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Use of downregulation in a cycle, anyone had problems with that?

Hi ladies, anyone with very low ovarian reserve used down regulation (Buserelin, Antagon, Ganirelix, and Orgalutran)? Any problems with the periods too messed up after that?
Hi ladies, anyone with very low ovarian reserve used down regulation (Buserelin, Antagon, Ganirelix, and Orgalutran)? Any problems with the periods too messed up after that?
BBHH1 profile image
BBHH1
in Fertility Network UK

Psa rising

Psa in 2018 diagnosed with biopsy gleason 9. Has prostate robotically removed psa went to undetectable .05 from MSK. Year later climbed to 1.7. Had psma done and "bone met " on sitting bone" Had radiation 3 times to that bone and 40 times to pelvic bed which psma showed cells.. Participated in clinical
Psa in 2018 diagnosed with biopsy gleason 9. Has prostate robotically removed psa went to undetectable .05 from MSK. Year later climbed to 1.7. Had psma done and "bone met " on sitting bone" Had radiation 3 times to that bone and 40 times to pelvic bed which psma showed cells.. Participated in clinical
Moco1 profile image
Moco1
in Advanced Prostate Cancer

Nubequa Failing?

I had a PSMA scan in late Nov 2021. A few bone mets and lymph nodes in abdominal area. I had been on just Eligard for 2 years. And before that Lupron and Casodex since 2011 with some vacation time in between and a year, 2017, in a clinical trial using estrodoil applied by applying to shoulders daily.
I had a PSMA scan in late Nov 2021. A few bone mets and lymph nodes in abdominal area. I had been on just Eligard for 2 years. And before that Lupron and Casodex since 2011 with some vacation time in between and a year, 2017, in a clinical trial using estrodoil applied by applying to shoulders daily.
Joey40 profile image
Joey40
in Advanced Prostate Cancer
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What do you make of this?

Three and 1/2 years ago, my husband was diagnosed with stage 4 metastatic prostate cancer with numerous bone mets from his hip up to his skull. He was put on Lupron right away, and his PSA has never gone over <.02. (He also had Chemo & Radiation). My understanding is that Lupron supresses testosterone
Three and 1/2 years ago, my husband was diagnosed with stage 4 metastatic prostate cancer with numerous bone mets from his hip up to his skull. He was put on Lupron right away, and his PSA has never gone over <.02. (He also had Chemo & Radiation). My understanding is that Lupron supresses testosterone
kick-prostate-cancer profile image
kick-prostate-cancer
in Advanced Prostate Cancer

Any association between rising PSA and falling T during BCR?

To recap briefly - 65YO, G9 PCa, RP in '16 followed by RT/ADT. BCR in '18...detected in pelvic LNs via PSMA clinical trial. Then RT to that region and 18 months of ADT. No treatment since that ended June '20. Undetectable PSA from Jan '19 thru Oct '21. PSA creeping up from 0.03 in Oct '21 to 0.20 in
To recap briefly - 65YO, G9 PCa, RP in '16 followed by RT/ADT. BCR in '18...detected in pelvic LNs via PSMA clinical trial. Then RT to that region and 18 months of ADT. No treatment since that ended June '20. Undetectable PSA from Jan '19 thru Oct '21. PSA creeping up from 0.03 in Oct '21 to 0.20 in
shueswim profile image
shueswim
in Advanced Prostate Cancer

Enzalutamide (Xtandi) side effect

I became hormone resistant two months ago and was perscribed enzalutamide. While it did hold my PSA down to 0.1, I found the side effects devastating. I was a 7-year veteran, having had radiation HIFU and Zoladex (quarterly), none of which prepared me for my reaction to enzalutamide. I get up in the
I became hormone resistant two months ago and was perscribed enzalutamide. While it did hold my PSA down to 0.1, I found the side effects devastating. I was a 7-year veteran, having had radiation HIFU and Zoladex (quarterly), none of which prepared me for my reaction to enzalutamide. I get up in the
CYR7 profile image
CYR7
in Advanced Prostate Cancer

CAN YOU HAVE PAIN WITH NO SWELLING OR INFLAMMATION MARKERS & RIB PAIN

Hi everyone, I have psoriatic arthritis & was wondering if you can have pain without any swelling or inflammation markers showing on blood tests? Also, the awful pain I had for 3 months last year is back with a vengeance in my left side, back & front underneath my left ribs. I had a chest xray & ct
Hi everyone, I have psoriatic arthritis & was wondering if you can have pain without any swelling or inflammation markers showing on blood tests? Also, the awful pain I had for 3 months last year is back with a vengeance in my left side, back & front underneath my left ribs. I had a chest xray & ct
Garnacha profile image
Garnacha
in NRAS

XGEVA , Dosing change?

Question. I've been receiving Xgeva injections every 4 weeks for about two years now. My MO says we're going to reduce that to every 3 months. I didn't get a clear explanation as to why. Any thoughts? Also I began Eligard every 4 months with daily Zytiga 1000 mg and prednisone 5 mg x2 daily in June
Question. I've been receiving Xgeva injections every 4 weeks for about two years now. My MO says we're going to reduce that to every 3 months. I didn't get a clear explanation as to why. Any thoughts? Also I began Eligard every 4 months with daily Zytiga 1000 mg and prednisone 5 mg x2 daily in June
TommyCarz profile image
TommyCarz
in Advanced Prostate Cancer

Looking for thoughts on next treatment after Docetaxel

Here's my background. - Living in Canada, diagnosed in 2018 with 4+4 and PSA 40. - On Zoladex since 2018 and still on - 35 sessions of radiation in 2018 and PSA dropped to <1. - PSA started rising (got to 40) in Summer 2020 and started on Zytiga -Scans showed 30+ mets to spine, ribs, pelvis but no soft
Here's my background. - Living in Canada, diagnosed in 2018 with 4+4 and PSA 40. - On Zoladex since 2018 and still on - 35 sessions of radiation in 2018 and PSA dropped to <1. - PSA started rising (got to 40) in Summer 2020 and started on Zytiga -Scans showed 30+ mets to spine, ribs, pelvis but no soft
davebliz profile image
davebliz
in Advanced Prostate Cancer

PSA now at 15 time to start a treatment but don’t know which drugs.

It is time to beat the beast once and for all. I had RP and EBRT 2015 now PSA is climbing pretty quickly. PSA Trend 05/17/2022: 15.2 04/14/2022:13.45 03/09/2022: 13.3 02/09/2022: 10.3 01/12/2022: 8.4 12/01/2021: 8.93 09/15/2021: 3.6 07/21/2021: 3.08 06/21/2021: 2.4 03/23/2021: 1.8 02/25/2021
It is time to beat the beast once and for all. I had RP and EBRT 2015 now PSA is climbing pretty quickly. PSA Trend 05/17/2022: 15.2 04/14/2022:13.45 03/09/2022: 13.3 02/09/2022: 10.3 01/12/2022: 8.4 12/01/2021: 8.93 09/15/2021: 3.6 07/21/2021: 3.08 06/21/2021: 2.4 03/23/2021: 1.8 02/25/2021
KocoPr profile image
KocoPr
in Prostate Cancer Network

Pendulum

My father takes this glucose control (he is not diabetic) for Akkeansia and asked me if he should continue. I feel confused with all the latest research on gut microbiome. Does anyone here have any input? His doctor does not answer these questions. My father also asked me if pendelum could mask his PSA
My father takes this glucose control (he is not diabetic) for Akkeansia and asked me if he should continue. I feel confused with all the latest research on gut microbiome. Does anyone here have any input? His doctor does not answer these questions. My father also asked me if pendelum could mask his PSA
TheTopBanana profile image
TheTopBanana
in Advanced Prostate Cancer

Help w/rising psa

Hi everyone, I’ve been on this site since my diagnosis in March 2020 never posted anything just took in all the information. Most of what I read is beyond my comprehension, but able to comprehend some of what I read. I’m currently on Lupron and xgeva. Copy of my most recent bone scan.RADIONUCLIDE WHOLE-BODY
Hi everyone, I’ve been on this site since my diagnosis in March 2020 never posted anything just took in all the information. Most of what I read is beyond my comprehension, but able to comprehend some of what I read. I’m currently on Lupron and xgeva. Copy of my most recent bone scan.RADIONUCLIDE WHOLE-BODY
Coachmy4 profile image
Coachmy4
in Advanced Prostate Cancer

Help w/ rising PSA.

Hi everyone, I’ve been on this site since my diagnosis in March 2020 never posted anything just took in all the information. Most of what I read is beyond my comprehension, but able to comprehend some of what I read. I’m currently on Lupron and xgeva. Copy of my most recent bone scan.RADIONUCLIDE WHOLE-BODY
Hi everyone, I’ve been on this site since my diagnosis in March 2020 never posted anything just took in all the information. Most of what I read is beyond my comprehension, but able to comprehend some of what I read. I’m currently on Lupron and xgeva. Copy of my most recent bone scan.RADIONUCLIDE WHOLE-BODY
Coachmy4 profile image
Coachmy4
in Advanced Prostate Cancer

Inconclusive lesion of rib

Hi, I have been actively reading here and other than a basic question about Drs. in my area have not posted. It is likely that I shouldn't be posting in the feed regarding advanced pca, if so please inform me of where best to ask my question. My husband who is 62 yrs old was diagnosed finally (after
Hi, I have been actively reading here and other than a basic question about Drs. in my area have not posted. It is likely that I shouldn't be posting in the feed regarding advanced pca, if so please inform me of where best to ask my question. My husband who is 62 yrs old was diagnosed finally (after
Della71 profile image
Della71
in Advanced Prostate Cancer

Rising psa

Hi guys , hope you are all doing well ! I haven’t written for a while as have needed time to process everything john is on apulutimide and zoladex and exgeva and has been doing really well . His psa is down to 0.07 so we were happy he have another pmsa scan which showed resolve in all lymph nodes barring
Hi guys , hope you are all doing well ! I haven’t written for a while as have needed time to process everything john is on apulutimide and zoladex and exgeva and has been doing really well . His psa is down to 0.07 so we were happy he have another pmsa scan which showed resolve in all lymph nodes barring
palser1 profile image
palser1
in Advanced Prostate Cancer

PSA 0.01 Undetectable at last !!!

After 8.5 months on Lupron and 6 Months on Zytiga. PSA reached undetectable levels. Been off Zytiga for 14 days and liver enzymes have fallen back into normal range. Conversation with MO tomorrow , will see how and when he wants to restart it. Life is good Next step- radiation therapy.
After 8.5 months on Lupron and 6 Months on Zytiga. PSA reached undetectable levels. Been off Zytiga for 14 days and liver enzymes have fallen back into normal range. Conversation with MO tomorrow , will see how and when he wants to restart it. Life is good Next step- radiation therapy.
Scout4answers profile image
Scout4answers
in Advanced Prostate Cancer

Does Jevtana/carboplatin cross the blood-brain barrier?

Gents, My bio says it all. Some bad luck recently. I failed what may be the hottest immunotherapy therapy trial in the world (the “BiTE protocol) but then again half the men on the trial see no benefit and the scientists don’t know why, yet. If anything I and a fellow patient feel like the immunotherapy
Gents, My bio says it all. Some bad luck recently. I failed what may be the hottest immunotherapy therapy trial in the world (the “BiTE protocol) but then again half the men on the trial see no benefit and the scientists don’t know why, yet. If anything I and a fellow patient feel like the immunotherapy
tallguy2 profile image
tallguy2
in Advanced Prostate Cancer

Worry wart

Good Morning All , I started my Eligard ( 6 month )on Dec.9 2021, Zytiga ,(250mg ) Prednisone ( 5 mg) on a low fat breakfast on Feb. 1 2022. My Testosterone is at 9ng/dl . My PSA was at 4.19 on Dec. 2021 . My primary dx was gleason 4+3 downgraded to 3+4 by John Hopkins . I had Sbrt , 5 sessions on 2016
Good Morning All , I started my Eligard ( 6 month )on Dec.9 2021, Zytiga ,(250mg ) Prednisone ( 5 mg) on a low fat breakfast on Feb. 1 2022. My Testosterone is at 9ng/dl . My PSA was at 4.19 on Dec. 2021 . My primary dx was gleason 4+3 downgraded to 3+4 by John Hopkins . I had Sbrt , 5 sessions on 2016
reconjj profile image
reconjj
in The Roy Castle Lung Cancer Foundation

Unsuccessful RP 2020. PSA rising & radiation (Radical trial) about to begin. ☘️

Hi Guys I’m on here for my husband as some of you may know. RP was july 2020. 3+4=7 psa 11.4. Age 53. No further treatment and psa post op was 0.03 Pathology report showed EPE. Fast forward 18 months to 2022 when psa began to rise- Jan 0.05, Feb 0.07, March 0.09, April 0.11 I know all the
Hi Guys I’m on here for my husband as some of you may know. RP was july 2020. 3+4=7 psa 11.4. Age 53. No further treatment and psa post op was 0.03 Pathology report showed EPE. Fast forward 18 months to 2022 when psa began to rise- Jan 0.05, Feb 0.07, March 0.09, April 0.11 I know all the
dublin1717 profile image
dublin1717
in Advanced Prostate Cancer

PSA is increasing with Docetaxel, what should we do now ?

My father is now 66 years old, back in Dec 2020 he was diagnosed with Advanced PC now his PSA rised to 6.630 ng/mL on Docetaxel, what are our options given that my father is not in USA (in Egypt) ? or how should we proceed if someone has a positive experience after Docetaxel stop working ? Here's the
My father is now 66 years old, back in Dec 2020 he was diagnosed with Advanced PC now his PSA rised to 6.630 ng/mL on Docetaxel, what are our options given that my father is not in USA (in Egypt) ? or how should we proceed if someone has a positive experience after Docetaxel stop working ? Here's the
mgaa profile image
mgaa
in Advanced Prostate Cancer
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