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Short-term tactics to keep PSA in check
Good morning fellow warriors. My docetaxel adventure was without side effects but gave an ineffective response. The cabazitaxel/carboplatin combo was effective but brutal in its attack on my immune system. Having had no treatment at all while my body tries to recover, I'm currently being considered by
Good morning fellow warriors. My docetaxel adventure was without side effects but gave an ineffective response. The cabazitaxel/carboplatin combo was effective but brutal in its attack on my immune system. Having had no treatment at all while my body tries to recover, I'm currently being considered by
CrocodileShoes
in
Advanced Prostate Cancer
1 month ago
Chemo or no/not yet?
59 years old. Metastatic/high volume. PSA hit 366 before starting Abiraterone and Degarelix. Start Lupron next week. Negative on DNA test. Will see what PSA looks like next week after a month of ADT. My question chemo, no chemo or wait on chemo? Onco and Rad Onco both seemed to have a very soft attitude
59 years old. Metastatic/high volume. PSA hit 366 before starting Abiraterone and Degarelix. Start Lupron next week. Negative on DNA test. Will see what PSA looks like next week after a month of ADT. My question chemo, no chemo or wait on chemo? Onco and Rad Onco both seemed to have a very soft attitude
4tunate1
in
Advanced Prostate Cancer
1 month ago
new PSA
my PSA rose from .04 in Jan to now .21 so it’s moving up. I assume this is still too low for a scan to determine where pc is at. I was undetected for 2 years after radiation of pelvic area.
my PSA rose from .04 in Jan to now .21 so it’s moving up. I assume this is still too low for a scan to determine where pc is at. I was undetected for 2 years after radiation of pelvic area.
Howard53545
in
Advanced Prostate Cancer
1 month ago
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PSA increasing
My Dad’s PSA started increasing 2.5 years after diagnosis. It was 0.008 in December, 0.024 at the beginning of March and 0.029 on yesterday. Please advise. Any suggestions are greatly appreciated. He is still taking Lupron, Abiraterone and Prednisone 10 mg that were started back in September of 2021.
My Dad’s PSA started increasing 2.5 years after diagnosis. It was 0.008 in December, 0.024 at the beginning of March and 0.029 on yesterday. Please advise. Any suggestions are greatly appreciated. He is still taking Lupron, Abiraterone and Prednisone 10 mg that were started back in September of 2021.
Simonapo
in
Advanced Prostate Cancer
1 month ago
Xtandi worked great
After radiation to prostate bed and to one pelvic metastasis, I was on xtandi and Lupton for three years and now have been on "vacation " for a year with PSA of 0.02 and testosterone at 4. No meds at all for last11 months!Had a heart attack in May '23 (which I attribute to covid shots) , doctors told
After radiation to prostate bed and to one pelvic metastasis, I was on xtandi and Lupton for three years and now have been on "vacation " for a year with PSA of 0.02 and testosterone at 4. No meds at all for last11 months!Had a heart attack in May '23 (which I attribute to covid shots) , doctors told
JAK2243
in
Advanced Prostate Cancer
1 month ago
6 months after radiation
I had SBRT in September and all went well. My semen was a bit brownish at first, but now has become bloody red. I went for blood work and my PSA has dropped significantly and I do not have an infection. I’m wondering what the issue could be…seems like it would have cleared by now?
I had SBRT in September and all went well. My semen was a bit brownish at first, but now has become bloody red. I went for blood work and my PSA has dropped significantly and I do not have an infection. I’m wondering what the issue could be…seems like it would have cleared by now?
NYCguy123
in
Prostate Cancer And Gay Men
1 month ago
6 months after radiation
I had SBRT in September and all went well. My semen was a bit brownish at first, but now has become bloody red. I went for blood work and my PSA has dropped significantly and I do not have an infection. I’m wondering what the issue could be…seems like it would have cleared by now?
I had SBRT in September and all went well. My semen was a bit brownish at first, but now has become bloody red. I went for blood work and my PSA has dropped significantly and I do not have an infection. I’m wondering what the issue could be…seems like it would have cleared by now?
NYCguy123
in
Prostate Cancer And Gay Men
1 month ago
PSA Bounce After Radiation Therapy
I am trying to understand PSA bounce or change in PSA levels after RT and have found two studies useful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465291/ https://www.nature.com/articles/s41391-021-00387-4 Some analysts distinguish between PSA bounce and biological recurrence, and see a possibility
I am trying to understand PSA bounce or change in PSA levels after RT and have found two studies useful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465291/ https://www.nature.com/articles/s41391-021-00387-4 Some analysts distinguish between PSA bounce and biological recurrence, and see a possibility
kainasar
in
Advanced Prostate Cancer
2 months ago
PSA on the way up again
I am getting a little concerned about a increase in my PSA, and not just the increase, but also the increase in the rate of increase. Short history. Diagnosed March 2021 by MRI and biopsy Gleason 4 + 3, Stage T3B, ISUP 3 ADT (Zoladex) started June 2021 EBRT 60Gy in 20 fractions December 2021 Last
I am getting a little concerned about a increase in my PSA, and not just the increase, but also the increase in the rate of increase. Short history. Diagnosed March 2021 by MRI and biopsy Gleason 4 + 3, Stage T3B, ISUP 3 ADT (Zoladex) started June 2021 EBRT 60Gy in 20 fractions December 2021 Last
ParrotY
in
Prostate Cancer Network
2 months ago
Update and about to start Radiation
Hi all - just a summary so far. Have been doing the triplet and recently finished the 6 sessions of chemo. Had my CT and Bone scans and then follow up with MO on Friday. All is as we expect - nothing shown in CT. Bone scan shows no new "uptake" in the mets places and nothing new. PSA at .41. I am
Hi all - just a summary so far. Have been doing the triplet and recently finished the 6 sessions of chemo. Had my CT and Bone scans and then follow up with MO on Friday. All is as we expect - nothing shown in CT. Bone scan shows no new "uptake" in the mets places and nothing new. PSA at .41. I am
Yzinger
in
Advanced Prostate Cancer
2 months ago
Dutasteride Monotherapy is effective for Newly Diagnosed PCa men not on ADT
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
janebob99
in
Prostate Cancer Network
2 months ago
Spread in two months
I am rather devastated to learn after an MRI and then a PSMA that my met in the L2, even after cyberknife six months ago has now spread to my l1 and lower. I even have a met in my femur and rib. Psa went from .6 to 8 then 10 all in a couple months. Starting Pluvicto asap but I think that is the last
I am rather devastated to learn after an MRI and then a PSMA that my met in the L2, even after cyberknife six months ago has now spread to my l1 and lower. I even have a met in my femur and rib. Psa went from .6 to 8 then 10 all in a couple months. Starting Pluvicto asap but I think that is the last
crony
in
Advanced Prostate Cancer
2 months ago
Hello everyone, breif update
I moved again and hopefully this will be the last time. So, I have had to put together a new Medical team and meet my new MO this Tuesday. My bio is pretty up to date. I'm stage 4 and have some lymph node mets and some bone mets. It's been over a year since my last scan which showed improvement from
I moved again and hopefully this will be the last time. So, I have had to put together a new Medical team and meet my new MO this Tuesday. My bio is pretty up to date. I'm stage 4 and have some lymph node mets and some bone mets. It's been over a year since my last scan which showed improvement from
Startech
in
Advanced Prostate Cancer
2 months ago
Declining red blood cells.
This Poollover, and I'm stage 4 prostrate cancer. My anemia is slowly getting worse. I'm on Orgovyx and Zytiga which brought my PSA to 0.78 from 12. Where do I go from here. In June I'll be 87. Terry
This Poollover, and I'm stage 4 prostrate cancer. My anemia is slowly getting worse. I'm on Orgovyx and Zytiga which brought my PSA to 0.78 from 12. Where do I go from here. In June I'll be 87. Terry
Poollover
in
Advanced Prostate Cancer
2 months ago
Chemo or clinical trial?
Am scheduled for bone biopsy of met(s) from my hip tomorrow. Stopped Pluvicto after #3 due to rising PSA and progression. Hoping to get next gen. sequencing from biopsy sample and (maybe) functional testing. But, it's going to take some time to get results and I feel I can't wait. Pain has been getting
Am scheduled for bone biopsy of met(s) from my hip tomorrow. Stopped Pluvicto after #3 due to rising PSA and progression. Hoping to get next gen. sequencing from biopsy sample and (maybe) functional testing. But, it's going to take some time to get results and I feel I can't wait. Pain has been getting
rsgdmd
in
Advanced Prostate Cancer
2 months ago
Dutssteride increases PSA Doubling Time by 2X for men with PSA Failure.
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Prostate Cancer Network
2 months ago
Dutasteride increases PSA Doubling Time after PSA Recurrence
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Advanced Prostate Cancer
2 months ago
UPDATE
UPDATE Hi folks, I havnt been very active recently - mostly because things were going slowly, but well with my PCA. Ive just had my latest bloodwork which confirms a PCA increase with a doubling time of about 6 months. This is all very standard and to be expected - I am 4.3 years out from PSA of 1000
UPDATE Hi folks, I havnt been very active recently - mostly because things were going slowly, but well with my PCA. Ive just had my latest bloodwork which confirms a PCA increase with a doubling time of about 6 months. This is all very standard and to be expected - I am 4.3 years out from PSA of 1000
Stoneartist
in
Advanced Prostate Cancer
2 months ago
High PSA upon diagnosis, treatment , and outcome
Hello, Diagnosed 9 months ago with Gleason 7 unfavorable… 2 4+3 ,2 3+4, and 1 3+3 ..on one side only ..I guess my high PSA score made it unfavorable , PSA 18. As a result had aggressive tri modality treatment .. brachytherapy seeds, 15 linac radiation sessions, and 9 months o ADT ..just stopped
Hello, Diagnosed 9 months ago with Gleason 7 unfavorable… 2 4+3 ,2 3+4, and 1 3+3 ..on one side only ..I guess my high PSA score made it unfavorable , PSA 18. As a result had aggressive tri modality treatment .. brachytherapy seeds, 15 linac radiation sessions, and 9 months o ADT ..just stopped
Yokohama2023
in
Prostate Cancer Network
2 months ago
copper chelation is not something from the past: phase 2 trial gives hope!
in heavily pre treated mCRPC Although the last participants in cohort 3 only completed dosing in January 2024, 60% of participants across all cohorts so far showed reductions in prostate-specific antigen (PSA) levels of greater than 35% from a single dose of Cu-67 SAR-bisPSMA. Twenty-seven percent of
in heavily pre treated mCRPC Although the last participants in cohort 3 only completed dosing in January 2024, 60% of participants across all cohorts so far showed reductions in prostate-specific antigen (PSA) levels of greater than 35% from a single dose of Cu-67 SAR-bisPSMA. Twenty-seven percent of
Maxone73
in
Advanced Prostate Cancer
2 months ago
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