
1 month ago
Cholesterol readings
Hello medically-minded people Tryimg to decide whether to take statins or not. This is my latest cholesterol test readings. I knw that the total cholesterol level is high (as it tells me) but my diet is not bad (exercise level lowish though due to PMR) but are there any/enough mitigating factors? Due
Hello medically-minded people Tryimg to decide whether to take statins or not. This is my latest cholesterol test readings. I knw that the total cholesterol level is high (as it tells me) but my diet is not bad (exercise level lowish though due to PMR) but are there any/enough mitigating factors? Due
marionofnorwich
in
PMRGCAuk
1 month ago
Calprotectin level
Hi everyone I've recently been diagnosed with ulcerative colitis (sept) I have been taking mesalazine tablets since June and now I have seen a gastroenterologist (mid Nov) he has added new medication which is a pentasa enama and a prednisolone enama which I am 3 weeks into I have been asked to do another
Hi everyone I've recently been diagnosed with ulcerative colitis (sept) I have been taking mesalazine tablets since June and now I have seen a gastroenterologist (mid Nov) he has added new medication which is a pentasa enama and a prednisolone enama which I am 3 weeks into I have been asked to do another
GRIMMEY1
in
Crohn's and Colitis Support
9 months ago
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