Experiences with

Antagon

OK....currently metachronous oligometastatic prostate cancer diagnosed this past Fall (2024). I had SBRT (MR-Linac)to the 2 positive iliac lymph nodes in early March and I am on 3 month shots of Erleada (started Mid January) and daily 2000mg of Abiraterone (Started Mid February). PSA at start of treatment

I was initially diagnosed with prostate cancer un 2021 and treated with 23 radiation treatments and radioactive beads. In April of 2024 my Psa started to rise significantly and subsequent imaging showed I had stage 4 cancer that had spread to my lymph nodes. I was put on leuprolide inJune of 2024 and

I was a Glason 8 with PSA 5.2 and had surgery to remove my prostate in 2018. My PSA has always been <0.02 since surgery and for past 2 years I’ve gotten my PSA tested annually. Last week I had my annual PSA test and my PSA was 0.03. Always get tested at same lab on same type of machine. Should

Completed 5 months of Taxotere 1/10/25 and stopped Orgovyx and Prednisone (iADT) on 1/23. PSA dropped from 15.5 to 0.07 on 2/20 but rose to 0.17 on 3/20. Don't like the doubling time. MO appt is 4/27 following 4/20 blood test. Assuming continued PSA rise I expect to be back on ADT and also getting a

I will be on on my third cycle next Monday. Bloodtest was very good, but PSA is still rising. From 4.29 from 2 months ago, now 5.50. Is it to early to expect if it's working? I'm very worried, even if I don't have any symptoms from my stage 4 mcrPC.

I've been on Orgovyx + Abi + 5mg Prednisone now for 3 months. I've had to hound my doc for an A1C and lipid profile, since these are known to affect them. My A1c has moved from the upper range of normal to well within diabetes. It was 5.5 and is now 6.7, ouch. That 5mg of prenisone is like eating

I am writing this to see if anyone has followed a similar path and can offer impressions of side effects for Erleada vs Abiriterone. Diagnosed stage 4 July 2022. Gleason 3+4. Started Abiraterone/Pred, Lupron, Zometa in September, so have been on it 2.5yrs. The lowest my PSA got was 0.14 in January

I thought that Rad-140/150 was safer than Ostarine or Ligandrol. The majority of the evidence now points me to Ostarine being the safest. Risk Comparison Table Parameter Ostarine Ligandrol RAD-140 Winner AR Agonism Partial Full Full Ostarine Prostate AR Activation Low Moderate High Ostarine Hepatotoxicity

My husband has been advised to have open heart surgery, for valve replacement and aortic root aneurysm graft. It is recommended to be done within the next three months. Though he has a growing aneurysm the surgeons were mostly concerned about the severe aortic valve regurgitation. The longer the valve

Hello all, While still being in the midst of a full diagnosis this forum had helped me a lot so far. My dad is as we speak getting his PET scan to see if and how far his PC had spread. It all started in Feb when he did a blood test after having peeing problems for quite some time. His PSA came back

recently started both Orgo and Xtandi for stage 4 Had previous HD brachy and EBRT of prostate which went well had cat and bone scans after that showed nothing except 4 bone mets 2 in spine and 2 in lower spin and hip These probably escaped prior to my above treatments as the treated area looks

​A recent Phase I clinical trial has revealed that FOR46, an experimental antibody-drug conjugate targeting the CD46 protein, demonstrates promising efficacy in treating metastatic castration-resistant prostate cancer (mCRPC). Among patients treated at doses of 1.2 mg/kg or higher, the median radiographic

Good evening fellow warriors and members of this f’n club none of us signed up for. I started this journey 6/2012 with Gleason 9 (5+4) and a RP, Surgical pathology showed seminal vesicle invasion, 2 positive pelvic nodes and a good luck from my surgeon. Reoccurrence 2013 brought on pelvic EBRT and short

My husband was newly diagnosed with stage 4 prostate cancer Gleason 9,his psa is 58 now and he will start cemo on Thursday he is 51 years old What is the best way to tell our children, I don't want them to live the shock I'm living Thanks

Hi all, This is my first post here. My 66 year old father was diagnosed with metastatic PCa in April 2024. Initial PSA was 35.6, Gleason 5+4. A month later, PSMA-PET showed widespread mets in the tissues surrounding his prostate, including bones and lymph nodes. He did [i]not[/i] have mets in his head

Hello, As promised, I’m opening a thread to chronicle my experience with Jevtana/Cabazitaxel. My first treatment was yesterday, 3/26/2025, and so far, I can report a mostly eventless 24 hours. Unlike Docetaxel, at least my Jevtana was preceded by a Benadryl injection, which did make me pretty tired

We are in Ontario Canada and my husband was on the wait list for the newly government funded Pluvicto., which my husband's oncologist recommended as the next treatment since all other options have been exhausted. Request was put in over 6 weeks ago and we hadn't heard anything from the hospital and

Good morning, I just thought I would introduce myself. I'm Phil, I'm 58 ad live in Gods country, otherwise known as Bonnie Scotland. I discovered I had Prostate cancer after I had a back ache. My nurse was really good, so asked if I had PC in my family. I told her that both Dads Brother and Mums brother

Strategies to Resensitize CRPC to AR-Targeted Therapies Castration-resistant prostate cancer (CRPC) often remains driven by the androgen receptor (AR) pathway despite resistance to standard AR-targeted treatments. Numerous strategies – from drugs and combinations to hormonal cycling and lifestyle changes

Since lately we have been talking about resensitizing ourselves to ARPIs and other solutions to delay more drastic interventions, I remembered about ORIC-944 (sometimes my memory suprises me, considering ADT :-P ) I have already written about this, on my blog but I think also here (surely on the other