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PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong
Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Last one
Hi everyone So I’ve just finished with the zoladex injections. They were useless for me and gave me heavy periods. I’m up for trying anything. Pills patches creams drops. Anything I’ll give a go. Menopause did not stop the pain. ☹️. Crazy really as I first went to see a doctor for heavy periods in
Hi everyone So I’ve just finished with the zoladex injections. They were useless for me and gave me heavy periods. I’m up for trying anything. Pills patches creams drops. Anything I’ll give a go. Menopause did not stop the pain. ☹️. Crazy really as I first went to see a doctor for heavy periods in
Greenlady48
in
Endometriosis UK
2 years ago
Low iron levels
I have been put on Ferrous Sulphate tablets because my serum ferritin was only 11 (lower limit of normal is 15) It was picked up from a routine blood test but I have been even more fatigued than ever for some while now, had palpitations and I am naturally pale skinned. Does anyone know if this is a consequence
I have been put on Ferrous Sulphate tablets because my serum ferritin was only 11 (lower limit of normal is 15) It was picked up from a routine blood test but I have been even more fatigued than ever for some while now, had palpitations and I am naturally pale skinned. Does anyone know if this is a consequence
altywhite
in
PMRGCAuk
2 years ago
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Where to buy affordable Enzalutamide?
Just wondering if its possible to buy this drug anywhere at reasonable prices? I know I can get generic abiraterone from India which can be affordable. Only problem is my dad already has had abiraterone many years ago and I would like to add enzalutamide to radium 223 which has been proven safe and more
Just wondering if its possible to buy this drug anywhere at reasonable prices? I know I can get generic abiraterone from India which can be affordable. Only problem is my dad already has had abiraterone many years ago and I would like to add enzalutamide to radium 223 which has been proven safe and more
Howmuchisthefish
in
Advanced Prostate Cancer
2 years ago
Radium 223
I just completed radium 223 number two both times I seem to have blood in my urine. Is anyone else on this blog had the same issue. Any response gratefully accepted.
I just completed radium 223 number two both times I seem to have blood in my urine. Is anyone else on this blog had the same issue. Any response gratefully accepted.
Goldberg
in
Advanced Prostate Cancer
2 years ago
My #1 support person & me
I'm new to the form. I have mcrpc. I was on lupron injections for almost 1 year. I didn’t like the pain for 5 days after injection plus insurance only paid half the cost so I got an orchiectomy. I don’t regret that. Several months after the orchiectomy, my PSA level went up so my urologist said it’s
I'm new to the form. I have mcrpc. I was on lupron injections for almost 1 year. I didn’t like the pain for 5 days after injection plus insurance only paid half the cost so I got an orchiectomy. I don’t regret that. Several months after the orchiectomy, my PSA level went up so my urologist said it’s
Canis-Lupus53
in
Advanced Prostate Cancer
2 years ago
Decision time. Input welcome
Saw my MO yesterday. I need to make a decision by next week on how to proceed. My personal life is imploding and all I see there is having to sell my house and move to... someplace -- long story, but everything I've tried has come up short. BTW, I live by myself with no close friends and only a very
Saw my MO yesterday. I need to make a decision by next week on how to proceed. My personal life is imploding and all I see there is having to sell my house and move to... someplace -- long story, but everything I've tried has come up short. BTW, I live by myself with no close friends and only a very
Miccoman
in
Advanced Prostate Cancer
2 years ago
Anyone tried Iqoro?
I’m running out of ideas to solve my coughing caused by acid reflux. I’ve tried PPi’s over the years. Recently tried famitodine. Nothing seems to work. Gaviscon Advance helps a little. I am careful with what I eat and drink. My coughing starts after I have eaten or drunk something. Lasts about 15
I’m running out of ideas to solve my coughing caused by acid reflux. I’ve tried PPi’s over the years. Recently tried famitodine. Nothing seems to work. Gaviscon Advance helps a little. I am careful with what I eat and drink. My coughing starts after I have eaten or drunk something. Lasts about 15
Heatherfeb
in
Oesophageal & Gastric Cancer
2 years ago
Low Vitamin D/ Low iron
Hi! March hasn’t been my best month I’ve had bad panic attacks which lead me to the hospital 3 times and each time i was diagnosed with anxiety and i’ve never in my life had anxiety and panic attacks up until then and it was out of the blue. Since last may my periods would be 2/3 months long with 2 week
Hi! March hasn’t been my best month I’ve had bad panic attacks which lead me to the hospital 3 times and each time i was diagnosed with anxiety and i’ve never in my life had anxiety and panic attacks up until then and it was out of the blue. Since last may my periods would be 2/3 months long with 2 week
certifiedlovergirl17
in
Anxiety Support
2 years ago
Tramadol Tolerance
I have had severe RLS for over 10 years, was initially on dopamine agonists (until I augmented!) and been on Tramadol (100mg/day) plus Gabapentin (1200mg/day) for over 8 years. My Ferritin level is usually about 75 so I am currently trying to raise it. I tried Bisglycinate for 3 months without any improvement
I have had severe RLS for over 10 years, was initially on dopamine agonists (until I augmented!) and been on Tramadol (100mg/day) plus Gabapentin (1200mg/day) for over 8 years. My Ferritin level is usually about 75 so I am currently trying to raise it. I tried Bisglycinate for 3 months without any improvement
John_naylor
in
Restless Legs Syndrome
2 years ago
Newly Diagnosed Hypothyroidism
Hi. I’m new to this forum and joined after a recommendation from a friend who has hypothyroidism. I had a blood test in June 2021 because of extreme fatigue. TFT came back fine but ferritin level was 9. Commenced on ferrous sulphate for 3 months, bloods re-tested and ferritin was 27. Told to stay on
Hi. I’m new to this forum and joined after a recommendation from a friend who has hypothyroidism. I had a blood test in June 2021 because of extreme fatigue. TFT came back fine but ferritin level was 9. Commenced on ferrous sulphate for 3 months, bloods re-tested and ferritin was 27. Told to stay on
TraceyT30
in
Thyroid UK
2 years ago
Bowel obstruction after debulking surgery
I was all set to start chemo on Thursday after getting colonoscopy this morning. Unfortunately they found an obstruction. I had complete hysterectomy and debulking surgery 3.5 weeks ago. Getting a barium enema tomorrow to find out more where obstruction is. This is so discouraging as I just feel like
I was all set to start chemo on Thursday after getting colonoscopy this morning. Unfortunately they found an obstruction. I had complete hysterectomy and debulking surgery 3.5 weeks ago. Getting a barium enema tomorrow to find out more where obstruction is. This is so discouraging as I just feel like
Pinky-g
in
My Ovacome
2 years ago
IBS Help
I am new here and hoping for some help. Have had stomach issues for a number of years but in the last 3 years it has got a lot worse. Pain under ribs mainly left side, pain in chest and sometimes moves to upper back. Lots of burping especially after eating or drinking and some acid. Loose stools in
I am new here and hoping for some help. Have had stomach issues for a number of years but in the last 3 years it has got a lot worse. Pain under ribs mainly left side, pain in chest and sometimes moves to upper back. Lots of burping especially after eating or drinking and some acid. Loose stools in
Old-Owl
in
IBS Network
2 years ago
LU-177
Crazy how fast things change. The same day we saw Dr. Kwon we saw Jeff’s radiation oncologist that afternoon. As I wasn’t anticipating much of an update from that appointment, I posted an update prematurely. In short, Jeff’s radiation oncologist felt radium 223 was the best next treatment. Radium 223
Crazy how fast things change. The same day we saw Dr. Kwon we saw Jeff’s radiation oncologist that afternoon. As I wasn’t anticipating much of an update from that appointment, I posted an update prematurely. In short, Jeff’s radiation oncologist felt radium 223 was the best next treatment. Radium 223
Pancake_Lefse
in
Advanced Prostate Cancer
2 years ago
Iron Bisglycinate versus Liquid Ferrous Sulfate
Hello oh wise ones. I’m constantly here lurking in the back and rereading posts to take info back to my doc. My doc has very little knowledge of RLS but she is very open to all your information so I’m eternally grateful. Been trying to up my ferritin for the last year. Started at 8 and now a year later
Hello oh wise ones. I’m constantly here lurking in the back and rereading posts to take info back to my doc. My doc has very little knowledge of RLS but she is very open to all your information so I’m eternally grateful. Been trying to up my ferritin for the last year. Started at 8 and now a year later
Redeyed
in
Restless Legs Syndrome
2 years ago
COVID brain impact similar to Chronic Fatigue Syndrome
Apart from the AMN, I am generally healthy and not particularly worried about Covid. Maybe because I had my three vaccines and always wear a mask outdoors. I do, however, have one friend who [i]had Long Covid for over a yea[/i]r. And I have posted here before about various of these diseases having
Apart from the AMN, I am generally healthy and not particularly worried about Covid. Maybe because I had my three vaccines and always wear a mask outdoors. I do, however, have one friend who [i]had Long Covid for over a yea[/i]r. And I have posted here before about various of these diseases having
monkeybus
in
AMN EASIER
2 years ago
Barium Swallow Experience ?
Hello, I am due to have a barium swallow next week and getting a bit anxious about it. I have had endoscopies in the past, due to Celiac disease and Gastritis, but the last one made me feel really unwell, which is why my Doctor has recommended the Barium swallow. I have read up on some peoples experiences
Hello, I am due to have a barium swallow next week and getting a bit anxious about it. I have had endoscopies in the past, due to Celiac disease and Gastritis, but the last one made me feel really unwell, which is why my Doctor has recommended the Barium swallow. I have read up on some peoples experiences
ParkSchool5
in
Acid Reflux Support
2 years ago
Should Early Use of Chemotherapy Be Avoided in the Treatment of Metastatic Prostate Cancer?
Interesting editorial in JMA [Japan Medical Association] Journal: "The therapeutic strategy for advanced prostate cancer has dramatically changed recently. Previously, docetaxel was the only drug with evidences showing improved overall survival (OS) in metastatic castration-resistant prostate cancer
Interesting editorial in JMA [Japan Medical Association] Journal: "The therapeutic strategy for advanced prostate cancer has dramatically changed recently. Previously, docetaxel was the only drug with evidences showing improved overall survival (OS) in metastatic castration-resistant prostate cancer
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Prostate pain - xtandi/Xofigo & spot radiation
Hi all, just wanted to check if anyone would have any idea as to why Dad's prostate area is sore. He went to do a few minutes on his Excercise bike last week and said the pain in his prostate area was bad, he is getting up more frequently to pee at night (no pain but dribbles) and then today she said
Hi all, just wanted to check if anyone would have any idea as to why Dad's prostate area is sore. He went to do a few minutes on his Excercise bike last week and said the pain in his prostate area was bad, he is getting up more frequently to pee at night (no pain but dribbles) and then today she said
Nickhmcg
in
Advanced Prostate Cancer
2 years ago
Advice re low thyroid levels and symptoms
Hello Some advice please as my levels have been consistently low but a Consultant actually tolf me they were at optimum range when actually free t4 and free t3 were the bottom end of normal, now the t3 is out of range and my symtoms are worsening. Another said go private and finally got one that increased
Hello Some advice please as my levels have been consistently low but a Consultant actually tolf me they were at optimum range when actually free t4 and free t3 were the bottom end of normal, now the t3 is out of range and my symtoms are worsening. Another said go private and finally got one that increased
Christy52
in
Thyroid UK
2 years ago
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