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Chemo or clinical trial?
Am scheduled for bone biopsy of met(s) from my hip tomorrow. Stopped Pluvicto after #3 due to rising PSA and progression. Hoping to get next gen. sequencing from biopsy sample and (maybe) functional testing. But, it's going to take some time to get results and I feel I can't wait. Pain has been getting
Am scheduled for bone biopsy of met(s) from my hip tomorrow. Stopped Pluvicto after #3 due to rising PSA and progression. Hoping to get next gen. sequencing from biopsy sample and (maybe) functional testing. But, it's going to take some time to get results and I feel I can't wait. Pain has been getting
rsgdmd
in
Advanced Prostate Cancer
5 months ago
Dutssteride increases PSA Doubling Time by 2X for men with PSA Failure.
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Prostate Cancer Network
5 months ago
Dutasteride increases PSA Doubling Time after PSA Recurrence
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Advanced Prostate Cancer
5 months ago
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UPDATE
UPDATE Hi folks, I havnt been very active recently - mostly because things were going slowly, but well with my PCA. Ive just had my latest bloodwork which confirms a PCA increase with a doubling time of about 6 months. This is all very standard and to be expected - I am 4.3 years out from PSA of 1000
UPDATE Hi folks, I havnt been very active recently - mostly because things were going slowly, but well with my PCA. Ive just had my latest bloodwork which confirms a PCA increase with a doubling time of about 6 months. This is all very standard and to be expected - I am 4.3 years out from PSA of 1000
Stoneartist
in
Advanced Prostate Cancer
5 months ago
High PSA upon diagnosis, treatment , and outcome
Hello, Diagnosed 9 months ago with Gleason 7 unfavorable… 2 4+3 ,2 3+4, and 1 3+3 ..on one side only ..I guess my high PSA score made it unfavorable , PSA 18. As a result had aggressive tri modality treatment .. brachytherapy seeds, 15 linac radiation sessions, and 9 months o ADT ..just stopped
Hello, Diagnosed 9 months ago with Gleason 7 unfavorable… 2 4+3 ,2 3+4, and 1 3+3 ..on one side only ..I guess my high PSA score made it unfavorable , PSA 18. As a result had aggressive tri modality treatment .. brachytherapy seeds, 15 linac radiation sessions, and 9 months o ADT ..just stopped
Yokohama2023
in
Prostate Cancer Network
5 months ago
copper chelation is not something from the past: phase 2 trial gives hope!
in heavily pre treated mCRPC Although the last participants in cohort 3 only completed dosing in January 2024, 60% of participants across all cohorts so far showed reductions in prostate-specific antigen (PSA) levels of greater than 35% from a single dose of Cu-67 SAR-bisPSMA. Twenty-seven percent of
in heavily pre treated mCRPC Although the last participants in cohort 3 only completed dosing in January 2024, 60% of participants across all cohorts so far showed reductions in prostate-specific antigen (PSA) levels of greater than 35% from a single dose of Cu-67 SAR-bisPSMA. Twenty-seven percent of
Maxone73
in
Advanced Prostate Cancer
5 months ago
First MO visit
Prostectomy in 2017 and radiation in 2020 with no further treatment. PSMA test in November 2023 was negative with PSA of 0.14 at that time. My PSA has now increased to 0.34. I have my first visit with an MO in a couple weeks. Any suggestions or hints as to what to expect for treatments following
Prostectomy in 2017 and radiation in 2020 with no further treatment. PSMA test in November 2023 was negative with PSA of 0.14 at that time. My PSA has now increased to 0.34. I have my first visit with an MO in a couple weeks. Any suggestions or hints as to what to expect for treatments following
RedBird713
in
Advanced Prostate Cancer
5 months ago
PSA monitoring
Dad had his 5 years appointment this week and he had surgical removal in 2018 and it was only 0.08 post surgery ( 4+3) and had 37 rounds of radiation and was undetectable for 2 years plus 6 mo the of Lupton. Since 2021, it has fluctuated from 0.05, 0.07, 0.09, 0.07, 0.12, 0.11, 0.09, 0.12 without any
Dad had his 5 years appointment this week and he had surgical removal in 2018 and it was only 0.08 post surgery ( 4+3) and had 37 rounds of radiation and was undetectable for 2 years plus 6 mo the of Lupton. Since 2021, it has fluctuated from 0.05, 0.07, 0.09, 0.07, 0.12, 0.11, 0.09, 0.12 without any
k538
in
Prostate Cancer Network
5 months ago
Saxon clinical trial
Hello all, I was recently enrolled in the Saxon clinical trial combining Xofigo with SBRT. Is anyone else in that trial? Diagnosed with prostate Cancer July 2014, Gleason 7 (4+3) in 6 of 12 . After Radiation treatments my PSA was undetectable until July 2019. It rose to 3.9 in January 2020
Hello all, I was recently enrolled in the Saxon clinical trial combining Xofigo with SBRT. Is anyone else in that trial? Diagnosed with prostate Cancer July 2014, Gleason 7 (4+3) in 6 of 12 . After Radiation treatments my PSA was undetectable until July 2019. It rose to 3.9 in January 2020
58Willys
in
Advanced Prostate Cancer
5 months ago
Radiation after Docetaxel
My dad finished chemo Docetaxel in November 2023. In December his PSA was .61. In February it jumped to 2.3. He went for a PET scan. He went back to the doctor today his PSA jumped to 6. The scan showed that many of the metastasis in his bones shrunk are almost gone. There is one spot in his back that
My dad finished chemo Docetaxel in November 2023. In December his PSA was .61. In February it jumped to 2.3. He went for a PET scan. He went back to the doctor today his PSA jumped to 6. The scan showed that many of the metastasis in his bones shrunk are almost gone. There is one spot in his back that
Jshaw916
in
Advanced Prostate Cancer
5 months ago
my prostate cancer
Diagnosed in November 2022. Favorable intermediate with Gleason 6 & Gleason 7 (3+4), with 4 less than 5%, and low Decipher score. On AS. 13 months later, one year MRI showed “concerning” images, with irregular capsule (visible), and extra capsular extension probable (interpretation from radiologist).
Diagnosed in November 2022. Favorable intermediate with Gleason 6 & Gleason 7 (3+4), with 4 less than 5%, and low Decipher score. On AS. 13 months later, one year MRI showed “concerning” images, with irregular capsule (visible), and extra capsular extension probable (interpretation from radiologist).
woolcotton
in
Prostate Cancer Network
5 months ago
post radiation. Currently on ADT. PSA slight increase ?
Hey all, My father who started at 226PSA has finished radiation treatment about a year ago.: and remains on ADT. his PSA was sitting 0.03 but has jumped to 0.08. Is this any cause for concern? I took it as a positive as it sounds extremely low but now second guessing ..
Hey all, My father who started at 226PSA has finished radiation treatment about a year ago.: and remains on ADT. his PSA was sitting 0.03 but has jumped to 0.08. Is this any cause for concern? I took it as a positive as it sounds extremely low but now second guessing ..
FormulaRob
in
Advanced Prostate Cancer
5 months ago
2Nd Biopsy in 3+ years of Bone Met
Greetings All, A question about biopsies: Upon PC-stage 4 diagnosis per discovery of pc lesions causing spinal compression in 2020, my husband had a biopsy taken during his back surgery-which showed his already metastatic pc not to be an inherited condition. He went on to radiation of the spinal
Greetings All, A question about biopsies: Upon PC-stage 4 diagnosis per discovery of pc lesions causing spinal compression in 2020, my husband had a biopsy taken during his back surgery-which showed his already metastatic pc not to be an inherited condition. He went on to radiation of the spinal
Lavender22
in
Advanced Prostate Cancer
5 months ago
Just finished my second Pluvicto round.
After the first round my PSA went down a couple of pts. After the second round it went up about 25 pts. Have not done any scan and I would rather wait until after the third round in mid April. I see no problem with this. Increase PSA can be the result of dying cancer cells, right SUV numbers in the 20s
After the first round my PSA went down a couple of pts. After the second round it went up about 25 pts. Have not done any scan and I would rather wait until after the third round in mid April. I see no problem with this. Increase PSA can be the result of dying cancer cells, right SUV numbers in the 20s
Parscore
in
Advanced Prostate Cancer
5 months ago
PSA and Eligard and bicalutamide
My PSA keep rising. Today, PSA went up to 1.1 (Today-03/13/24) from 0.37 (January). Doctor told me to take another Eljgard injection next week. This is the 2nd time. Doctor asked me to stop taking bicalutamide and dutasteride, as they appear not to be effective any longer. He said I solely rely
My PSA keep rising. Today, PSA went up to 1.1 (Today-03/13/24) from 0.37 (January). Doctor told me to take another Eljgard injection next week. This is the 2nd time. Doctor asked me to stop taking bicalutamide and dutasteride, as they appear not to be effective any longer. He said I solely rely
Domas
in
Advanced Prostate Cancer
5 months ago
Is there hope despite the pain? Is Cabometyx worth it?
My 63 year old husband LD stopped Cabo (Cabometyx) when we had Covid (because we took Paxlovid). Now he doesn't want to start up again because of side effects we believe are caused by the Cabo: jaw pain and numbness, body aches, tingling in extremities, pain in the shoulder joint emanating down his arm
My 63 year old husband LD stopped Cabo (Cabometyx) when we had Covid (because we took Paxlovid). Now he doesn't want to start up again because of side effects we believe are caused by the Cabo: jaw pain and numbness, body aches, tingling in extremities, pain in the shoulder joint emanating down his arm
Chris_Ali
in
Advanced Prostate Cancer
5 months ago
Persistent PSA
3/23 Prostatectomy PSA pre-op 4.8 Gleason 4+4, epe: present, lymphnodes removed and clear 4/23. PSA: 0.21 7/23 PSA: 0.22 8/23. PSA: 0.32 9/23 39 rounds of IMRT, ending 11/23 1/24. PSA: 0.32 3/24 PSA: 0.39 PSMA PET scan shows no evidence of recurrence or metastatic disease
3/23 Prostatectomy PSA pre-op 4.8 Gleason 4+4, epe: present, lymphnodes removed and clear 4/23. PSA: 0.21 7/23 PSA: 0.22 8/23. PSA: 0.32 9/23 39 rounds of IMRT, ending 11/23 1/24. PSA: 0.32 3/24 PSA: 0.39 PSMA PET scan shows no evidence of recurrence or metastatic disease
Nonno
in
Prostate Cancer Network
5 months ago
PSA REACHES 5,125 !!
Diagnosed seven years ago with metastatic prostate cancer (PSA 1,666). Got down to 0.9 with hormone (eligard) shots. PSA increased, even with eligard. Recently completed my fourth of five Pluvicto infusion treatments (last due in one week). Currently, my PSA is at 5,125. Looking for similar
Diagnosed seven years ago with metastatic prostate cancer (PSA 1,666). Got down to 0.9 with hormone (eligard) shots. PSA increased, even with eligard. Recently completed my fourth of five Pluvicto infusion treatments (last due in one week). Currently, my PSA is at 5,125. Looking for similar
fsiefert
in
Advanced Prostate Cancer
5 months ago
Can’t Locate Metastasis!
My husband’s PSA is 17+ (His journey is in bio) 2 PSMA scans since Oct yet PSA continues to climb. 3 weeks ago Had CT scan with Contrast. Enlarged lymph appeared in para aortic Abdomen area. We have met with 3 Radiation Oncologist. All 3 have differing opinions. Dr. Julian Hong at UCSF and his
My husband’s PSA is 17+ (His journey is in bio) 2 PSMA scans since Oct yet PSA continues to climb. 3 weeks ago Had CT scan with Contrast. Enlarged lymph appeared in para aortic Abdomen area. We have met with 3 Radiation Oncologist. All 3 have differing opinions. Dr. Julian Hong at UCSF and his
JolleySprings
in
Advanced Prostate Cancer
5 months ago
Am I ready for the PSA test during SBRT?
Most of the lesions show no increased activity. PSA before treatment was : 14.45 Treatment has already been done for the following two lesions. Completion date is
02/23/24
1x0.7 cm active lesion is noted involving the body of T5. 1.5 x 1. cm active lesion is noted involving the left
Most of the lesions show no increased activity. PSA before treatment was : 14.45 Treatment has already been done for the following two lesions. Completion date is
02/23/24
1x0.7 cm active lesion is noted involving the body of T5. 1.5 x 1. cm active lesion is noted involving the left
God_Loves_Me
in
Advanced Prostate Cancer
5 months ago
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