copper chelation is not something from the past: phase 2 trial gives hope!

[Maxone73]

in heavily pre treated mCRPC

Although the last participants in cohort 3 only completed dosing in January 2024, 60% of participants across all cohorts so far showed reductions in prostate-specific antigen (PSA) levels of greater than 35% from a single dose of Cu-67 SAR-bisPSMA. Twenty-seven percent of participants showed reductions in PSA levels of greater than 80%," the company said.

auntminnie.com/clinical-new...

[GP24]

Clarity Pharmaceuticals replaces Lutetium-177 with copper for radiating the tumor cells. Pluvicto with copper.

[Maxone73 in reply to GP24]

Yep

[spencoid2 in reply to GP24]

Are you saying that Pluvicto will use Cu64 instead of Lu 177? If being treated with Pluvicto now are they going to change? I read about the trial but nothing about using it outside of trials.

[GP24 in reply to spencoid2]

I tried to provide a simple explanation. Clarity Pharmaceuticals is developing a competing therapy to Pluvicto from Novartis which uses Copper instead of Lutetium-177.

[Maxone73 in reply to spencoid2]

Lately there has been a shift from Lu 177 to actinium and also copper as they seem to have a better profile...we will see

[Tall_Allen]

That's not just a chelated copper, which is toxic and dangerous, it is a radiopharmaceutical. Copper was tried and failed in combination with disulfiram.

onlinelibrary.wiley.com/doi...

Be careful!

[Maxone73 in reply to Tall_Allen]

Yes I meant as mechanism, not suggesting a supplementation 😀

[ARIES29]

Hmm, so is the 2mg of copper every day as supplement dangerous? No way would it be mixed with Disulfirum.

[Maxone73 in reply to ARIES29]

From my point of view (I read a lot about the subject but I am not a MD or an oncologist), when you have no data about the use of some supplement in relation to a specific kind of cancer you must be cautious because what is good for cancer A may not be useful for cancer B, not only, sometimes what is good for cancer A at stage 1 is not good for cancer A at stage 4 (for example: creatine has mixed studies about this, B12 as well and so on)...and 2 mg of copper daily is A LOT compared to the standard recommendation (cocoa powder, which is a good source of copper, has got 3.5-4 mg per 100 grams...so you'd be eating the equivalent of 50g of pure cocoa powder per day), consider that the suggested daily dose of copper for an adult male is around 900 mcg (so we talk about a bit less than a milligram)

This said, sometimes I think one should take the risk, I would not do it daily as copper as most minerals tends to accumulate, but I would maybe do a few days at 2mg then ensure that my dietary intake is around 1 mg per day, meanwhile keep an eye on the evolution of the studies (and about that nutraceutical they will be selling in India)

[ARIES29]

Thank you Maxone73, I like dark chocolate anyway which should have at least 50g of cocoa. I read that copper intake of 2mg day or every second or third day should increase red blood cells & brake up any cancer in the blood.

[garyjp9 in reply to ARIES29]

Do you have a reference for this, or do you remember where you read it?