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PSA suppression
My PSA lows tend to be around 3.3, and it occurs to me that some might think it odd that I don't drive it lower. I think it is very common for men on ADT to draw too much comfort from a significant PSA reduction, if not a near-zero PSA. I have witnessed men misinterpret a dramatic drop in PSA as
My PSA lows tend to be around 3.3, and it occurs to me that some might think it odd that I don't drive it lower. I think it is very common for men on ADT to draw too much comfort from a significant PSA reduction, if not a near-zero PSA. I have witnessed men misinterpret a dramatic drop in PSA as
pca2004
in
Fight Prostate Cancer
4 months ago
Questions
I saw my PSA suddenly rise to 3.67 in January 2023. My PMD was not overly concerned as it was under 4. His plan was to repeat it in 6 months. I will also not I was on Tamsulosin and Finasteride for some time at that point for urinary frequency. That started several years before (at that time I was
I saw my PSA suddenly rise to 3.67 in January 2023. My PMD was not overly concerned as it was under 4. His plan was to repeat it in 6 months. I will also not I was on Tamsulosin and Finasteride for some time at that point for urinary frequency. That started several years before (at that time I was
Cleantop
in
Advanced Prostate Cancer
4 months ago
Update On Eclipse Trial-another failure. Has LU-177 worked for anyone?
In 2010 at the age of 59, I had Da Vinci surgery with a Gleason 4+5=9 and PSA of 9. Post surgical biopsy showed all margins clear with no seminal vesicle involvement and Gleason post-op score was changed to a 4+3=7. Subsequent PSA was non-detectable as tested every three months for the first two years
In 2010 at the age of 59, I had Da Vinci surgery with a Gleason 4+5=9 and PSA of 9. Post surgical biopsy showed all margins clear with no seminal vesicle involvement and Gleason post-op score was changed to a 4+3=7. Subsequent PSA was non-detectable as tested every three months for the first two years
SViking
in
Advanced Prostate Cancer
4 months ago
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ADT SE’s
I had a 6 month Lupron shot in April last year. I experienced all the typical SE the worst being the hot flashes at night. I am following the Ssport protocol for a biological reoccurrence. Basically a 6 month adt with 39 radiation treatments last year. Current labs show undetectable PSA with a slow
I had a 6 month Lupron shot in April last year. I experienced all the typical SE the worst being the hot flashes at night. I am following the Ssport protocol for a biological reoccurrence. Basically a 6 month adt with 39 radiation treatments last year. Current labs show undetectable PSA with a slow
plato123
in
Advanced Prostate Cancer
4 months ago
Recent PSA test result no longer “undetectable.” What’s next?
After 5+ years of measuring “undetectable” with my PSA results I recently measured 0.24 NG/ML which I’m assuming my PCA is becoming active again. I see my oncologist on Monday, 8 Jan for a follow-up appt. Can anyone share with me what the likely next course of action will be?
After 5+ years of measuring “undetectable” with my PSA results I recently measured 0.24 NG/ML which I’m assuming my PCA is becoming active again. I see my oncologist on Monday, 8 Jan for a follow-up appt. Can anyone share with me what the likely next course of action will be?
Woodman33
in
Advanced Prostate Cancer
4 months ago
Rising PSA … Clear PSMA SCAN
My husband sees Dr. Rahul Aggarwal at UCSF. I’m surprised by his treatment plan. hubby has been on Lupron & NUBEQA since April. At first it brought PSA down but now it is up to 6.5 His last PSMA SCAN was in October when PSA was 4.3 Next PSMA scan is mid January. Aggarwal says PSA # is no longer of
My husband sees Dr. Rahul Aggarwal at UCSF. I’m surprised by his treatment plan. hubby has been on Lupron & NUBEQA since April. At first it brought PSA down but now it is up to 6.5 His last PSMA SCAN was in October when PSA was 4.3 Next PSMA scan is mid January. Aggarwal says PSA # is no longer of
JolleySprings
in
Advanced Prostate Cancer
4 months ago
Happy New Year and Update
Update: I took what I hope will be my last Lupron shot which will work until March 5 /24. I will have had 31 months of Lupron with mostly undetectable PSA. I will have had 29 months of Abiraterone at that point. Had IMRT radiation 24 months ago Both my MO and RO are interested in whether they have
Update: I took what I hope will be my last Lupron shot which will work until March 5 /24. I will have had 31 months of Lupron with mostly undetectable PSA. I will have had 29 months of Abiraterone at that point. Had IMRT radiation 24 months ago Both my MO and RO are interested in whether they have
Scout4answers
in
Advanced Prostate Cancer
4 months ago
PSMA PET Scan????
I'm 4-3/4 years on ADT, MO has ordered NO Scans for 2 years even though I've complained of returning bone pain , groin pain, pain in ribs and spine, as well as thigh and pelvic pain. Also pre treatment cough has returned, (was diagnosed with lung mets as well as bone and lymph node).No scans have been
I'm 4-3/4 years on ADT, MO has ordered NO Scans for 2 years even though I've complained of returning bone pain , groin pain, pain in ribs and spine, as well as thigh and pelvic pain. Also pre treatment cough has returned, (was diagnosed with lung mets as well as bone and lymph node).No scans have been
TommyCarz2
in
Advanced Prostate Cancer
4 months ago
What’s after Lu-177 in Vancouver, BC?
Hi there, I’m located in Vancouver, BC 🇨🇦. My dad is on a clinical trial and after over a decade with this disease he has failed Zytiga, Xtandi, docetaxel, and is now on his 4/6 Lu-177 infusion. He’s castration-resistant and metastatic. PSA decreased considerably after the first Lu-177 infusion but
Hi there, I’m located in Vancouver, BC 🇨🇦. My dad is on a clinical trial and after over a decade with this disease he has failed Zytiga, Xtandi, docetaxel, and is now on his 4/6 Lu-177 infusion. He’s castration-resistant and metastatic. PSA decreased considerably after the first Lu-177 infusion but
PHnerd
in
Advanced Prostate Cancer
4 months ago
Rising PSA 1 year after RALP
I've been getting ultra sensitive PSA tests every three months. These are the last three scores: 0.015 0.017 0.026 (First PSA test after surgery was <0.1) I am worried. Frightened, actually. Margins were not clear on my surgical biopsy, though gleason was only 3+3. Two biopsies prior
I've been getting ultra sensitive PSA tests every three months. These are the last three scores: 0.015 0.017 0.026 (First PSA test after surgery was <0.1) I am worried. Frightened, actually. Margins were not clear on my surgical biopsy, though gleason was only 3+3. Two biopsies prior
SmasherOfAjumma
in
Prostate Cancer Network
4 months ago
metastatic prostate cancer
my dad has castrate resistant metastatic pc in bones- currently his psa is going up but his scans have been stable- he gets them Every three months- after Zytiga and xtandi are there still many treatments available- the scans were stable for over a year and he gets them Every three Months-
my dad has castrate resistant metastatic pc in bones- currently his psa is going up but his scans have been stable- he gets them Every three months- after Zytiga and xtandi are there still many treatments available- the scans were stable for over a year and he gets them Every three Months-
Chris52981
in
Advanced Prostate Cancer
4 months ago
PSA Bounce
Hello and happy New year distinguished gentlemen. I was wondering if I may please get your input on my latest PSA which bounced from 1.2 to 1.6. Why did this happen and is this something I should be concerned about? Thanks so much. Regards.
Hello and happy New year distinguished gentlemen. I was wondering if I may please get your input on my latest PSA which bounced from 1.2 to 1.6. Why did this happen and is this something I should be concerned about? Thanks so much. Regards.
caysary
in
Advanced Prostate Cancer
4 months ago
Zytiga
I've now added Zytiga-1000mg about 3 weeks ago and it has brought my PSA down to .98 from 1.8 with only Orgovyx. Is there anything I can do to bring it down still lower, ideally to an undetected level? Poolover PS I'm 86, stage 4, Gleason9.
I've now added Zytiga-1000mg about 3 weeks ago and it has brought my PSA down to .98 from 1.8 with only Orgovyx. Is there anything I can do to bring it down still lower, ideally to an undetected level? Poolover PS I'm 86, stage 4, Gleason9.
Poollover
in
Advanced Prostate Cancer
4 months ago
PSA after radiation and Hormone therapy prognosis
https://meetings.asco.org/abstracts-presentations/218387 I have be searching for some data on the impact of radiation and short term hormone therapy on Intermediate cancer. If anyone else has some additional data or experiences please post Background. I finishing up 25 doses of radiation to the
https://meetings.asco.org/abstracts-presentations/218387 I have be searching for some data on the impact of radiation and short term hormone therapy on Intermediate cancer. If anyone else has some additional data or experiences please post Background. I finishing up 25 doses of radiation to the
Mgtd
in
Prostate Cancer Network
4 months ago
Dutasteride and PSA dropping
I started taking dustasteride about 1 month ago because of high DHT and my PSA dropped from 10 to 5.5. I've read that you are supposed to double the PSA to get an "equivalent" non-dutasteride level of 11. Does anyone understand why we are supposed to double the PSA value when taking dutasteride?
I started taking dustasteride about 1 month ago because of high DHT and my PSA dropped from 10 to 5.5. I've read that you are supposed to double the PSA to get an "equivalent" non-dutasteride level of 11. Does anyone understand why we are supposed to double the PSA value when taking dutasteride?
janebob99
in
Prostate Cancer Network
4 months ago
PSA dropping and % free ratio rising - why?
OK, so as you can see from my Bio, I live in Australia and was due to start my HT this month. However, on Dec 5th, we decided to do another PSA test and surprisingly it had dropped from 8.1 in July to 4.9, so I thought maybe we should get another MRI to see what is going on. I had the MRI only a few
OK, so as you can see from my Bio, I live in Australia and was due to start my HT this month. However, on Dec 5th, we decided to do another PSA test and surprisingly it had dropped from 8.1 in July to 4.9, so I thought maybe we should get another MRI to see what is going on. I had the MRI only a few
Mike58
in
Prostate Cancer Network
4 months ago
Darolutamide failing after 2 years. Any success if I switch to Xandi or Zytiga or do I need to move to Pluvicto.
Dx 2018. PSA 16. Been on Orgovyx. Started Second line (Darolutamide) two years ago when PSA started to rise. PSA rose over the [u]last 5 months[/u] from 0.021 (August) to 0.48 I had a few bone mets and several lymph nodes when dx. Trying to find other treatments since I'm running out of Standard
Dx 2018. PSA 16. Been on Orgovyx. Started Second line (Darolutamide) two years ago when PSA started to rise. PSA rose over the [u]last 5 months[/u] from 0.021 (August) to 0.48 I had a few bone mets and several lymph nodes when dx. Trying to find other treatments since I'm running out of Standard
Longterm101
in
Advanced Prostate Cancer
4 months ago
Overall Survival With [177]Lu-PSMA-617 vs Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
Magnus1964
in
Advanced Prostate Cancer
4 months ago
"Two Invitae CHEK2 variants of "unknown consequence""
Hello - My Hopkins MO says this genetics test indicates a weakness (CHEK2 is one of the 4 or 5 PCa related variants) he thinks this could have contributed to my premature, two year BCR after RP, so he will likely prescribe chemo sooner than later though PSA will be the prime indicator. Further he suggested
Hello - My Hopkins MO says this genetics test indicates a weakness (CHEK2 is one of the 4 or 5 PCa related variants) he thinks this could have contributed to my premature, two year BCR after RP, so he will likely prescribe chemo sooner than later though PSA will be the prime indicator. Further he suggested
jackwfrench
in
Advanced Prostate Cancer
4 months ago
Criteria for "my ADT has stopped working and we have to move to another"
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
jackwfrench
in
Advanced Prostate Cancer
4 months ago
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