Impaired Sensitivity to Thyroid Hormones Associated with Central Obesity in Euthyroid Type 2 Diabetes Mellitus with Overweight & Obesity

[helvella]

A paper of possible interest.

But it could be turned round and made YOUR FAULT for having impaired sensitivity.

And dislike the language where high levels of TT3RI and TFQIFT3 are referred to as if they are real substances. Not that they are indexes based on measurements.

Diabetes Metab Syndr Obes. 2024 Sep 11:17:3379-3396.

doi: 10.2147/DMSO.S472550. eCollection 2024.

Impaired Sensitivity to Thyroid Hormones is Associated with Central Obesity in Euthyroid Type 2 Diabetes Mellitus Patients with Overweight and Obesity

Fei Chen 1 2 , Rujun Chen # 3 , Jiangfeng Zhou # 1 2 , Weiyi Xu # 1 2 , Jiahui Zhou 1 4 , Xianxian Chen 1 5 , Xiaohua Gong 1 , Zimiao Chen 1

PMID: 39280173 PMCID: PMC11402367 DOI: 10.2147/DMSO.S472550

Abstract

Background: Thyroid hormone levels are associated with the distribution of body components in humans.

Objective: This study aimed to investigate the associations between thyroid hormone (TH) levels, central sensitivity to THs, and body composition in overweight and obese patients with euthyroid type 2 diabetes mellitus (T2DM).

Methods: This cross-sectional study included 1215 euthyroid T2DM patients (721 men and 494 women) aged 20-80 years. The thyroid hormone sensitivity indices included the thyroid feedback quartile-based index (TFQI), thyrotroph T3 resistance index (TT3RI), thyrotroph T4 resistance index (TT4RI), and thyroid-stimulating hormone index (TSHI). The appendicular fat ratio, trunk fat ratio, android fat ratio, gynoid fat ratio, and appendicular skeletal muscle mass (ASM) were measured via dual-energy X-ray absorptiometry.

Results: The data revealed a greater proportion of subjects with impaired central sensitivity to THs in the obese group. TFQIFT4 and TFQIFT3 levels were positively correlated with the upper limb fat ratio, lower limb fat ratio, gynoid fat ratio, and total fat ratio. TSHI was positively correlated with body mass index (BMI), upper limb fat ratio, lower limb fat ratio, trunk fat ratio, android fat ratio, gynoid fat ratio, total fat ratio, and appendicular skeletal muscle mass index (ASMI) in women. In men, TSHI was only positively correlated with upper limb fat ratio, lower limb fat ratio, and total fat ratio. Logistic regression analysis indicated that TT3RI and TFQIFT3 were independently and positively associated with central obesity and low muscle mass in overweight and obese men. No significant differences were found among the women.

Conclusion: THs central sensitivity is related to the body composition of euthyroid T2DM patients. Specifically, high levels of TT3RI and TFQIFT3 are associated with central obesity and low muscle mass in T2DM men with overweight and obesity.

Keywords: body components; euthyroid; fat ratio; muscle mass; obese; thyroid hormones central sensitivity.

Full paper open access here:

ncbi.nlm.nih.gov/pmc/articl...

DippyDame

[Jazzw]

Which came first eh, the weight gain or the diabetes?

Honestly… it’s an awful lot of research jargon and medical terminology for a “Well, doh!” conclusion, doesn’t it? But I’m pleased for the researchers that they found a conclusion they liked.